FLRT1

FLRT1
Identifiers
Aliases	FLRT1 , SPG68, fibronectin leucine rich transmembrane protein 1
External IDs	OMIM: 604806 MGI: 3026647 HomoloGene: 40864 GeneCards: FLRT1
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q13.1 Start 64,035,931 bp [1] End 64,119,173 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 A Start 7,069,366 bp [2] End 7,083,094 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 frontal pole ventral tegmental area inferior ganglion of vagus nerve cerebellar vermis globus pallidus internal globus pallidus subthalamic nucleus middle frontal gyrus renal medulla Top expressed in olfactory epithelium olfactory tubercle medial dorsal nucleus otolith organ utricle cingulate gyrus primary motor cortex kidney globus pallidus nucleus accumbens More reference expression data BioGPS n/a
Gene ontology Molecular function protein-macromolecule adaptor activity fibroblast growth factor receptor binding protein kinase inhibitor activity Cellular component cytoplasm integral component of membrane cell projection endoplasmic reticulum membrane membrane cell-cell junction focal adhesion integral component of plasma membrane neuronal cell body membrane extracellular region cell junction endoplasmic reticulum perinuclear region of cytoplasm neuron projection terminus cytoplasmic vesicle membrane cytoplasmic vesicle plasma membrane extracellular space extracellular matrix Biological process negative regulation of protein kinase activity cytokine-mediated signaling pathway dendrite development neuron projection extension multicellular organism development cell adhesion negative regulation of receptor signaling pathway via JAK-STAT positive regulation of synapse assembly fibroblast growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23769 396184 Ensembl ENSG00000126500 ENSMUSG00000047787 UniProt Q9NZU1 Q6RKD8 RefSeq (mRNA) NM_013280 NM_001384466 NM_201411 RefSeq (protein) NP_037412 NP_958813 Location (UCSC) Chr 11: 64.04 – 64.12 Mb Chr 19: 7.07 – 7.08 Mb PubMed search [3] [4]
Wikidata
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Fibronectin leucine rich transmembrane protein 1 is a protein that in humans is encoded by the FLRT1 gene. ^[5]

Function

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in the kidney and brain.

References

1. GRCh38: Ensembl release 89: ENSG00000126500 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047787 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Fibronectin leucine rich transmembrane protein 1" . Retrieved 2017-05-30.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.