Erin K. O'Shea

Last updated
Erin K. O'Shea
Erin O'Shea, Howard Hughes Medical Institute (HHMI).jpg
Education Smith College (BS)
Massachusetts Institute of Technology (MS, PhD)
Awards NAS Award in Molecular Biology (2001)
Scientific career
Fields Biochemistry
Institutions Harvard University
Howard Hughes Medical Institute
Doctoral advisor Peter S. Kim
Other academic advisors Robert Tjian
Ira Herskowitz

Erin K. O'Shea is an American biologist who is president of the Howard Hughes Medical Institute (HHMI). In 2013, she was named HHMI's vice president and chief scientific officer. Prior to that, she was a professor of molecular and cellular biology and chemistry and chemical biology at Harvard University. In 2016, her appointment as future, and first woman, president of HHMI was announced. [1] She has been a Howard Hughes Medical Institute (HHMI) investigator since 2000. [2]

Contents

Early life and education

Erin O'Shea is one of five children, born in Leroy, New York. [3]

O'Shea earned her Bachelor of Arts in biochemistry from Smith College in 1988 and her PhD in chemistry from MIT in 1992 at age 26 [4] [3] working with Peter S. Kim studying leucine zippers. She was a postdoctoral fellow at University of California, Berkeley from 1992 to 1993. [4]

Career and research

During her postdoctoral fellowship, O'Shea worked with Robert Tjian and Ira Herskowitz studying chromatin regulation of transcription in yeast. [5] When she was joined by her graduate school colleague Jonathan Weissman, they began to determine the location and abundance of all of the proteins in the yeast genome. They ultimately made two libraries both with GFP-fused protein with tandem affinity purification (TAP)-tags. [6] [7]

After her PhD, O'Shea was briefly a Basic Research Fellow before joining the faculty of University of California, San Francisco as an assistant professor in 1993. [8]

In 2005, she was recruited to Harvard University to be the director of the (FAS) Center for Systems Biology and a professor of molecular and cellular biology and chemistry and chemical biology. Her research is focused on gene regulation and the biology of a three-protein circadian clock. In 2012, she was elected to be HHMI's new Vice President and Chief Scientific Officer leading the HHMI Investigator Program succeeding Jack Dixon. She will continue to maintain her lab at Harvard. [9] [10]

Awards and honors

O'Shea was a Packard Foundation Fellow in 1994, [11] and won young investigator awards from the American Society for Cell Biology in 2000, [12] and the Protein Society in 2001. [13] She was selected as an HHMI investigator in 2000. [14]

In 2001, O'Shea won the NAS Award in Molecular Biology for "contributions to our understanding of signal transduction, regulation of protein movement into and out of the nucleus, and how phosphorylation controls protein activity". [15]

O'Shea was elected to the National Academy of Sciences in 2004, [16] as well as the American Academy of Arts and Sciences. [17] She was elected a member of the American Philosophical Society in 2019.

Personal life

O'Shea is married to Douglas Jeffery. In 2007, she said that she runs and wakeboards, and a large motivation to move to Harvard was for the chance to teach undergrads. [18]

She trained her dog, Zambo, from when he was a puppy. Zambo became national champion and then world champion in 2011, at the Universal World Sieger Championship in Austria. [19]

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References

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  2. "Erin K. O'Shea, PhD | HHMI.org". HHMI.org. Retrieved 2016-02-14.
  3. 1 2 "UCSF Magazine: Erin O'Shea: She Has a Love for Cool Science". pub.ucsf.edu. Archived from the original on 2016-02-23. Retrieved 2016-02-15.
  4. 1 2 "American Chemical Society". dgr.rints.com. Retrieved 2016-02-15.
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  6. Weissman, Jonathan S.; O'Shea, Erin K. (1 January 2009). "2004 Irving Sigal Young Investigator Award". Protein Science. 13 (12): 3333–3335. doi:10.1110/ps.041134604. PMC   2287319 . PMID   15557272.
  7. Huh, WK; Falvo, JV; Gerke, LC; Carroll, AS; Howson, RW; Weissman, JS; O'Shea, EK (Oct 16, 2003). "Global analysis of protein localization in budding yeast". Nature. 425 (6959): 686–91. Bibcode:2003Natur.425..686H. doi:10.1038/nature02026. PMID   14562095. S2CID   669199.
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