FBXO9

FBXO9
Identifiers
Aliases	FBXO9 , FBX9, NY-REN-57, VCIA1, dJ341E18.2, F-box protein 9
External IDs	OMIM: 609091; MGI: 1918788; HomoloGene: 8217; GeneCards: FBXO9; OMA:FBXO9 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p12.1 Start 53,051,991 bp [1] End 53,100,873 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 E1 Start 77,988,781 bp [2] End 78,016,347 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus right adrenal gland right adrenal cortex secondary oocyte left adrenal gland trabecular bone left adrenal cortex tibia Top expressed in medial vestibular nucleus blood ciliary body retinal pigment epithelium dorsal tegmental nucleus pontine nuclei deep cerebellar nuclei motor neuron medial geniculate nucleus ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin-protein transferase activity Cellular component cytoplasm ubiquitin ligase complex SCF ubiquitin ligase complex cytosol Biological process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process innate immune response regulation of TOR signaling fat cell differentiation protein ubiquitination protein polyubiquitination post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26268 71538 Ensembl ENSG00000112146 ENSMUSG00000001366 UniProt Q9UK97 Q8BK06 RefSeq (mRNA) NM_012347 NM_033480 NM_033481 NM_001081490 NM_023605 RefSeq (protein) NP_036479 NP_258441 NP_258442 NP_001074959 NP_076094 Location (UCSC) Chr 6: 53.05 – 53.1 Mb Chr 9: 77.99 – 78.02 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

F-box only protein 9 is a protein that in humans is encoded by the FBXO9 gene. ^{[5] [6] [7]}

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000112146 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001366 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi: 10.1016/S0960-9822(00)80020-2 . PMID   10531035. S2CID   7467493.
6. Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi: 10.1016/S0960-9822(00)80021-4 . PMID   10531037. S2CID   14341845.
7. "Entrez Gene: FBXO9 F-box protein 9".

Further reading

• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID   8889549.
• Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID   10508479. S2CID   21839750.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Jin J, Cardozo T, Lovering RC, et al. (2005). "Systematic analysis and nomenclature of mammalian F-box proteins". Genes Dev. 18 (21): 2573–80. doi:10.1101/gad.1255304. PMC   525538 . PMID   15520277.