FLRT2

FLRT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4V2C, 4V2D
Identifiers
Aliases	FLRT2 , fibronectin leucine rich transmembrane protein 2
External IDs	OMIM: 604807 MGI: 3603594 HomoloGene: 8291 GeneCards: FLRT2
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q31.3 Start 85,530,144 bp [1] End 85,654,428 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 E Start 95,659,000 bp [2] End 95,751,989 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium parietal pleura middle temporal gyrus retinal pigment epithelium spinal ganglia Brodmann area 23 trigeminal ganglion body of pancreas tibia stromal cell of endometrium Top expressed in ciliary body retinal pigment epithelium sciatic nerve vas deferens hand conjunctival fornix iris renal corpuscle medullary collecting duct trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-macromolecule adaptor activity fibroblast growth factor receptor binding protein kinase inhibitor activity chemorepellent activity Cellular component cytoplasm organelle membrane integral component of membrane endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle cell-cell junction focal adhesion synapse integral component of plasma membrane extracellular region cell junction endoplasmic reticulum neuron projection extracellular exosome plasma membrane extracellular space extracellular matrix Biological process negative chemotaxis negative regulation of protein kinase activity cytokine-mediated signaling pathway cell adhesion involved in heart morphogenesis heart morphogenesis axon guidance multicellular organism development cell adhesion basement membrane organization regulation of neuron migration negative regulation of receptor signaling pathway via JAK-STAT positive regulation of synapse assembly fibroblast growth factor receptor signaling pathway biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23768 399558 Ensembl ENSG00000185070 ENSMUSG00000047414 UniProt O43155 Q8BLU0 RefSeq (mRNA) NM_001346143 NM_001346144 NM_001346145 NM_001346146 NM_013231 NM_201518 RefSeq (protein) NP_001333072 NP_001333073 NP_001333074 NP_001333075 NP_037363 NP_958926 Location (UCSC) Chr 14: 85.53 – 85.65 Mb Chr 12: 95.66 – 95.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Fibronectin leucine-rich repeat transmembrane protein FLRT2 is a protein that in humans is encoded by the FLRT2 gene. ^{[5] [6] [7]}

Function

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRT family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000185070 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047414 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lacy SE, Bönnemann CG, Buzney EA, Kunkel LM (December 1999). "Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins". Genomics. 62 (3): 417–26. doi:10.1006/geno.1999.6033. PMID   10644439.
6. Haines BP, Wheldon LM, Summerbell D, Heath JK, Rigby PW (September 2006). "Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development". Developmental Biology. 297 (1): 14–25. doi:10.1016/j.ydbio.2006.04.004. PMID   16872596.
7. "Entrez Gene: FLRT2 fibronectin leucine rich transmembrane protein 2".

Further reading

• Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 4 (5): 307–13. doi: 10.1093/dnares/4.5.307 . PMID   9455477.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.