Keri Lynn Russell is an American actress. She played the title role in the drama series Felicity (1998–2002), which won her a Golden Globe Award, and later portrayed Elizabeth Jennings in the spy thriller series The Americans (2013–2018), which earned her nominations for several Primetime Emmy and Golden Globe Awards. For playing the lead role in the political drama series The Diplomat (2023), she received further Emmy and Golden Globe nominations.
Sanofi S.A. is a French multinational pharmaceutical and healthcare company headquartered in Paris, France. The corporation was established in 1973 and merged with Synthélabo in 1999 to form Sanofi-Synthélabo. In 2004, Sanofi-Synthélabo merged with Aventis and renamed to Sanofi-Aventis, which were each the product of several previous mergers. It changed its name back to Sanofi in May 2011. The company is a component of the Euro Stoxx 50 stock market index.
Glycogen storage disease type II, also called Pompe disease, and formerly known as GSD-IIa. It is an autosomal recessive metabolic disorder which damages muscle and nerve cells throughout the body. It is caused by an accumulation of glycogen in the lysosome due to deficiency of the lysosomal acid alpha-glucosidase enzyme. GSD-II and Danon disease are the only glycogen storage diseases with a defect in lysosomal metabolism, and Pompe disease was the first glycogen storage disease to be identified, in 1932 by the Dutch pathologist J. C. Pompe.
Joel David Moore is an American character actor and director. Born and raised in Portland, Oregon, Moore studied acting in college before relocating to Los Angeles to pursue a film career. His first major role was as Owen Dittman in the 2004 comedy Dodgeball: A True Underdog Story, followed by roles in the comedy Grandma's Boy (2006), Terry Zwigoff's Art School Confidential (2006), and the independent slasher film Hatchet (2006).
Oregon Health & Science University (OHSU) is a public research university focusing primarily on health sciences with a main campus, including two hospitals, in Portland, Oregon. The institution was founded in 1887 as the University of Oregon Medical Department and later became the University of Oregon Medical School. In 1974, the campus became an independent, self-governed institution called the University of Oregon Health Sciences Center, combining state dentistry, medicine, nursing, and public health programs into a single center. It was renamed Oregon Health Sciences University in 1981 and took its current name in 2001, as part of a merger with the Oregon Graduate Institute (OGI), in Hillsboro. The university has several partnership programs including a joint PharmD Pharmacy program with Oregon State University in Corvallis.
The Shriners Children's Portland is a 29-bed, non-profit pediatric hospital located in Portland, in the U.S. state of Oregon. It specializes in orthopedics, cleft lip, and palate disorders as part of the 22-hospital system belonging to the Shriners Hospitals for Children. Established in 1924, the current campus opened in 1983. The hospital is located on the Oregon Health and Science University campus, and is active in the research and development of new technology.
Man's Best Friend is a 1993 American science fiction horror film, directed and written by John Lafia. It stars Ally Sheedy, Lance Henriksen, Robert Costanzo, Frederic Lehne, John Cassini, and J. D. Daniels.
The Death of the Incredible Hulk is a 1990 American television superhero film, the last of three films based on the 1978–1982 television series The Incredible Hulk. Bill Bixby reprises his role as Dr. David Banner and Lou Ferrigno returns to play the Hulk. It was filmed in Vancouver, British Columbia, Canada. Prior to Bill Bixby's death in 1993, there was talks of The Revenge of the Incredible Hulk television film which would resurrect the character.
Alglucosidase alfa, sold under the brand name Myozyme among others, is an enzyme replacement therapy (ERT) orphan drug for treatment of Pompe disease, a rare lysosomal storage disorder (LSD). Chemically, the drug is an analog of the enzyme that is deficient in patients affected by Pompe disease, alpha-glucosidase. It is the first drug available to treat this disease.
The Oregon Health Plan is Oregon's state Medicaid program. It is overseen by the Oregon Health Authority.
John Francis Crowley is an American biotechnology executive and entrepreneur and the chairman and CEO of Amicus Therapeutics. He co-founded Novazyme Pharmaceuticals with William Canfield, which was later acquired by Genzyme Corporation, and founded Orexigen Therapeutics. In 2006, he was profiled in the book The Cure: How a Father Raised $100 Million – And Bucked the Medical Establishment – In a Quest to Save His Children by Geeta Anand. In 2010, Crowley released his memoir, Chasing Miracles: The Crowley Family Journey of Strength, Hope, and Joy. Crowley and his family were the inspiration for the movie Extraordinary Measures starring Harrison Ford and Brendan Fraser in 2010. Crowley was named CEO of the Biotechnology Innovation Organization, the largest Biotechnology advocacy organization in the world, in 2023.
