F-box protein 40

FBXO40
Identifiers
Aliases	FBXO40 , FBX40, F-box protein 40
External IDs	OMIM: 609107 MGI: 2443753 HomoloGene: 9459 GeneCards: FBXO40
Gene location (Human)
Chr.	Chromosome 3 (human)
End	121,630,295 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	36,810,829 bp
RNA expression pattern
	Top expressed in
	vastus lateralis muscle; ; triceps brachii muscle; ; body of tongue; ; right ventricle; ; atrium; ; vena cava; ; gastrocnemius muscle; ; thoracic diaphragm; ; deltoid muscle; ; superior surface of tongue;
	Top expressed in
	skeletal muscle tissue; ; quadriceps femoris muscle; ; secondary oocyte; ; heart; ; zone of skin; ; proximal tubule; ; kidney; ; esophagus; ; lip; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding ; metal ion binding ; ubiquitin protein ligase activity ; ubiquitin-protein transferase activity ; molecular function ;
Cellular component	cytoplasm ; cytosol ;
Biological process	muscle cell differentiation ; protein polyubiquitination ; post-translational protein modification ;
	Sources:Amigo / QuickGO
Orthologs
	51725
	207215
	ENSG00000163833
	ENSMUSG00000047746
	Q9UH90
	P62932
	NM_016298
	NM_001037321 ; NM_001358217
	NP_057382
	NP_001032398 ; NP_001345146
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

F-box protein 40 is a protein that in humans is encoded by the FBXO40 gene. Fbxo40 induces ubiquitination of IRS1, thus limiting activity of IGF1 signaling (Shi et al, 2011).^[5]^[6]

Function

Members of the F-box protein family, such as FBXO40, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.^[7]

Fbxo40 in particular engages a unique substrate, IRS1, which is a protein in the IGF1 signaling pathway. In this way, Fbxo40 causes ubiquitination and degradation of IRS1, blocking further signaling downstream of the IGF1 receptor.^[5]

Related Research Articles

FBXL3 is a gene in humans and mice that encodes the F-box/LRR-repeat protein 3 (FBXL3). FBXL3 is a member of the F-box protein family, which constitutes one of the four subunits in the SCF ubiquitin ligase complex.

Cullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination.

CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1. This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes the covalent attachment of ubiquitin to other proteins.

F-box only protein 7 is a protein that in humans is encoded by the FBXO7 gene. Mutations in FBXO7 have been associated with Parkinson's disease.

F-box only protein 4 is a protein that in humans is encoded by the FBXO4 gene.

F-box/WD repeat-containing protein 2 is a protein that in humans is encoded by the FBXW2 gene.

F-box only protein 11 is a protein that in humans is encoded by the FBXO11 gene.

F-box only protein 2 is a protein that in humans is encoded by the FBXO2 gene.

F-box only protein 9 is a protein that in humans is encoded by the FBXO9 gene.

F-box/WD repeat-containing protein 5 is a protein that in humans is encoded by the FBXW5 gene.

F-box only protein 31 is a protein that in humans is encoded by the FBXO31 gene.

F-box only protein 32, also known as "MAFbx", for "Muscle Atrophy F-box gene", and "Atrogin-1," is a protein that in humans is encoded by the FBXO32 gene.

F-box only protein 28 is a protein that in humans is encoded by the FBXO28 gene.

F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene.

F-box only protein 24 is a protein that in humans is encoded by the FBXO24 gene.

F-box only protein 6 is a protein that in humans is encoded by the FBXO6 gene.

F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene.

S-phase kinase-associated protein 1 is an enzyme that in humans is encoded by the SKP1 gene.

F-box protein 16 is a protein that in humans is encoded by the FBXO16 gene.

F-box protein 15 also known as Fbx15 is a protein that in humans is encoded by the FBXO15 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163833 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047746 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Shi J, Luo L, Eash J, Ibebunjo C, Glass DJ (November 2011). "The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling". Dev Cell. 21 (5): 835–47. doi: 10.1016/j.devcel.2011.09.011 . PMID 22033112.
↑ "Entrez Gene: F-box protein 40" . Retrieved 2017-11-24.
↑ Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW (November 2004). "Systematic analysis and nomenclature of mammalian F-box proteins". Genes & Development. 18 (21): 2573–80. doi:10.1101/gad.1255304. PMC 525538 . PMID 15520277.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163833 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047746 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid22033112-5] 1 2 Shi J, Luo L, Eash J, Ibebunjo C, Glass DJ (November 2011). "The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling". Dev Cell. 21 (5): 835–47. doi: 10.1016/j.devcel.2011.09.011 . PMID 22033112.

[entrez-6] "Entrez Gene: F-box protein 40" . Retrieved 2017-11-24.

[pmid15520277-7] Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW (November 2004). "Systematic analysis and nomenclature of mammalian F-box proteins". Genes & Development. 18 (21): 2573–80. doi:10.1101/gad.1255304. PMC 525538 . PMID 15520277.

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