FBXW8

FBXW8
Identifiers
Aliases	FBXW8 , FBW6, FBW8, FBX29, FBXO29, FBXW6, F-box and WD repeat domain containing 8
External IDs	OMIM: 609073 MGI: 1923041 HomoloGene: 17731 GeneCards: FBXW8
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q24.22 Start 116,910,950 bp [1] End 117,031,148 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 F Start 118,203,030 bp [2] End 118,293,529 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium bone marrow cells islet of Langerhans ganglionic eminence popliteal artery gastric mucosa smooth muscle tissue body of pancreas anterior pituitary left lobe of thyroid gland Top expressed in otic placode saccule interventricular septum internal carotid artery external carotid artery somite calvaria yolk sac autopod region foot More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin-protein transferase activity Cellular component perinuclear region of cytoplasm Golgi apparatus Cul7-RING ubiquitin ligase complex SCF ubiquitin ligase complex 3M complex cytoplasm cytosol Biological process cell population proliferation positive regulation of dendrite morphogenesis spongiotrophoblast layer development labyrinthine layer blood vessel development Golgi organization protein ubiquitination protein polyubiquitination post-translational protein modification positive regulation of transcription factor catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26259 231672 Ensembl ENSG00000174989 ENSMUSG00000032867 UniProt Q8N3Y1 Q8BIA4 RefSeq (mRNA) NM_012174 NM_153348 NM_172721 RefSeq (protein) NP_036306 NP_699179 NP_766309 Location (UCSC) Chr 12: 116.91 – 117.03 Mb Chr 5: 118.2 – 118.29 Mb PubMed search [3] [4]
Wikidata
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F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene. ^{[5] [6] [7]}

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin-protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000174989 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032867 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi: 10.1016/S0960-9822(00)80020-2 . PMID   10531035. S2CID   7467493.
6. Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. doi: 10.1016/S0960-9822(00)80021-4 . PMID   10531037. S2CID   14341845.
7. "Entrez Gene: FBXW8 F-box and WD repeat domain containing 8".

Further reading

• Tsutsumi T, Kuwabara H, Arai T, et al. (2008). "Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice". Mol. Cell. Biol. 28 (2): 743–51. doi:10.1128/MCB.01665-07. PMC   2223430 . PMID   17998335.
• Koch HB, Zhang R, Verdoodt B, et al. (2007). "Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach". Cell Cycle. 6 (2): 205–17. doi: 10.4161/cc.6.2.3742 . PMID   17314511.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Watanabe N, Arai H, Nishihara Y, et al. (2004). "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4419–24. Bibcode:2004PNAS..101.4419W. doi: 10.1073/pnas.0307700101 . PMC   384762 . PMID   15070733.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Dias DC, Dolios G, Wang R, Pan ZQ (2003). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16601–6. doi: 10.1073/pnas.252646399 . PMC   139190 . PMID   12481031.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.