FAM177A1

FAM177A1
Identifiers
Aliases	FAM177A1 , C14orf24, family with sequence similarity 177 member A1
External IDs	HomoloGene: 27852; GeneCards: FAM177A1; OMA:FAM177A1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q13.2 Start 35,044,907 bp [1] End 35,113,130 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon myocardium of left ventricle left testis right testis corpus callosum C1 segment mucosa of transverse colon rectum right lung upper lobe of left lung n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 283635 n/a Ensembl ENSG00000151327 n/a UniProt Q8N128 n/a RefSeq (mRNA) NM_173607 NM_001079519 NM_001289022 n/a RefSeq (protein) NP_001072987 NP_001275951 NP_775878 n/a Location (UCSC) Chr 14: 35.04 – 35.11 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Family with sequence similarity 177 member A1 (FAM177A1) is a protein that in humans is encoded by the FAM177A1 gene, previously known as C14orf24. ^[3] The other member of this family is FAM177B.

Function

FAM177A1 has been linked to immune system regulation ^[4] and to neurogenesis. ^{[5] [6]}

Interactions

IntAct reports physical interactions between FAM117A1 and these other human proteins: ^[7]

• Aquaporin-6
• Caspase 6
• DPM3
• ELOVL4
• FATE1
• JAGN1
• LAMP2
• PBX3
• SGPL1
• SH3GLB1
• TMX2

References

1. GRCh38: Ensembl release 89: ENSG00000151327 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "FAM177A1 family with sequence similarity 177 member A1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-08-24.
4. Liao, Bo-Wei; Zhang, Hong-Yan; Du, Wen-Tian; Ran, Yong; Wang, Yan-Yi; Xu, Zhi-Sheng (2021-12-15). "FAM177A1 Inhibits IL-1β-Induced Signaling by Impairing TRAF6-Ubc13 Association". Journal of Immunology. 207 (12): 3090–3097. doi: 10.4049/jimmunol.2100561 . ISSN   1550-6606. PMID   34799425. S2CID   244428716.
5. Ko, Hae Young; Lee, Dong Soo; Kim, Soonhag (2009-08-08). "Noninvasive imaging of microRNA124a-mediated repression of the chromosome 14 ORF 24 gene during neurogenesis". The FEBS Journal. 276 (17): 4854–4865. doi:10.1111/j.1742-4658.2009.07185.x. ISSN   1742-4658. PMID   19663910. S2CID   205881038.
6. Alazami, Anas M.; Patel, Nisha; Shamseldin, Hanan E.; Anazi, Shamsa; Al-Dosari, Mohammed S.; Alzahrani, Fatema; Hijazi, Hadia; Alshammari, Muneera; Aldahmesh, Mohammed A.; Salih, Mustafa A.; Faqeih, Eissa; Alhashem, Amal; Bashiri, Fahad A.; Al-Owain, Mohammed; Kentab, Amal Y. (2015-01-13). "Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families". Cell Reports. 10 (2): 148–161. doi: 10.1016/j.celrep.2014.12.015 . ISSN   2211-1247. PMID   25558065.
7. "IntAct Portal". www.ebi.ac.uk. Retrieved 2022-08-26.

External links

• FAM177A1 Research Fund (for FAM177A1 Associated Disease)