FHL5

FHL5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X68
Identifiers
Aliases	FHL5 , ACT, dJ393D12.2, 1700027G07Rik, FHL-5, four and a half LIM domains 5
External IDs	OMIM: 605126; MGI: 1913192; HomoloGene: 23230; GeneCards: FHL5; OMA:FHL5 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q16.1 Start 96,562,548 bp [1] End 96,618,626 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 A3 Start 25,199,908 bp [2] End 25,242,876 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries right coronary artery sperm left coronary artery right testis left testis pericardium Achilles tendon Descending thoracic aorta Top expressed in seminiferous tubule spermatid spermatocyte male urethra muscle of thigh secondary oocyte esophagus zygote primary oocyte skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity protein binding metal ion binding Cellular component nucleus Z discdkac Biological process positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9457 57756 Ensembl ENSG00000112214 ENSMUSG00000028259 UniProt Q5TD97 Q9WTX7 RefSeq (mRNA) NM_001170807 NM_020482 NM_001322466 NM_001322467 NM_021318 NM_001355498 NM_001379528 RefSeq (protein) NP_001164278 NP_001309395 NP_001309396 NP_065228 NP_067293 NP_001342427 NP_001366457 Location (UCSC) Chr 6: 96.56 – 96.62 Mb Chr 4: 25.2 – 25.24 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Four and a half LIM domains protein 5 is a protein that in humans is encoded by the FHL5 gene. ^[5]

Function

The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. ^[5]

Interactions

FHL5 has been shown to interact with CREB1 ^[6] and CAMP responsive element modulator. ^{[6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000112214 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028259 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: FHL5 four and a half LIM domains 5".
6. Fimia GM, De Cesare D, Sassone-Corsi P (November 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. 20 (22): 8613–22. doi:10.1128/MCB.20.22.8613-8622.2000. PMC   102166 . PMID   11046156.
7. Fimia GM, De Cesare D, Sassone-Corsi P (March 1999). "CBP-independent activation of CREM and CREB by the LIM-only protein ACT". Nature. 398 (6723): 165–9. Bibcode:1999Natur.398..165F. doi:10.1038/18237. PMID   10086359. S2CID   4424908.

Further reading

• Fimia GM, Morlon A, Macho B, De Cesare D, Sassone-Corsi P (2001). "Transcriptional cascades during spermatogenesis: pivotal role of CREM and ACT". Mol. Cell. Endocrinol. 179 (1–2): 17–23. doi:10.1016/S0303-7207(01)00463-4. PMID   11420126. S2CID   34999951.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Fimia GM, De Cesare D, Sassone-Corsi P (1999). "CBP-independent activation of CREM and CREB by the LIM-only protein ACT". Nature. 398 (6723): 165–9. Bibcode:1999Natur.398..165F. doi:10.1038/18237. PMID   10086359. S2CID   4424908.
• Fimia GM, De Cesare D, Sassone-Corsi P (2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. 20 (22): 8613–22. doi:10.1128/MCB.20.22.8613-8622.2000. PMC   102166 . PMID   11046156.
• Palermo I, Litrico L, Emmanuele G, Giuffrida V, Sassone-Corsi P, De Cesare D, Maria Fimia G, D'Agata R, Calogero AE, Travali S (2001). "Cloning and expression of activator of CREM in testis in human testicular tissue". Biochem. Biophys. Res. Commun. 283 (2): 406–11. doi:10.1006/bbrc.2001.4805. PMID   11327716.
• Peri A, Luciani P, Tonacchera M, Agretti P, Baglioni-Peri S, Buci L, Conforti B, Cioppi F, Biliotti G, Serio M, Vitti P, Chiovato L (2002). "Expression of cAMP-responsive element binding protein and inducible cAMP early repressor in hyperfunctioning thyroid adenomas". Eur. J. Endocrinol. 146 (6): 759–66. doi: 10.1530/eje.0.1460759 . PMID   12039695.
• Macho B, Brancorsini S, Fimia GM, Setou M, Hirokawa N, Sassone-Corsi P (2002). "CREM-dependent transcription in male germ cells controlled by a kinesin". Science. 298 (5602): 2388–90. Bibcode:2002Sci...298.2388M. doi:10.1126/science.1077265. PMID   12493914. S2CID   42448155.
• Philippar U, Schratt G, Dieterich C, Müller JM, Galgóczy P, Engel FB, Keating MT, Gertler F, Schüle R, Vingron M, Nordheim A (2004). "The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF". Mol. Cell. 16 (6): 867–80. doi:10.1016/j.molcel.2004.11.039. hdl: 1721.1/83480 . PMID   15610731.
• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Christensen GL, Wooding SP, Ivanov IP, Atkins JF, Carrell DT (2006). "Sequencing and haplotype analysis of the activator of CREM in the testis (ACT) gene in populations of fertile and infertile males". Mol. Hum. Reprod. 12 (4): 257–62. doi: 10.1093/molehr/gal006 . PMID   16687568.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.

External links

• FHL5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.