FLOT1

FLOT1
Identifiers
Aliases	FLOT1 , flotillin 1
External IDs	OMIM: 606998 MGI: 1100500 HomoloGene: 31337 GeneCards: FLOT1
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p21.33 Start 30,727,709 bp [1] End 30,742,732 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 B1 Start 36,134,122 bp [2] End 36,143,683 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland left adrenal gland blood dorsolateral prefrontal cortex left ventricle cerebellum cerebellar cortex cerebellar hemisphere Brodmann area 9 superior frontal gyrus Top expressed in interventricular septum right ventricle ankle joint sciatic nerve facial motor nucleus spinal ganglia visual cortex prefrontal cortex plantaris muscle entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protease binding protein binding protein heterodimerization activity ionotropic glutamate receptor binding Cellular component integral component of membrane endosome membrane cell-cell contact zone focal adhesion plasma membrane raft melanosome plasma membrane centriolar satellite microtubule organizing center lysosomal membrane flotillin complex uropod basolateral plasma membrane early endosome apical plasma membrane cortical actin cytoskeleton caveola membrane raft COP9 signalosome sarcolemma extracellular exosome cytoplasmic vesicle lamellipodium cell-cell junction external side of plasma membrane synapse presynaptic active zone dopaminergic synapse presynapse glutamatergic synapse GABA-ergic synapse Biological process positive regulation of cell-cell adhesion mediated by cadherin positive regulation of cell adhesion molecule production positive regulation of protein phosphorylation regulation of toll-like receptor 4 signaling pathway positive regulation of heterotypic cell-cell adhesion positive regulation of toll-like receptor 3 signaling pathway axonogenesis positive regulation of skeletal muscle tissue development positive regulation of cytokine production extracellular matrix disassembly protein kinase C signaling response to endoplasmic reticulum stress positive regulation of myoblast fusion positive regulation of endocytosis positive regulation of cell junction assembly protein localization to membrane raft membrane raft assembly cellular response to exogenous dsRNA regulation of receptor internalization positive regulation of synaptic transmission, dopaminergic positive regulation of protein binding regulation of Rho protein signal transduction protein homooligomerization dsRNA transport plasma membrane raft assembly positive regulation of interferon-beta production protein stabilization protein localization to plasma membrane regulation of neurotransmitter uptake positive regulation of NF-kappaB transcription factor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10211 14251 Ensembl ENSG00000137312 ENSG00000232280 ENSG00000224740 ENSG00000206480 ENSG00000206379 ENSG00000230143 ENSG00000236271 ENSG00000223654 ENSMUSG00000059714 UniProt O75955 O08917 RefSeq (mRNA) NM_005803 NM_001318875 NM_008027 RefSeq (protein) NP_001305804 NP_005794 NP_032053 Location (UCSC) Chr 6: 30.73 – 30.74 Mb Chr 17: 36.13 – 36.14 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Flotillin-1 is a protein that in humans is encoded by the FLOT1 gene. ^[5]

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein. ^[6] The function of flotillin 1 has not been determined. ^[5]

Interactions

FLOT1 has been shown to interact with SORBS1. ^{[7] [8] [9]}

References

1. ENSG00000232280, ENSG00000224740, ENSG00000206480, ENSG00000206379, ENSG00000230143, ENSG00000236271, ENSG00000223654 GRCh38: Ensembl release 89: ENSG00000137312, ENSG00000232280, ENSG00000224740, ENSG00000206480, ENSG00000206379, ENSG00000230143, ENSG00000236271, ENSG00000223654 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059714 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: FLOT1 flotillin 1".
6. Bickel PE, Scherer PE, Schnitzer JE, Oh P, Lisanti MP, Lodish HF (May 1997). "Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins". J. Biol. Chem. 272 (21): 13793–802. doi: 10.1074/jbc.272.21.13793 . PMID   9153235.
7. Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I (May 2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell Sci. 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. PMID   15128873. S2CID   14083271.
8. Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR (September 2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport" (PDF). Nature. 407 (6801): 202–7. Bibcode:2000Natur.407..202B. doi:10.1038/35025089. hdl: 2027.42/62940 . PMID   11001060. S2CID   4334519.
9. Kimura A, Baumann CA, Chiang SH, Saltiel AR (July 2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. Bibcode:2001PNAS...98.9098K. doi: 10.1073/pnas.151252898 . PMC   55379 . PMID   11481476.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Volonte D, Galbiati F, Li S, et al. (1999). "Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe". J. Biol. Chem. 274 (18): 12702–9. doi: 10.1074/jbc.274.18.12702 . PMID   10212252.
• Hazarika P, Dham N, Patel P, et al. (1999). "Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation". J. Cell. Biochem. 75 (1): 147–59. doi:10.1002/(SICI)1097-4644(19991001)75:1<147::AID-JCB15>3.0.CO;2-D. PMID   10462713. S2CID   12223151.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.
• Baumann CA, Ribon V, Kanzaki M, et al. (2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport" (PDF). Nature. 407 (6801): 202–7. Bibcode:2000Natur.407..202B. doi:10.1038/35025089. hdl: 2027.42/62940 . PMID   11001060. S2CID   4334519.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Salzer U, Prohaska R (2001). "Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts". Blood. 97 (4): 1141–3. doi:10.1182/blood.V97.4.1141. PMID   11159550.
• Edgar AJ, Polak JM (2001). "Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals". Int. J. Biochem. Cell Biol. 33 (1): 53–64. doi:10.1016/S1357-2725(00)00069-8. PMID   11167132.
• Kimura A, Baumann CA, Chiang SH, Saltiel AR (2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. Bibcode:2001PNAS...98.9098K. doi: 10.1073/pnas.151252898 . PMC   55379 . PMID   11481476.
• Stuermer CA, Lang DM, Kirsch F, et al. (2002). "Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2". Mol. Biol. Cell. 12 (10): 3031–45. doi:10.1091/mbc.12.10.3031. PMC   60153 . PMID   11598189.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Girardot N, Allinquant B, Duyckaerts C (2004). "[Lipid rafts, flotillin-1 and Alzheimer disease]". J. Soc. Biol. 197 (3): 223–9. doi:10.1051/jbio/2003197030223. PMID   14708344. S2CID   86221484.
• Wakasugi K, Nakano T, Kitatsuji C, Morishima I (2004). "Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein". Biochem. Biophys. Res. Commun. 318 (2): 453–60. doi:10.1016/j.bbrc.2004.04.045. PMID   15120622.
• Haglund K, Ivankovic-Dikic I, Shimokawa N, et al. (2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell Sci. 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. PMID   15128873. S2CID   14083271.
• Bared SM, Buechler C, Boettcher A, et al. (2005). "Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells". Mol. Biol. Cell. 15 (12): 5399–407. doi:10.1091/mbc.E04-03-0182. PMC   532019 . PMID   15469992.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Jacobowitz DM, Kallarakal AT (2005). "Flotillin-1 in the substantia nigra of the Parkinson brain and a predominant localization in catecholaminergic nerves in the rat brain". Neurotoxicity Research. 6 (4): 245–57. doi:10.1007/BF03033435. PMID   15545008. S2CID   22168131.
• Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID   15862967. S2CID   9746088.
• Glebov OO, Bright NA, Nichols BJ (2006). "Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells". Nat. Cell Biol. 8 (1): 46–54. doi:10.1038/ncb1342. PMID   16341206. S2CID   36695735.

External links

• FLOT1 human gene location in the UCSC Genome Browser .
• FLOT1 human gene details in the UCSC Genome Browser .