Emma Teeling

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Emma Teeling

Emma Teeling for The Story of Your Stuff.jpg
Born
Clontarf, Dublin, Ireland
NationalityIrish
Education Holy Faith Secondary School, Clontarf
Alma mater University College Dublin (BSc), University of Edinburgh (MSc), Queen's University Belfast (with University of California at Riverside) (PhD)
Known forStudies of chiroptera (bats), including genome and longevity, and the possible application to human ageing and certain conditions
Spouse Peter T. Gallagher
Children2
Awards Science Foundation Ireland (SFI) President of Ireland Award (2006), European Research Council Starting Investigator (2013-2018), Chevalier in the Ordre des Palmes académiques
Scientific career
Fields Zoology, Genetics (Phylogenetics, Genomics)
Institutions University College Dublin (2005-), National Cancer Institute (2002-2005)
Thesis A molecular perspective on chiropteran systematics (2001)

Emma Caroline Teeling [1] MRIA is an Irish zoologist, geneticist and genomicist, who specialises in the phylogenetics and genomics of bats. Her work includes understanding of the bat genome and study of how insights from other mammals such as bats might contribute to better understanding and management of ageing and a number of conditions, including deafness and blindness, in humans. She is the co-founder of the Bat1K project to map the genomes of all species of bat. She is also concerned with understanding of the places of bats in the environment and how to conserve their ecosystem.

Contents

Teeling is a full professor at University College Dublin, where she has founded two scientific centres: the Laboratory of Molecular Evolution and Mammalian Phylogenetics (also known as the "BatLab"), and the Dublin part of the Centre for Irish Bat Research. [2] Teeling is widely cited in her areas of study and is an elected member of Ireland's national academy, the Royal Irish Academy. [3]

Early life

Emma Teeling was born to John and Deirdre Teeling. Her father is an academic, and serial entrepreneur in the mining, Irish whiskey and other sectors, while her mother is an academic in the area of education; they married in 1971. She has two younger brothers, Jack and Stephen, and she and her siblings grew up in Clontarf, where her father has his head office for multiple companies, [4] and with her mother working in a school in nearby Coolock, [5] another northern suburb of Dublin. [6] She played Dublin-level camogie for Fairview. [7] She attended Holy Faith Secondary School, Clontarf, [8] and was the author of one of a set of short articles about late 1980s Moscow for a Soviet Supplement in the Irish Independent, after a school trip to the USSR. [9]

Higher education

From 1991 to 1995, Teeling took a B.Sc. in Zoology at University College Dublin (UCD), which included study of deer in Dublin's Phoenix Park. [8] She further studied at the University of Edinburgh, for an M.Sc. in Animal Behaviour and Welfare, from 1995, including working with swift foxes [8] at the Cochrane Ecological Institute in Canada. [10] She then saw an advertisement for PhD studies relating to bats, [8] and pursued this from 1997 at Queen's University, Belfast and the University of California at Riverside. [11] She filed her thesis on A molecular perspective on chiropteran systematics in December 2001, and received her PhD in molecular phylogenetics from Queen's. [1]

Career

Teeling worked as a postdoctoral research fellow from 2002 to 2004 at the US National Cancer Institute. In 2005, she returned to Ireland to take a role as lecturer in Evolution and Genetics in the School of Biology and Environmental Science at UCD, securing tenure in 2006. She founded the Laboratory of Molecular Evolution and Mammalian Phylogenetics (known as the "BatLab" even in official materials) [12] [13] at UCD in 2005, and the Centre for Irish Bat Research at UCD in 2008; she remains one of the four Principal Investigators of this cross-border project, and its director. [14] The Laboratory of Molecular Evolution and Mammalian Phylogenetics conducts a large amount of field work in Brittany, working with a conservation organisation, Bretagne Vivante. [15] Teeling is also concerned with understanding of bat populations and their broader ecosystems, and bat conservation. [2]

Teeling was promoted to associate professor (in Evolution and Genetics) in 2012, [2] and later to full professor. She is also Head of Zoology. [10] In addition to her research work, she teaches or coordinates a number of courses, and supervises PhD studies. [16] As of 2020, she is also Deputy Director of UCD's Earth Institute. [17]

