Erin S. Baker | |
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Nationality | American |
Alma mater | Montana State University University of California, Santa Barbara |
Awards | American Society for Mass Spectrometry Biemann Medal (2022) International Mass Spectrometry Foundation Curt Brunnée Award (2022) |
Scientific career | |
Institutions | University of North Carolina at Chapel Hill |
Thesis | From solution to a solvent-free environment : probing the structures of noncovalently bound DNA and RNA complexes (2005) |
Doctoral advisor | Michael T. Bowers |
Erin Shammel Baker is an American bioanalytical chemist specializing in developing ion mobility-mass spectrometry hybrid instruments for biological and environmental applications. Baker is an expert in the research of perfluoroalkyl and polyfluoroalkyl substances analysis.
Baker grew up on a cattle ranch in Montana, US. [1] Her interests in chemistry stemmed from a determination to understand the arsenic and cyanide pollution from gold mines that affected animals on her family's ranch and local wildlife. [2] [3] She obtained a bachelor of science in chemistry, with a minor in mathematics from Montana State University in 2001, where she conducted research using ion mobility spectrometry in Eric Grimsrud's laboratory. [1] [4] [5] She continued with research in ion mobility spectrometry in graduate school, and received a PhD in chemistry under the direction of Michael T. Bowers from University of California, Santa Barbara in 2005. [4] [5]
After graduation, Baker did post-doctoral research in Richard D. Smiths' laboratory at Pacific Northwest National Laboratory (PNNL), and was later promoted to senior research scientist. [1] [5] In 2018, she began her academic career at North Carolina State University as associate professor, and moved to University of North Carolina at Chapel Hill in 2022. [6]
Baker's publication record has been described as "prolific"; [3] she has co-authored 110 publications by 2019. [7] The scope of Baker's research involves both developing high throughput ion mobility–mass spectrometry (IMS–MS) systems [8] [9] [10] [11] [12] and using these hybrid instruments to study biological and environmental systems. [13] [14] [15] [16] [17] She was one of five researchers from the PNNL Interactive Omics Group who worked on the Structures for lossless ion manipulations (SLIM). [18] The group received the R&D 100 Award for their effort on SLIM in 2017. [19] She was also part of the PNNL team who helped with the commercialization of the Agilent 6560 Ion Mobility Quadrupole Time-of-Flight (IM–QTOF) Liquid Chromatography–Mass Spectrometer system. [3] [20] [21] She is an expert in the research of perfluoroalkyl and polyfluoroalkyl substances (PFAS) analysis. [22] [23] [24] She is the director of the Core of Advanced Platform Technologies Used for Remediation and Exploration (CAPTURE), the analytical branch of the PFAS Superfund Research Centre. [25] [26] [27] She is named one of the "Worldwide Water Warriors" in 2017. [28]
Baker served as a member-at-large for education for the American Society for Mass Spectrometry from 2019 to 2020. [29] She serves on the editorial board of Journal of the American Society for Mass Spectrometry, [30] Journal of Proteome Research, [31] International Journal of Mass Spectrometry, [32] and Scientific Reports. [33]
Tandem mass spectrometry, also known as MS/MS or MS2, is a technique in instrumental analysis where two or more stages of analysis using one or more mass analyzer are performed with an additional reaction step in between these analyses to increase their abilities to analyse chemical samples. A common use of tandem MS is the analysis of biomolecules, such as proteins and peptides.
Ion mobility spectrometry (IMS) It is a method of conducting analytical research that separates and identifies ionized molecules present in the gas phase based on the mobility of the molecules in a carrier buffer gas. Even though it is used extensively for military or security objectives, such as detecting drugs and explosives, the technology also has many applications in laboratory analysis, including studying small and big biomolecules. IMS instruments are extremely sensitive stand-alone devices, but are often coupled with mass spectrometry, gas chromatography or high-performance liquid chromatography in order to achieve a multi-dimensional separation. They come in various sizes, ranging from a few millimeters to several meters depending on the specific application, and are capable of operating under a broad range of conditions. IMS instruments such as microscale high-field asymmetric-waveform ion mobility spectrometry can be palm-portable for use in a range of applications including volatile organic compound (VOC) monitoring, biological sample analysis, medical diagnosis and food quality monitoring. Systems operated at higher pressure are often accompanied by elevated temperature, while lower pressure systems (1–20 hPa) do not require heating.
Christie G. Enke is a United States academic chemist who made pioneering contributions to the field of analytical chemistry.
David E. Clemmer is an analytical chemist and the Distinguished Professor and Robert and Marjorie Mann Chair of Chemistry at Indiana University in Bloomington, Indiana, where he leads the Clemmer Group. Clemmer develops new scientific instruments for ion mobility mass spectrometry (IMS/MS), including the first instrument for nested ion-mobility time-of-flight mass spectrometry. He has received a number of awards, including the Biemann Medal in 2006 "for his pioneering contributions to the integration of ion mobility separations with a variety of mass spectrometry technologies."
Michael L. Gross is Professor of Chemistry, Medicine, and Immunology, at Washington University in St. Louis. He was formerly Professor of Chemistry at the University of Nebraska-Lincoln from 1968–1994. He is recognized for his contributions to the field of mass spectrometry and ion chemistry. He is credited with the discovery of distonic ions, chemical species containing a radical and an ionic site on different atoms of the same molecule.
Matrix-assisted laser desorption electrospray ionization (MALDESI) was first introduced in 2006 as a novel ambient ionization technique which combines the benefits of electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI). An infrared (IR) or ultraviolet (UV) laser can be utilized in MALDESI to resonantly excite an endogenous or exogenous matrix. The term 'matrix' refers to any molecule that is present in large excess and absorbs the energy of the laser, thus facilitating desorption of analyte molecules. The original MALDESI design was implemented using common organic matrices, similar to those used in MALDI, along with a UV laser. The current MALDESI source employs endogenous water or a thin layer of exogenously deposited ice as the energy-absorbing matrix where O-H symmetric and asymmetric stretching bonds are resonantly excited by a mid-IR laser.
