FEM1A

FEM1A
Identifiers
Aliases	FEM1A , EPRAP, fem-1 homolog A
External IDs	OMIM: 613538; MGI: 1335089; HomoloGene: 7713; GeneCards: FEM1A; OMA:FEM1A - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.3 Start 4,791,734 bp [1] End 4,801,273 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 D|17 29.24 cM Start 56,563,810 bp [2] End 56,570,610 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis tibialis anterior muscle quadriceps femoris muscle vastus lateralis muscle biceps brachii Skeletal muscle tissue of biceps brachii myocardium of left ventricle deltoid muscle body of tongue cardiac muscle tissue of right atrium Top expressed in extensor digitorum longus muscle plantaris muscle muscle of thigh cardiac muscle tissue of left ventricle gastrocnemius muscle triceps brachii muscle medial head of gastrocnemius muscle tibialis anterior muscle temporal muscle skeletal muscle tissue More reference expression data BioGPS n/a
Gene ontology Molecular function EP4 subtype prostaglandin E2 receptor binding ubiquitin-protein transferase activity Cellular component cytoplasm cytosol Biological process negative regulation of inflammatory response protein ubiquitination regulation of ubiquitin-protein transferase activity post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55527 14154 Ensembl ENSG00000141965 ENSMUSG00000043683 UniProt Q9BSK4 Q9Z2G1 RefSeq (mRNA) NM_018708 NM_010192 RefSeq (protein) NP_061178 NP_034322 Location (UCSC) Chr 19: 4.79 – 4.8 Mb Chr 17: 56.56 – 56.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Fem-1 homolog A is a protein that in humans is encoded by the FEM1A gene. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000141965 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043683 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Fem-1 homolog A" . Retrieved 2018-09-21.

Further reading

• Ventura-Holman T, Hahn H, Subauste JS, Maher JF (2005). "The Fem1a gene is downregulated in Rhabdomyosarcoma". Tumour Biol. 26 (6): 294–9. doi:10.1159/000089261. PMID   16254458. S2CID   2202410.
• Maher JF, Hines RS, Futterweit W, Crawford S, Lu D, Shen P, Oefner P, Kazi M, Wilson JG, Subauste JS, Cowan BD (December 2005). "FEM1A is a candidate gene for polycystic ovary syndrome". Gynecol. Endocrinol. 21 (6): 330–5. doi:10.1080/09513590500431458. PMID   16390781. S2CID   24793473.
• Minami M, Shimizu K, Okamoto Y, Folco E, Ilasaca ML, Feinberg MW, Aikawa M, Libby P (April 2008). "Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation". J. Biol. Chem. 283 (15): 9692–703. doi: 10.1074/jbc.M709663200 . PMC   2442287 . PMID   18270204.
• Goodarzi MO, Maher JF, Cui J, Guo X, Taylor KD, Azziz R (December 2008). "FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome". Hum. Reprod. 23 (12): 2842–9. doi:10.1093/humrep/den324. PMC   2583941 . PMID   18757445.
• Goodarzi MO, Maher JF, Cui J, Guo X, Taylor KD, Azziz R (December 2008). "FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome". Hum. Reprod. 23 (12): 2842–9. doi:10.1093/humrep/den324. PMC   2583941 . PMID   18757445.
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC   2775832 . PMID   19913121.
• McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF (December 2009). "Integrative predictive model of coronary artery calcification in atherosclerosis". Circulation. 120 (24): 2448–54. doi:10.1161/CIRCULATIONAHA.109.865501. PMC   2810344 . PMID   19948975.
• Ewens KG, Stewart DR, Ankener W, Urbanek M, McAllister JM, Chen C, Baig KM, Parker SC, Margulies EH, Legro RS, Dunaif A, Strauss JF, Spielman RS (May 2010). "Family-based analysis of candidate genes for polycystic ovary syndrome". J. Clin. Endocrinol. Metab. 95 (5): 2306–15. doi:10.1210/jc.2009-2703. PMC   2869537 . PMID   20200332.
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC   2945168 . PMID   20628086.