Aoife McLysaght

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Aoife McLysaght
Aoife McLysaght.jpg
Alma mater Trinity College Dublin (BA, PhD)
Awards
Scientific career
Fields
Institutions Trinity College Dublin
University of California, Irvine
Thesis Evolution of vertebrate genome organisation  (2002)
Doctoral advisor Kenneth H. Wolfe [2]
Website www.gen.tcd.ie/molevol

Aoife McLysaght is an Irish geneticist and a professor in the Molecular Evolution Laboratory of the Smurfit Institute of Genetics, Trinity College Dublin, [1] [3] [4] [5] and Government Science Advisor for the Republic of Ireland. [6]

Contents

Education

McLysaght was educated at the Trinity College Dublin where she was awarded a Bachelor of Arts degree in Genetics in 1998, followed by a PhD in 2002 for research supervised by Kenneth H. Wolfe on the evolution of vertebrate genome organisation. [2] [7] [8] [9]

Career and research

Following her PhD, she completed postdoctoral research at the University of California, Irvine [10] working with Brandon Gaut before returning to work in Dublin in 2003. Her research in molecular evolution and comparative genomics [1] has been published in leading peer-reviewed scientific journals including Nature , [11] Nature Genetics , [12] Bioinformatics , [13] Genome Research , [14] PNAS [15] [16] and the journal Yeast . [17]

She has served as senior editor and associate editor for the journals Molecular Biology and Evolution and Genome Biology and Evolution , and is on the editorial board of the journal Cell Reports . She is a member of the Society for Molecular Biology and Evolution (SMBE) and The Genetics Society.[ citation needed ] She served as Treasurer of SMBE 2012–14 and was elected President of the Society in 2017. [18]

She was appointed Government Science Advisor for the Republic of Ireland in October 2024. [6]

Outreach and media

McLysaght is a regular contributor to public events, and has spoken at IGNITE Electric Picnic, [19] [20] TEDx, The Royal Institution, and on the BBC Radio 4 programme The Infinite Monkey Cage . [21] She brought genetics to a wider audience in the Royal Institution 2013 advent calendar [10] where she featured in videos on human chromosome 1, [22] human chromosome 14, [23] mitochondrial DNA (mtDNA) [24] and the Science Gallery, Dublin. In 2018 she joined with Alice Roberts to write and present the televised Royal Institution Christmas Lectures. [25]

Awards and honours

McLysaght was awarded European Research Council (ERC) Consolidator Grant 2018–23 and an ERC Starting Researcher grant from 2013 to 2018, and the President of Ireland Young Researcher's Award by Science Foundation Ireland (SFI) in 2005. [26] [27] She gave the J. B. S. Haldane lecture of The Genetics Society in 2016. [28] She was one of eight women scientists whose portrait was commissioned as part of the Royal Irish Academy's Women on Walls project. [29] In March 2025, with Jocelyn Bell Burnell, she featured on an Irish postage stamp recognising Women in STEM. [30]

In 2010 she was elected a fellow of Trinity College Dublin. [31]

Personal life

McLysaght is a granddaughter of genealogist Edward MacLysaght. [32] McLysaght has two children, and a dog whose genome has been sequenced. [33]

