FLII

FLII
Identifiers
Aliases	FLII , FLI, FLIL, Fli1, actin remodeling protein, FLII actin remodeling protein
External IDs	OMIM: 600362; MGI: 1342286; HomoloGene: 11092; GeneCards: FLII; OMA:FLII - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	18,258,738 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	60,618,089 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; muscle of thigh; ; gastrocnemius muscle; ; skeletal muscle tissue; ; spleen; ; mucosa of transverse colon; ; Pituitary Gland; ; anterior pituitary; ; minor salivary glands; ; right lobe of thyroid gland;
	Top expressed in
	Ileal epithelium; ; choroid plexus of fourth ventricle; ; granulocyte; ; cardiac muscle tissue of left ventricle; ; lactiferous gland; ; tracheobronchial tree; ; internal carotid artery; ; mesenteric lymph nodes; ; right lung lobe; ; muscle of thigh;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	actin binding ; protein binding ; actin filament binding ;
Cellular component	cell junction ; cytoskeleton ; brush border ; nucleus ; focal adhesion ; nucleoplasm ; microtubule organizing center ; cytoplasm ; cytosol ;
Biological process	multicellular organism development ; actin filament severing ; regulation of transcription, DNA-templated ; actin cytoskeleton organization ; transcription, DNA-templated ;
	Sources:Amigo / QuickGO
Orthologs
	2314
	14248
	ENSG00000177731 ; ENSG00000284571
	ENSMUSG00000002812
	Q13045
	Q9JJ28
	NM_001256264 ; NM_001256265 ; NM_002018
	NM_022009 ; NM_001302207
	NP_001243193 ; NP_001243194 ; NP_002009
	NP_001289136 ; NP_071292
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 29, 2024

Protein flightless-1 homolog is a protein that in humans is encoded by the FLII gene.^[5]^[6]

This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain.^[7] The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.^[6]

Interactions

FLII has been shown to interact with LRRFIP1 ^[8]^[9] and TRAF interacting protein.^[10]

Related Research Articles

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TRAF-interacting protein is a protein that in humans is encoded by the TRAIP gene.

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LRRIQ3, which is also known as LRRC44, is a protein that in humans is encoded by the LRRIQ3 gene. It is predominantly expressed in the testes, and is linked to a number of diseases.

References

1 2 3 ENSG00000284571 GRCh38: Ensembl release 89: ENSG00000177731, ENSG00000284571 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002812 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Chen KS, Gunaratne PH, Hoheisel JD, Young IG, Miklos GL, Greenberg F, Shaffer LG, Campbell HD, Lupski JR (Feb 1995). "The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2". Am J Hum Genet. 56 (1): 175–82. PMC 1801336 . PMID 7825574.
1 2 "Entrez Gene: FLII flightless I homolog (Drosophila)".
↑ Ghoshdastider U, Popp D, Burtnick LD, Robinson RC (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256. S2CID 205643538.
↑ Liu, Y T; Yin H L (Apr 1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J. Biol. Chem. 273 (14): 7920–7. doi: 10.1074/jbc.273.14.7920 . ISSN 0021-9258. PMID 9525888.
↑ Fong, K S; de Couet H G (Jun 1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. ISSN 0888-7543. PMID 10366446.
↑ Wilson, S A; Brown E C; Kingsman A J; Kingsman S M (Aug 1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Res. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. ISSN 0305-1048. PMC 147727 . PMID 9671805.

Campbell HD, Schimansky T, Claudianos C, et al. (1994). "The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11386–90. Bibcode:1993PNAS...9011386C. doi: 10.1073/pnas.90.23.11386 . PMC 47987 . PMID 8248259.
Campbell HD, Fountain S, Young IG, et al. (1997). "Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL". Genomics. 42 (1): 46–54. doi:10.1006/geno.1997.4709. PMID 9177775.
Liu YT, Yin HL (1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J. Biol. Chem. 273 (14): 7920–7. doi: 10.1074/jbc.273.14.7920 . PMID 9525888.
Wilson SA, Brown EC, Kingsman AJ, Kingsman SM (1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I." Nucleic Acids Res. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. PMC 147727 . PMID 9671805.
Fong KS, de Couet HG (1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. PMID 10366446.
Davy DA, Campbell HD, Fountain S, et al. (2001). "The flightless I protein colocalizes with actin- and microtubule-based structures in motile Swiss 3T3 fibroblasts: evidence for the involvement of PI 3-kinase and Ras-related small GTPases". J. Cell Sci. 114 (Pt 3): 549–62. doi:10.1242/jcs.114.3.549. PMID 11171324.
Campbell HD, Fountain S, McLennan IS, et al. (2002). "Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development". Mol. Cell. Biol. 22 (10): 3518–26. doi:10.1128/MCB.22.10.3518-3526.2002. PMC 133791 . PMID 11971982.
Bi W, Yan J, Stankiewicz P, et al. (2002). "Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMC 186594 . PMID 11997338.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Lee YH, Campbell HD, Stallcup MR (2004). "Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity". Mol. Cell. Biol. 24 (5): 2103–17. doi:10.1128/MCB.24.5.2103-2117.2004. PMC 350567 . PMID 14966289.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wang T, Chuang TH, Ronni T, et al. (2006). "Flightless I homolog negatively modulates the TLR pathway". J. Immunol. 176 (3): 1355–62. doi: 10.4049/jimmunol.176.3.1355 . PMID 16424162.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000284571 GRCh38: Ensembl release 89: ENSG00000177731, ENSG00000284571 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002812 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7825574-5] Chen KS, Gunaratne PH, Hoheisel JD, Young IG, Miklos GL, Greenberg F, Shaffer LG, Campbell HD, Lupski JR (Feb 1995). "The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2". Am J Hum Genet. 56 (1): 175–82. PMC 1801336 . PMID 7825574.

[entrez-6] 1 2 "Entrez Gene: FLII flightless I homolog (Drosophila)".

[pmid24155256-7] Ghoshdastider U, Popp D, Burtnick LD, Robinson RC (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256. S2CID 205643538.

[pmid9525888-8] Liu, Y T; Yin H L (Apr 1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J. Biol. Chem. 273 (14): 7920–7. doi: 10.1074/jbc.273.14.7920 . ISSN 0021-9258. PMID 9525888.

[pmid10366446-9] Fong, K S; de Couet H G (Jun 1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. ISSN 0888-7543. PMID 10366446.

[pmid9671805-10] Wilson, S A; Brown E C; Kingsman A J; Kingsman S M (Aug 1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Res. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. ISSN 0305-1048. PMC 147727 . PMID 9671805.

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FLII

Contents

Interactions

Related Research Articles

References

Further reading