FCHO1

FCHO1
Identifiers
Aliases	FCHO1 , FCH domain only 1, FCH and mu domain containing endocytic adaptor 1
External IDs	OMIM: 613437 MGI: 1921265 HomoloGene: 22869 GeneCards: FCHO1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	17,788,568 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	72,178,360 bp
RNA expression pattern
	Top expressed in
	oocyte; ; blood; ; lymph node; ; monocyte; ; putamen; ; prefrontal cortex; ; amygdala; ; corpus callosum; ; caudate nucleus; ; Brodmann area 9;
	Top expressed in
	superior frontal gyrus; ; thymus; ; entorhinal cortex; ; cerebellar cortex; ; primary motor cortex; ; olfactory tubercle; ; globus pallidus; ; superior colliculus; ; lip; ; inferior colliculus;
	More reference expression data
	n/a
Gene ontology
Molecular function	AP-2 adaptor complex binding ; protein binding ; phospholipid binding ; microtubule binding ; cytoskeletal protein binding ; tubulin binding ;
Cellular component	plasma membrane ; clathrin-coated pit ; membrane ; clathrin-coated vesicle ; nucleoplasm ; cytosol ; cytoplasm ; cytoskeleton ; AP-2 adaptor complex ;
Biological process	clathrin-dependent endocytosis ; endocytosis ; clathrin coat assembly ; membrane organization ; plasma membrane tubulation ;
	Sources:Amigo / QuickGO
Orthologs
	23149
	74015
	ENSG00000130475
	ENSMUSG00000070000
	O14526
	Q8K285
	NM_001161357 ; NM_001161358 ; NM_001161359 ; NM_015122
	NM_028715
	NP_001154829 ; NP_001154830 ; NP_001154831 ; NP_055937
	NP_082991
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 26, 2023

FCH domain only 1 is a protein that in humans is encoded by the FCHO1 gene. ^[5]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000130475 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070000 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: FCH domain only 1" . Retrieved 2017-05-13.

Sakaushi S, Inoue K, Zushi H, Senda-Murata K, Fukada T, Oka S, Sugimoto K (2007). "Dynamic behavior of FCHO1 revealed by live-cell imaging microscopy: its possible involvement in clathrin-coated vesicle formation". Biosci. Biotechnol. Biochem. 71 (7): 1764–8. doi:10.1271/bbb.60720. PMID 17617719. S2CID 21432830.
Henne WM, Boucrot E, Meinecke M, Evergren E, Vallis Y, Mittal R, McMahon HT (2010). "FCHo proteins are nucleators of clathrin-mediated endocytosis". Science. 328 (5983): 1281–4. doi:10.1126/science.1188462. PMC 2883440 . PMID 20448150.
Umasankar PK, Sanker S, Thieman JR, Chakraborty S, Wendland B, Tsang M, Traub LM (2012). "Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning". Nat. Cell Biol. 14 (5): 488–501. doi:10.1038/ncb2473. PMC 3354769 . PMID 22484487.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000130475 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070000 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FCH domain only 1" . Retrieved 2017-05-13.

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FCHO1

Related Research Articles

References

Further reading