Cannabis in Oregon is legal for both medical and recreational use. In recent decades, the U.S. state of Oregon has had a number of legislative, legal, and cultural events surrounding use of cannabis. Oregon was the first state to decriminalize the possession of small amounts of cannabis, and among the first to authorize its use for medical purposes. An attempt to recriminalize possession of small amounts of cannabis was turned down by Oregon voters in 1997.
William Canfield is a glycobiologist, chief scientific officer and founder of an Oklahoma City-based biotechnology company, Novazyme, which was acquired by Genzyme in August 2001 and developed, among other things, an enzyme that can stabilize Pompe disease, based on Canfield's ongoing research since 1998. Canfield subsequently left Genzyme and established, with his partner in the Novazyme operation, John Crowley, another research laboratory, which he still heads. He saved Cytovance from bankruptcy by forming an investor group and raising $9 million after Crowley suddenly left the lab in 2005 to become the chief executive officer at Amicus Therapeutics in New Jersey
Oregon is a state in the Pacific Northwest region of the United States. Oregon is a part of the Western United States, with the Columbia River delineating much of Oregon's northern boundary with Washington, while the Snake River delineates much of its eastern boundary with Idaho. The 42° north parallel delineates the southern boundary with California and Nevada. The western boundary is formed by the Pacific Ocean.
Children's Healthcare Is a Legal Duty (CHILD) was from 1983 to 2017 an American nonprofit membership organization that worked to stop child abuse and neglect based on religious beliefs, cultural traditions, and quackery. CHILD opposed religious exemptions from child health and safety laws. These exemptions have been used as a defense in criminal cases when parents have withheld lifesaving medical care on religious grounds. These exemptions also have discouraged reporting and investigation of religion-based medical neglect of children and spawned many outbreaks of vaccine-preventable diseases and deaths. CHILD publicized the ideological abuse and neglect of children, lobbied for equal protection laws for children, and filed lawsuits and amicus curiae briefs in related cases.
Henri A. Termeer was a Dutch biotechnology executive and entrepreneur who is considered a pioneer in corporate strategy in the biotechnology industry for his tenure as CEO at Genzyme. Termeer created a business model adopted by many others in the biotech industry by garnering steep prices— mainly from insurers and government payers— for therapies for rare genetic disorders known as orphan diseases that mainly affect children. Genzyme uses biological processes to manufacture drugs that are not easily copied by generic-drug makers. The drugs are also protected by orphan drug acts in various countries which provides extensive protection from competition and ensures coverage by publicly funded insurers. As CEO of Genzyme from 1981 to 2011, he developed corporate strategies for growth including optimizing institutional embeddedness nurturing vast networks of influential groups and clusters: doctors, private equity, patient-groups, insurance, healthcare umbrella organizations, state and local government, and alumni. Termeer was "connected to 311 board members in 17 different organizations across 20 different industries" He has the legacy of being the "longest-serving CEO in the biotechnology industry.
Ionis Pharmaceuticals, Inc. is a biotechnology company based in Carlsbad, California, that specializes in discovering and developing RNA-targeted therapeutics. The company has three commercially approved medicines: Spinraza (Nusinersen), Tegsedi (Inotersen), and Waylivra (Volanesorsen) and has four drugs in pivotal studies: tominersen for Huntington’s disease, tofersen for SOD1-ALS, AKCEA-APO(a)-LRx for cardiovascular disease, and AKCEA-TTR-LRx for all forms of TTR amyloidosis.
The Biotechnology Innovation Organization (BIO) is the largest advocacy association in the world representing the biotechnology industry. It was founded in 1993 as the Biotechnology Industry Organization from a merger of the Industrial Biotechnology Association (IBA) and the Association of Biotechnology Companies (ABC), and changed its name to the Biotechnology Innovation Organization on January 4, 2016. Biotechnology Innovation Organization serves more than 1,100 biotechnology firms, research schools, state biotechnology centers and related associations in the United States and in more than 30 other countries.
Markus Grompe is a professor of Pediatrics and practicing physician at Oregon Health & Science University. since 1991. Since 2004, he has been director of the Oregon Stem Cell Center at OHSU. Until 2018, he was also director of the Papé Family Pediatric Research Institute, Vice Chair for research in the OHSU department of Pediatrics, and holder of the Ray Hickey Endowed Chair at Doernbecher Children's Hospital.
Yuan-Tsong Chen is a Taiwanese geneticist and physician, notable for his work on human genetic disorders. He is the director emeritus (2001–2010) and distinguished research fellow (2001–present) of the Institute of Biomedical Sciences, Academia Sinica, Taiwan, and also tenured professor of pediatrics of Duke University (1993–present) Chen was a 2019 awardee of Taiwan's Presidential Science Award, as were Yuan-Pern Lee and Wei Fu-chan.
