FHL5

FHL5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X68
Identifiers
Aliases	FHL5 , ACT, dJ393D12.2, 1700027G07Rik, FHL-5, four and a half LIM domains 5
External IDs	OMIM: 605126 MGI: 1913192 HomoloGene: 23230 GeneCards: FHL5
Gene location (Human)
Chr.	Chromosome 6 (human)
End	96,618,626 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	25,242,876 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; right coronary artery; ; sperm; ; left coronary artery; ; pericardium; ; Achilles tendon; ; saphenous vein; ; superficial temporal artery; ; subcutaneous adipose tissue; ; ascending aorta;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; male urethra; ; secondary oocyte; ; esophagus; ; skeletal muscle tissue; ; jejunum; ; islet of Langerhans; ; uterus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity ; protein binding ; metal ion binding ;
Cellular component	nucleus ; Z disc ;
Biological process	positive regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	9457
	57756
	ENSG00000112214
	ENSMUSG00000028259
	Q5TD97
	Q9WTX7
	NM_001170807 ; NM_020482 ; NM_001322466 ; NM_001322467
	NM_021318 ; NM_001355498 ; NM_001379528
	NP_001164278 ; NP_001309395 ; NP_001309396 ; NP_065228
	NP_067293 ; NP_001342427 ; NP_001366457
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Four and a half LIM domains protein 5 is a protein that in humans is encoded by the FHL5 gene.^[5]

Function

The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene.^[5]

Interactions

FHL5 has been shown to interact with CREB1 ^[6] and CAMP responsive element modulator.^[6]^[7]

Related Research Articles

CREB-TF is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene.

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CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene. This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription.

Four and a half LIM domains protein 2 also known as FHL-2 is a protein that in humans is encoded by the FHL2 gene. LIM proteins contain a highly conserved double zinc finger motif called the LIM domain.

Activating transcription factor 4 , also known as ATF4, is a protein that in humans is encoded by the ATF4 gene.

Calcium/calmodulin-dependent protein kinase type II gamma chain is an enzyme that in humans is encoded by the CAMK2G gene.

Activating transcription factor 2, also known as ATF2, is a protein that, in humans, is encoded by the ATF2 gene.

protein S6 kinase, 90kDa, polypeptide 3, also s RPS6KA3, is an enzyme that in humans is encoded by the RPS6KA3 gene.

cAMP responsive element modulator is a protein that in humans is encoded by the CREM gene, and it belongs to the cAMP-responsive element binding protein family. It has multiple isoforms, which act either as repressors or activators. CREB family is important for in regulating transcription in response to various stresses, metabolic and developmental signals. CREM transcription factors also play an important role in many physiological systems, such as cardiac function, circadian rhythms, locomotion and spermatogenesis.

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene. This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes.

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C-terminal-binding protein 2 also known as CtBP2 is a protein that in humans is encoded by the CTBP2 gene.

Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the NFE2 gene.

Cyclic AMP-responsive element-binding protein 3 is a protein that in humans is encoded by the CREB3 gene.

Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.

Four and a half LIM domains protein 3 is a protein that in humans is encoded by the FHL3 gene.

Krüppel-like factor 3 is a protein that in humans is encoded by the KLF3 gene.

Kinesin-like protein KIF17 is a protein that in humans is encoded by the KIF17 gene. KIF17 and its close relative, C. elegans OSM-3, are members of the kinesin-2 family of plus-end directed microtubule-based motor proteins. In contrast to heterotrimeric kinesin-2 motors, however, KIF17 and OSM-3 form distinct homodimeric complexes. Homodimeric kinesin-2 has been implicated in the transport of NMDA receptors along dendrites for delivery to the dendritic membrane, whereas both heterotrimeric and homodimeric kinesin-2 motors function cooperatively in anterograde intraflagellar transport (IFT) and cilium biogenesis.

The Basic Leucine Zipper Domain is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required to hold together (dimerize) two DNA binding regions. The DNA binding region comprises a number of basic amino acids such as arginine and lysine. Proteins containing this domain are transcription factors.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000112214 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028259 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: FHL5 four and a half LIM domains 5".
1 2 Fimia GM, De Cesare D, Sassone-Corsi P (November 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. 20 (22): 8613–22. doi:10.1128/MCB.20.22.8613-8622.2000. PMC 102166 . PMID 11046156.
↑ Fimia GM, De Cesare D, Sassone-Corsi P (March 1999). "CBP-independent activation of CREM and CREB by the LIM-only protein ACT". Nature. 398 (6723): 165–9. Bibcode:1999Natur.398..165F. doi:10.1038/18237. PMID 10086359. S2CID 4424908.

External links

FHL5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000112214 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028259 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: FHL5 four and a half LIM domains 5".

[pmid11046156-6] 1 2 Fimia GM, De Cesare D, Sassone-Corsi P (November 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. 20 (22): 8613–22. doi:10.1128/MCB.20.22.8613-8622.2000. PMC 102166 . PMID 11046156.

[pmid10086359-7] Fimia GM, De Cesare D, Sassone-Corsi P (March 1999). "CBP-independent activation of CREM and CREB by the LIM-only protein ACT". Nature. 398 (6723): 165–9. Bibcode:1999Natur.398..165F. doi:10.1038/18237. PMID 10086359. S2CID 4424908.

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