Research and funding

Over the first 15 years since doctoral qualification, Teeling secured more than 4.4 million euro in research funding for her projects and laboratories. [2] She was one of three applicants selected for a Science Foundation Ireland (SFI) President of Ireland Award in 2006, [18] providing committed funding of over 1.2 million euro over its duration from October 2006 to March 2012 for comparative genomic studies in mammals. [19] She also secured Science Foundation Ireland funding of over 200,000 euro for a study of the population dynamics and conservation status of a small bat, and a small grant for work around ecology and evolution with reference to bats. [19]

Teeling secured an award from the European Research Council, for a Starting Investigator work (2013-2018), [2] supported by further SFI commitments. [20] This resulted in the Ageless project, considering how bats weighing as little as 7g can live for over 40 years, possibly due to optimised telomere management. [21] Noting that the Myotis genus of bats don't appear to die from old age as such, Teeling commented "Studying wild bats in an ageing context may provide exciting new solutions to slow down the ageing process and ultimately extend human health-spans." [22]

Teeling co-founded the Bat1K project to sequence the genomes of all living bat species. [23] [24] A report from this project, looking at the genomes of six bat species and mentioning Teeling and a colleague, was featured on the front cover of Nature magazine in 2020; [25] this recognition was highlighted by the official University College Dublin Facebook page as "Congratulations to UCD's resident Batlady Prof Emma Teeling on making the cover of this month's @Nature with her newest genomic research." [26]

Recognition

Teeling was elected to the highest academic honour in Ireland, membership of the national academy, the Royal Irish Academy, in 2016. [3] In 2017, For her scientific work, she was awarded the rank of Chevalier in the Ordre des Palmes académiques; this award, known as "the purple", is the oldest civilian decoration in France, established by Napoleon. [27] Her husband was also made a Chevalier at the time, for his work in astrophysics. [27]

Teeling attended the World Economic Forum (WEF) conference in Davos, Switzerland in 2020 as a top level academic/think tank advisor. [28] She was invited to present her work on ageing at the Forum, [29] where she delivered a presentation entitled Bats and the Secret of Everlasting Youth in a closed session in January 2020. [30]

After Davos, in late February 2020, Prof Teeling was invited as one of the speakers at the week-long Genomics Winter School within the Future Biotech Winter Retreat in Novosibirsk, Siberia, Russia, [31] and to the leading genetic and cytological research facility of the Russian Federation, where she presented, and performed a "Q&A" session, on bats and longevity. [32]

Publication

Teeling has written and co-written many articles, papers and chapters, some of which are widely cited. Extant are more than 100 documents, with a citation level, per Scopus, of 6424 applications across 4751 citing documents, and a h-index of 31 ("very good"). [33] [2] Papers which Teeling has authored or to which she has contributed include: [2]

while chapters contributed include: [2]

Governance and voluntary roles

Teeling is a member of the Society for Molecular Biology and Evolution and was a member of the society's 2012 Annual Meeting Committee, which managed the event in Dublin, Ireland [48] and later a member of the society's governing council. [49] She is also on the editorial board of one of the society's two journals, the Journal of Molecular Biology and Evolution. [50]

She is also a member of the editorial board of Oxford University Press's open-access journal Giga Science. [51]

Teeling was appointed to the board of the Irish Research Council. [52] She was elected as one of the professorial members of the Governing Authority of UCD in 2019, for a five-year term. [53]

Teeling has presented a TEDx talk, on the genome of bats, which has been viewed, as of 16 June 2022, more than 565,000 times. [54] University College Dublin has also uploaded one of her lectures, 'Bats: secrets of extended lifespan', to YouTube. [55] She has been interviewed and featured on radio - on one occasion in episode 2 of a series, 'Bright Sparks', which also interviewed her astronomer husband, in episode 8, about his work - [56] [57] [58] and television. On one occasion programme-makers accompanied her team when it was locating bats in old churches in Brittany. [59] Following the release of the first six bat genomes by the Bat1K consortium, Teeling was interviewed by the BBC and commented on how bats' unique immune systems may help them defend against viruses, including COVID. [60]

Personal life

Teeling is married to astrophysicist Peter Gallagher, a senior professor at the Dublin Institute for Advanced Studies and adjunct professor at Trinity College Dublin, at the latter of which he worked for many years. They both came from Clontarf in Dublin but only met in first year Science in UCD. They lived near Washington D.C. for part of their time in the US during advanced studies, before moving back to Ireland together when Teeling received a job offer from UCD. [61] They have two sons. [27] [62] Teeling invested in the first round of funding for her brothers' whiskey distillery company, the Teeling Whiskey Company, operating the Teeling Distillery, the first new distillery in Dublin for 125 years. [63] [64]

