FBXL7

FBXL7
Identifiers
Aliases	FBXL7 , FBL6, FBL7, F-box and leucine-rich repeat protein 7, F-box and leucine rich repeat protein 7
External IDs	OMIM: 605656 MGI: 3052506 HomoloGene: 69121 GeneCards: FBXL7
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5p15.1 Start 15,500,180 bp [1] End 15,939,795 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 B1 Start 26,540,545 bp [2] End 26,895,666 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte saphenous vein urethra tibia vena cava embryo myometrium trigeminal ganglion ganglionic eminence olfactory bulb Top expressed in hand vas deferens belly cord endocardial cushion renal corpuscle molar secondary oocyte medullary collecting duct body of femur stria vascularis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin-protein transferase activity Cellular component cytoplasm ubiquitin ligase complex microtubule organizing center centrosome SCF ubiquitin ligase complex cytoskeleton cytosol Biological process cell division cell cycle cell population proliferation G2/M transition of mitotic cell cycle protein ubiquitination ubiquitin-dependent protein catabolic process protein polyubiquitination SCF complex assembly negative regulation of G2/M transition of mitotic cell cycle SCF-dependent proteasomal ubiquitin-dependent protein catabolic process mitotic cell cycle post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23194 448987 Ensembl ENSG00000183580 ENSMUSG00000043556 UniProt Q9UJT9 Q5BJ29 RefSeq (mRNA) NM_001278317 NM_012304 NM_176959 RefSeq (protein) NP_001265246 NP_036436 NP_795933 Location (UCSC) Chr 5: 15.5 – 15.94 Mb Chr 15: 26.54 – 26.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

F-box/LRR-repeat protein 7 is a protein that in humans is encoded by the FBXL7 gene. ^{[5] [6] [7]}

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.

The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000183580 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043556 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID   10048485.
6. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi: 10.1016/S0960-9822(00)80020-2 . PMID   10531035. S2CID   7467493.
7. "Entrez Gene: FBXL7 F-box and leucine-rich repeat protein 7".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2. doi: 10.1016/S0960-9822(00)80021-4 . PMID   10531037. S2CID   14341845.
• Ilyin GP, Rialland M, Pigeon C, Guguen-Guillouzo C (2001). "cDNA cloning and expression analysis of new members of the mammalian F-box protein family". Genomics. 67 (1): 40–7. doi:10.1006/geno.2000.6211. PMID   10945468.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Watanabe N, Arai H, Nishihara Y, et al. (2004). "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4419–24. Bibcode:2004PNAS..101.4419W. doi: 10.1073/pnas.0307700101 . PMC   384762 . PMID   15070733.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Venables JP, Bourgeois CF, Dalgliesh C, et al. (2005). "Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon". Hum. Mol. Genet. 14 (16): 2289–303. doi:10.1093/hmg/ddi233. PMID   16000324.