Ion mobility spectrometry–mass spectrometry (IMS-MS) is an analytical chemistry method that separates gas phase ions based on their interaction with a collision gas and their masses. In the first step, the ions are separated according to their mobility through a buffer gas on a millisecond timescale using an ion mobility spectrometer. The separated ions are then introduced into a mass analyzer in a second step where their mass-to-charge ratios can be determined on a microsecond timescale. The effective separation of analytes achieved with this method makes it widely applicable in the analysis of complex samples such as in proteomics and metabolomics.
Richard Dale Smith is a chemist and a Battelle Fellow and chief scientist within the biological sciences division, as well as the director of proteomics research at the Pacific Northwest National Laboratory (PNNL). Smith is also director of the NIH Proteomics Research Resource for Integrative Biology, an adjunct faculty member in the chemistry departments at Washington State University and the University of Utah, and an affiliate faculty member at the University of Idaho and the Department of Molecular Microbiology & Immunology, Oregon Health & Science University. He is the author or co-author of approximately 1100 peer-reviewed publications and has been awarded 70 US patents.
Structures for lossless ion manipulations (SLIM) are a form of ion optics to which various radio frequency and dc electric potentials can be applied and used to enable a broad range of ion manipulations, such as separations based upon ion mobility spectrometry, reactions, and storage. SLIM was developed by Richard D. Smith and coworkers at Pacific Northwest National Laboratory (PNNL) and are generally fabricated from arrays of electrodes on evenly spaced planar surfaces. In 2017, Erin S. Baker, Sandilya Garimella, Yehia Ibrahim, Richard D. Smith and Ian Webb from the Interactive Omics Group of PNNL received the R&D 100 Award for the development of SLIM.
Jennifer S. Brodbelt is an American chemist known for her research using mass spectrometry to characterize organic compounds, especially biopolymers and proteins.
In mass spectrometry, an ion funnel is a device used to focus a beam of ions using a series of stacked ring electrodes with decreasing inner diameter. A combined radio frequency and fixed electrical potential is applied to the grids. In electrospray ionization-mass spectrometry (ESI-MS), ions are created at atmospheric pressure, but are analyzed at subsequently lower pressures. Ions can be lost while they are shuttled from areas of higher to lower pressure due to the transmission process caused by a phenomenon called joule expansion or “free-jet expansion.” These ion clouds expand outward, which limits the amount of ions that reach the detector, so fewer ions are analyzed. The ion funnel refocuses and transmits ions efficiently from those areas of high to low pressure.
Renã A. S. Robinson is an associate professor and the Dorothy J. Wingfield Phillips Chancellor's Faculty Fellow in the department of chemistry at the Vanderbilt University, where she is the principal investigator of the RASR Laboratory.
Kristina Håkansson is an analytical chemist known for her contribution in Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry for biomolecular identification and structural characterization. Currently, she holds the position of Professor of Chemistry at University of Michigan. Her research focuses on mass spectrometry, primarily identification and characterization of protein posttranslational modifications by complementary fragmentation techniques such as electron-capture dissociation (ECD)/negative ion ECD (niECD) and infrared multiphoton dissociation (IRMPD) at low (femtomole) levels.
Perdita Elizabeth Barran is a Professor of Mass Spectrometry at the University of Manchester. She is Director of the Michael Barber Centre for Collaborative Mass Spectrometry. She develops and applies ion-mobility spectrometry–mass spectrometry to the study of molecule structure and is searching for biomarkers for Parkinson's disease. She is Associate Dean for Research Facility Development at the University of Manchester. In 2020 and 2021 she was seconded to work for the Department of Health and Social Care as an advisor on the use case for mass spectrometry as a diagnostic method for diagnosis of COVID infection.
Martin F. Jarrold is a physical and analytical chemist known for contributions to ion-mobility spectrometry, heat capacity measurements of metal clusters, and charge detection mass spectrometry. Martin is the Robert & Marjorie Mann Chair in the Department of Chemistry at Indiana University.
Abu Bakarr Kanu is a Sierra Leonean analytical chemist who is a professor at Winston-Salem State University. His research considers separation-type instrumentation for the rapid analysis of chemical and biological compounds. Kanu is also involved with education and outreach programmes, and works to bring hands-on chemistry lessons to young people in Sierra Leone.
Ying Ge is a Chinese-American chemist who is a Professor of Cell and Regenerative Biology at the University of Wisconsin–Madison. Her research considers the molecular mechanisms that underpin cardiac disease. She has previously served on the board of directors of the American Society for Mass Spectrometry. In 2020 Ge was named on the Analytical Scientist Power List.
Julia Laskin is the William F. and Patty J. Miller Professor of Analytical Chemistry at Purdue University. Her research is focused on the fundamental understanding of ion-surface collisions, understanding of phenomena underlying chemical analysis of large molecules in complex heterogeneous environments, and the development of new instrumentation and methods in preparative and imaging mass spectrometry.
Barbara Seliger Larsen is a mass spectrometrist, with a career in instrumentations and applications of mass spectrometry in industry, and served on the board of the American Society for Mass Spectrometry for several terms.
Ljiljana Paša-Tolić is a Croatian research scientist who is a research fellow in Functional and Systems Biology at the Pacific Northwest National Laboratory. She is responsible for developing capability in mass spectrometry at the PNNL Environmental Molecular Sciences Laboratory. Her research looks to develop analytical techniques to modify protein abundance.
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