Related Research Articles

<span class="mw-page-title-main">Animal echolocation</span> Method used by several animal species to determine location using sound

Echolocation, also called bio sonar, is a biological active sonar used by several animal groups, both in the air and underwater. Echolocating animals emit calls and listen to the echoes of those calls that return from various objects near them. They use these echoes to locate and identify the objects. Echolocation is used for navigation, foraging, and hunting prey.

<span class="mw-page-title-main">Microbat</span> Suborder of mammals

Microbats constitute the suborder Microchiroptera within the order Chiroptera (bats). Bats have long been differentiated into Megachiroptera (megabats) and Microchiroptera, based on their size, the use of echolocation by the Microchiroptera and other features; molecular evidence suggests a somewhat different subdivision, as the microbats have been shown to be a paraphyletic group.

<span class="mw-page-title-main">Megabat</span> Family of fruit bats

Megabats constitute the family Pteropodidae of the order Chiroptera (bats). They are also called fruit bats, Old World fruit bats, or—especially the genera Acerodon and Pteropus—flying foxes. They are the only member of the superfamily Pteropodoidea, which is one of two superfamilies in the suborder Yinpterochiroptera. Internal divisions of Pteropodidae have varied since subfamilies were first proposed in 1917. From three subfamilies in the 1917 classification, six are now recognized, along with various tribes. As of 2018, 197 species of megabat had been described.

<span class="mw-page-title-main">Vespertilionidae</span> Family of microbats

Vespertilionidae is a family of microbats, of the order Chiroptera, flying, insect-eating mammals variously described as the common, vesper, or simple nosed bats. The vespertilionid family is the most diverse and widely distributed of bat families, specialised in many forms to occupy a range of habitats and ecological circumstances, and it is frequently observed or the subject of research. The facial features of the species are often simple, as they mainly rely on vocally emitted echolocation. The tails of the species are enclosed by the lower flight membranes between the legs. Over 300 species are distributed all over the world, on every continent except Antarctica. It owes its name to the genus Vespertilio, which takes its name from a word for bat, vespertilio, derived from the Latin term vesper meaning 'evening'; they are termed "evening bats" and were once referred to as "evening birds".

<span class="mw-page-title-main">Horseshoe bat</span> Family of mammals

Horseshoe bats are bats in the family Rhinolophidae. In addition to the single living genus, Rhinolophus, which has about 106 species, the extinct genus Palaeonycteris has been recognized. Horseshoe bats are closely related to the Old World leaf-nosed bats, family Hipposideridae, which have sometimes been included in Rhinolophidae. The horseshoe bats are divided into six subgenera and many species groups. The most recent common ancestor of all horseshoe bats lived 34–40 million years ago, though it is unclear where the geographic roots of the family are, and attempts to determine its biogeography have been indecisive. Their taxonomy is complex, as genetic evidence shows the likely existence of many cryptic species, as well as species recognized as distinct that may have little genetic divergence from previously recognized taxa. They are found in the Old World, mostly in tropical or subtropical areas, including Africa, Asia, Europe, and Oceania.

<span class="mw-page-title-main">Euarchontoglires</span> Superorder of mice, humans, their most recent common ancestor, and all its descendants

Euarchontoglires is a clade and a superorder of mammals, the living members of which belong to one of the five following groups: rodents, lagomorphs, treeshrews, primates, and colugos.

<span class="mw-page-title-main">Laurasiatheria</span> Clade of mammals

Laurasiatheria is a superorder of placental mammals that groups together true insectivores (eulipotyphlans), bats (chiropterans), carnivorans, pangolins (pholidotes), even-toed ungulates (artiodactyls), odd-toed ungulates (perissodactyls), and all their extinct relatives. From systematics and phylogenetic perspectives, it is subdivided into order Eulipotyphla and clade Scrotifera. It is a sister group to Euarchontoglires with which it forms the magnorder Boreoeutheria. Laurasiatheria was discovered on the basis of the similar gene sequences shared by the mammals belonging to it; no anatomical features have yet been found that unite the group, although a few have been suggested such as a small coracoid process, a simplified hindgut and allantoic vessels that are large to moderate in size. The Laurasiatheria clade is based on DNA sequence analyses and retrotransposon presence/absence data. The superorder originated on the northern supercontinent of Laurasia, after it split from Gondwana when Pangaea broke up. Its last common ancestor is supposed to have lived between ca. 76 to 90 million years ago.