References

  1. 1 2 3 4 Aoife McLysaght publications indexed by Google Scholar OOjs UI icon edit-ltr-progressive.svg
  2. 1 2 McLysaght, Aoife (2002). Evolution of vertebrate genome organisation (PDF) (PhD thesis). Trinity College Dublin. OCLC   842498402. Archived from the original (PDF) on 6 November 2017.
  3. ↑ Aoife McLysaght publications indexed by the Scopus bibliographic database. (subscription required)
  4. ↑ Aoife McLysaght at DBLP Bibliography Server OOjs UI icon edit-ltr-progressive.svg
  5. ↑ Aoife McLysaght publications from Europe PubMed Central OOjs UI icon edit-ltr-progressive.svg
  6. 1 2 "Geneticist Aoife McLysaght appointed Government science adviser". Royal Irish Academy. 8 October 2024. Retrieved 26 February 2025.
  7. ↑ Aoife McLysaght's ORCID   0000-0003-2552-6220
  8. ↑ Wolfe, Ken (2017). "Wolfe lab alumni". wolfe.ucd.ie. Archived from the original on 11 July 2017.
  9. ↑ "Aoife McLysaght Academic Tree". academictree.org.
  10. 1 2 O’Connell, Claire (2014). "Professor brings science to life with flair". siliconrepublic.com.
  11. ↑ Lander, Eric S.; Linton, Lauren M.; Birren, Bruce; Nusbaum, Chad; Zody, Michael C.; Baldwin, Jennifer; Devon, Keri; Dewar, Ken; Doyle, Michael; FitzHugh, William; Funke, Roel; et al. (2001). "Initial sequencing and analysis of the human genome". Nature. 409 (6822): 860–921. doi: 10.1038/35057062 . hdl: 2027.42/62798 . ISSN   0028-0836. PMID   11237011. Lock-green.svg
  12. ↑ McLysaght, Aoife; Hokamp, Karsten; Wolfe, Kenneth H. (2002). "Extensive genomic duplication during early chordate evolution". Nature Genetics. 31 (2): 200–204. doi:10.1038/ng884. ISSN   1061-4036. PMID   12032567. S2CID   8263376. Closed Access logo transparent.svg
  13. ↑ Pollastri, G.; McLysaght, A. (2004). "Porter: a new, accurate server for protein secondary structure prediction" (PDF). Bioinformatics. 21 (8): 1719–1720. doi: 10.1093/bioinformatics/bti203 . ISSN   1367-4803. PMID   15585524.
  14. ↑ Knowles, D. G.; McLysaght, A. (2009). "Recent de novo origin of human protein-coding genes". Genome Research. 19 (10): 1752–1759. doi:10.1101/gr.095026.109. ISSN   1088-9051. PMC   2765279 . PMID   19726446.
  15. ↑ McLysaght, A.; Baldi, P. F.; Gaut, B. S. (2003). "Extensive gene gain associated with adaptive evolution of poxviruses". Proceedings of the National Academy of Sciences. 100 (26): 15655–15660. doi: 10.1073/pnas.2136653100 . ISSN   0027-8424. PMC   307623 . PMID   14660798.
  16. ↑ Makino, T.; McLysaght, A. (2010). "Ohnologs in the human genome are dosage balanced and frequently associated with disease". Proceedings of the National Academy of Sciences. 107 (20): 9270–9274. doi: 10.1073/pnas.0914697107 . ISSN   0027-8424. PMC   2889102 . PMID   20439718.
  17. ↑ McLysaght, Aoife; Enright, Anton J.; Skrabanek, Lucy; Wolfe, Kenneth H. (2000). "Estimation of Synteny Conservation and Genome Compaction Between Pufferfish (Fugu) and Human". Yeast. 1 (1): 22–36. doi:10.1002/(SICI)1097-0061(200004)17:1<22::AID-YEA5>3.0.CO;2-S. ISSN   0749-503X. PMC   2447035 . PMID   10797599.
  18. ↑ "SMBE Council". smbe.org. Society for Molecular Biology & Evolution. 2019. Retrieved 21 January 2019.
  19. ↑ "Aoife McLysaght at IGNITE Dublin #1". youtube.com. YouTube.
  20. ↑ "Aoife McLysaght at IGNITE at Electric Picnic". youtube.com. YouTube.
  21. ↑ "Alfred Russel Wallace: The Infinite Monkey Cage, Series 8 Episode 5 of 6". bbc.co.uk. BBC.
  22. ↑ "Chromosome 1 – The Stuff of Life". youtube.com. YouTube.
  23. ↑ "Chromosome 14 – Immunoglobulins: building our immune system". youtube.com. YouTube.
  24. ↑ "Chromosome 24 – mtDNA, Lynn Margulis and the mitochondrial DNA". youtube.com. YouTube.
  25. ↑ "CHRISTMAS LECTURES 2018: Who am I?". rigb.org. Royal Institution. Archived from the original on 23 October 2019. Retrieved 27 December 2018.
  26. ↑ "Professor Aoife Mclysaght". accenture.com. Accenture.
  27. ↑ "Trinity Research: Professor Aoife McLysaght". tcd.ie.
  28. ↑ "JBS Haldane Lecture – Genetics Society". genetics.org.uk.
  29. ↑ "Women on Walls". www.ria.ie. Royal Irish Academy. 2016. Retrieved 26 December 2020.
  30. ↑ Cunningham, Paul (5 March 2025). "Special stamps launched to celebrate women in STEM". Raidió Teilifís Éireann.
  31. ↑ "Trinity Monday 2010 - Fellows and Scholars". www.tcd.ie. Trinity College Dublin. 12 April 2010. Retrieved 1 July 2023.
  32. ↑ McLysaght, Aoife (2014). "The genetic imprint of Niall of the Nine Hostages". irishtimes.com. The Irish Times.
  33. ↑ "Cara Genome Project (@CaraGenome) | Twitter". twitter.com.
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