<span class="mw-page-title-main">Boreoeutheria</span> Magnorder of mammals containing Laurasiatheria and Euarchontoglires

Boreoeutheria is a magnorder of placental mammals that groups together superorders Euarchontoglires and Laurasiatheria. With a few exceptions male animals in the clade have a scrotum, an ancestral feature of the clade. The sub-clade Scrotifera was named after this feature.

<span class="mw-page-title-main">Pegasoferae</span> Group of mammals comprising horses, bats, carnivores, and pangolins, among others

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<i>Nyctophilus geoffroyi</i> Species of bat

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In evolutionary biology, the flying primate hypothesis is that megabats, a subgroup of Chiroptera, form an evolutionary sister group of primates. The hypothesis began with Carl Linnaeus in 1758, and was again advanced by J.D. Smith in 1980. It was proposed in its modern form by Australian neuroscientist Jack Pettigrew in 1986 after he discovered that the connections between the retina and the superior colliculus in the megabat Pteropus were organized in the same way found in primates, and purportedly different from all other mammals. This was followed up by a longer study published in 1989, in which this was supported by the analysis of many other brain and body characteristics. Pettigrew suggested that flying foxes, colugos, and primates were all descendants of the same group of early arboreal mammals. The megabat flight and the colugo gliding could be both seen as locomotory adaptations to a life high above the ground.

<span class="mw-page-title-main">Yinpterochiroptera</span> Suborder of bats

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<span class="mw-page-title-main">Yangochiroptera</span> Suborder of bats

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<span class="mw-page-title-main">Bat</span> Order of flying mammals

Bats are flying mammals of the order Chiroptera. With their forelimbs adapted as wings, they are the only mammals capable of true and sustained flight. Bats are more agile in flight than most birds, flying with their very long spread-out digits covered with a thin membrane or patagium. The smallest bat, and arguably the smallest extant mammal, is Kitti's hog-nosed bat, which is 29–34 millimetres in length, 150 mm (6 in) across the wings and 2–2.6 g in mass. The largest bats are the flying foxes, with the giant golden-crowned flying fox reaching a weight of 1.6 kg and having a wingspan of 1.7 m.

<span class="mw-page-title-main">Bat flight</span>

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<span class="mw-page-title-main">Kenneth H. Wolfe</span> Irish geneticist and academic

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<span class="mw-page-title-main">Aoife McLysaght</span> Irish geneticist and professor

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<span class="mw-page-title-main">Rhinolophoidea</span> Superfamily of bats

Rhinolophoidea is a superfamily of bats. It contains the following families: Craseonycteridae, Hipposideridae, Megadermatidae, Rhinolophidae, Rhinonycteridae, and Rhinopomatidae. It is one of two superfamilies that comprise the suborder Yinpterochiroptera, the other being Pteropodoidea, which only contains the family Pteropodidae.

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References

  1. 1 2 "Catalogue record: A molecular perspective on chiropteran systematics". Queen's University Belfast - Library - Catalogie. Retrieved 12 September 2020.
  2. 1 2 3 4 5 6 7 8 "Emma Teeling". School of Biology and Environmental Science, UCD. University College Dublin (UCD). Retrieved 12 September 2020.
  3. 1 2 "Member Directory - T". Royal Irish Academy. Retrieved 13 September 2020. Emma Teeling, Science 2016
  4. Lynch, Donal (24 May 2014). "Ireland's top whiskey magnate is looking for diamonds in the rough". Irish Independent. Retrieved 13 September 2020. ... met at a party ... married in 1971 ... three children ... Seafield Road, Clontarf ...
  5. Mercy College Coolock Newsletter Summer 2011. Dublin, Ireland: Mercy College Coolock. 2011. pp. 2–4. "Mercy College... 32 years... started in 1979 as a newly qualified Guidance Counsellor
  6. Daly, Linda (4 February 2012). "Fame and fortune: John Teeling". The Times. Retrieved 13 September 2020.
  7. (staff writer) (26 May 1983). "Primary Camogie champs!". Evening Herald. (a), (b) and Emma Teeling turned in very good displays for Fairview...
  8. 1 2 3 4 "Career Stories: Emma Teeling, head of UCD Bat Lab". Zoology at RSSING. 16 December 2013. Retrieved 21 September 2020. In secondary school, at the Holy Faith Convent in Clontarf, Dublin, she discovered she was good at science.
  9. Teeling, Emma (15 November 1989). "The Third Degree (within From Russia with Love...)". Irish Independent. No. Soviet Supplement. Dublin, Ireland. pp. 12–13.
  10. 1 2 "Professor Emma Teeling". University College Dublin (UCD). Retrieved 12 September 2020. Full Professor / School of Biology and Environmental Science
  11. "Emma Teeling: Lecturer, Scientist, Zoologist". Keynotes.org. Retrieved 12 September 2020. Dubbed as Ireland's Batwoman, Dr. Emma Teeling's speeches revolve around how different organisms can help improve science and medicine. ... Ph.D. in Molecular Phylogenetics at Queen's University Belfast, Northern Ireland and at University of California Riverside, USA
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  18. "TCD researcher receives President of Ireland Young Researcher Awards 2007". Trinity News and Events. Trinity College Dublin. Retrieved 12 September 2020. The other two PIYRA award winners are Dr Emma Teeling, UCD and Dr Oliver Blacque, UCD.
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  22. Kwon, Diana (7 February 2018). "Study: Telomeres Don't Shorten with Age in Longest-Lived Bats". theScientist.com. Retrieved 21 September 2020.
  23. Teeling, Emma C.; Vernes, Sonja C.; Dávalos, Liliana M.; Ray, David A.; Gilbert, M. Thomas P.; Myers, Eugene (2018). "Bat Biology, Genomes, and the Bat1K Project: To Generate Chromosome-Level Genomes for All Living Bat Species". Annual Review of Animal Biosciences. 6: 23–46. doi: 10.1146/annurev-animal-022516-022811 . PMID   29166127.
  24. "The Bat1K genome sequencing initiative". Inside Ecology. 9 May 2018. Retrieved 20 September 2020. Prof. Teeling is the co-founder and Director of the Bat1K genome sequencing initiative.
  25. "Secrets of the bat clade". Nature. 583 (7817). 23 July 2020. Retrieved 20 September 2020. In this week's issue, Emma Teeling, Sonja Vernes and their colleagues present reference-quality genomes for six species of bat sequenced by the Bat1K consortium.
  26. "Congratulations to UCD's resident Batlady Prof Emma Teeling on making the cover of this month's @Nature with her newest genomic research". University College Dublin on Facebook. University College Dublin. 28 July 2020. Retrieved 25 September 2020. Congratulations to UCD's resident Batlady Prof Emma Teeling on making the cover of this month's Nature with her newest genomic research . . . The breakthrough offers fresh clues into the animals 'exceptional immunity', which protects them against cancer and other deadly diseases including the coronavirus.
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  29. Brennan, Joe (22 January 2020). "Davos Diary: UCD prof goes batty, Ivanka hits town and Prince Charles takes the stage / Emma Teeling believes bats hold the key to slowing down the ageing process". Irish Times. Retrieved 21 September 2020. Emma Teeling, a bat expert and newbie to ... the World Economic Forum (WEF) conference in Davos ... greatest hope to solving ... second-biggest issue, ... how to slow down the ageing process in humans.
  30. "Emma Teeling, Professor, School of Biology and Environmental Science, University College Dublin, Ireland, speaking in the Bats and the Secret of Everlasting Youth session at the World Economic Forum". World Economic Forum Annual Meeting. Davos-Klosters, Switzerland: World Economic Forum. 22 January 2020. Retrieved 22 September 2020.
  31. "Winter School "Future Biotech Winter Retreat 2020"". Future Biotech Programme. Retrieved 18 October 2020. ... current developments in genomics of the major branches of life: viruses, microorganisms, plants, and animals including humans. ... 22 to 27 of February 2020 in Akademgorodok, Novosibirsk ... Emma Teeling School of Biology and Environmental Science, University College Dublin
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  34. Teeling, E. C. (28 January 2005). "A Molecular Phylogeny for Bats Illuminates Biogeography and the Fossil Record". Science. 307 (5709): 580–584. Bibcode:2005Sci...307..580T. doi:10.1126/science.1105113. PMID   15681385. S2CID   25912333.
  35. Huang, Zixia; Foley, Nicole M.; Jebb, David; Petit, Eric J.; Puechmaille, Sébastien J.; Teeling, Emma C.; Touzalin, Frédéric; Whelan, Conor V. (July 2019). "Longitudinal comparative transcriptomics reveals unique mechanisms underlying extended healthspan in bats". Nature Ecology & Evolution. 3 (7): 1110–1120. doi: 10.1038/s41559-019-0913-3 . PMID   31182815.
  36. Jones, Gareth; Teeling, Emma C. (March 2006). "The evolution of echolocation in bats". Trends in Ecology & Evolution. 21 (3): 149–156. doi:10.1016/j.tree.2006.01.001. PMID   16701491.
  37. Teeling, Emma C. (July 2009). "Hear, hear: the convergent evolution of echolocation in bats?". Trends in Ecology & Evolution. 24 (7): 351–354. doi:10.1016/j.tree.2009.02.012. PMID   19482373.
  38. McMahon, Barry J.; Teeling, Emma C.; Höglund, Jacob (November 2014). "How and why should we implement genomics into conservation?". Evolutionary Applications. 7 (9): 999–1007. doi: 10.1111/eva.12193 . PMC   4231591 . PMID   25553063.
  39. Foley, Nicole M.; Springer, Mark S.; Teeling, Emma C. (19 July 2016). "Mammal madness: is the mammal tree of life not yet resolved?". Philosophical Transactions of the Royal Society B: Biological Sciences. 371 (1699). doi: 10.1098/rstb.2015.0140 . PMC   4920340 . PMID   27325836.
  40. Springer, M. S.; Teeling, E. C.; Madsen, O.; Stanhope, M. J.; de Jong, W. W. (22 May 2001). "Integrated fossil and molecular data reconstruct bat echolocation". Proceedings of the National Academy of Sciences. 98 (11): 6241–6246. Bibcode:2001PNAS...98.6241S. doi: 10.1073/pnas.111551998 . PMC   33452 . PMID   11353869.
  41. Davies, K T J; Cotton, J A; Kirwan, J D; Teeling, E C; Rossiter, S J (May 2012). "Parallel signatures of sequence evolution among hearing genes in echolocating mammals: an emerging model of genetic convergence". Heredity. 108 (5): 480–489. doi:10.1038/hdy.2011.119. PMC   3330687 . PMID   22167055.
  42. Springer, Mark S.; Burk-Herrick, Angela; Meredith, Robert; Eizirik, Eduardo; Teeling, Emma; O'Brien, Stephen J.; Murphy, William J. (1 August 2007). "The Adequacy of Morphology for Reconstructing the Early History of Placental Mammals". Systematic Biology. 56 (4): 673–684. doi:10.1080/10635150701491149. PMID   17661234.
  43. Zhao, Huabin; Rossiter, Stephen J.; Teeling, Emma C.; Cotton, James A.; Li, Chanjuan; Zhang, Shuyi (2 June 2009). "The evolution of color vision in nocturnal mammals". Proceedings of the National Academy of Sciences. 106 (22): 8980–8985. Bibcode:2009PNAS..106.8980Z. doi: 10.1073/pnas.0813201106 . PMC   2690009 . PMID   19470491.
  44. Hayden, S.; Bekaert, M.; Crider, T. A.; Mariani, S.; Murphy, W. J.; Teeling, E. C. (1 January 2010). "Ecological adaptation determines functional mammalian olfactory subgenomes". Genome Research. 20 (1): 1–9. doi: 10.1101/gr.099416.109 . PMC   2798820 . PMID   19952139.
  45. Teeling, E. C.; Madsen, O.; Van Den Bussche, R. A.; de Jong, W. W.; Stanhope, M. J.; Springer, M. S. (5 February 2002). "Microbat paraphyly and the convergent evolution of a key innovation in Old World rhinolophoid microbats". Proceedings of the National Academy of Sciences of the United States of America. 99 (3): 1431–1436. Bibcode:2002PNAS...99.1431T. doi: 10.1073/pnas.022477199 . PMC   122208 . PMID   11805285.
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