FMNL3

FMNL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4EAH
Identifiers
Aliases	FMNL3 , FHOD3, WBP-3, WBP3, FRL2, formin like 3
External IDs	OMIM: 616288; MGI: 109569; HomoloGene: 69101; GeneCards: FMNL3; OMA:FMNL3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.12 Start 49,636,499 bp [1] End 49,708,165 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 F1 Start 99,215,106 bp [2] End 99,268,363 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve appendix right coronary artery stromal cell of endometrium lymph node Achilles tendon apex of heart granulocyte left coronary artery right lung Top expressed in primary oocyte granulocyte calvaria internal carotid artery external carotid artery secondary oocyte zygote endocardial cushion semi-lunar valve ankle More reference expression data BioGPS n/a
Gene ontology Molecular function GTPase activating protein binding actin binding Cellular component cytoplasm membrane Golgi apparatus cytosol plasma membrane intracellular membrane-bounded organelle Biological process multicellular organism development actin cytoskeleton organization angiogenesis cellular component organization cytoskeleton organization regulation of cell shape cell migration cortical actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 91010 22379 Ensembl ENSG00000161791 ENSMUSG00000023008 UniProt Q8IVF7 Q6ZPF4 RefSeq (mRNA) NM_175736 NM_198900 NM_001367835 NM_011711 NM_001310622 NM_001310623 RefSeq (protein) NP_783863 NP_944489 NP_001354764 NP_001297551 NP_001297552 NP_035841 Location (UCSC) Chr 12: 49.64 – 49.71 Mb Chr 15: 99.22 – 99.27 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Formin-like protein 3 (FMNL3), also known as WW domain-binding protein 3 (WBP-3), is a protein that in humans is encoded by the FMNL3 gene. ^{[5] [6]}

Function

The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. ^[5] The C-terminus has been shown to accelerate actin polymerization activity of this protein through its WH2-like motif. ^[7] FMNL3 has been crystallized in complex with actin providing insight into the mechanism of formin-mediated actin nucleation. ^[8]

See also

• FMNL1
• FMNL2

References

1. GRCh38: Ensembl release 89: ENSG00000161791 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023008 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: formin-like 3".
6. Katoh M, Katoh M (May 2003). "Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico". International Journal of Oncology. 22 (5): 1161–8. doi:10.3892/ijo.22.5.1161. PMID   12684686.
7. Heimsath EG, Higgs HN (Jan 2012). "The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends". The Journal of Biological Chemistry. 287 (5): 3087–98. doi: 10.1074/jbc.M111.312207 . PMC   3270965 . PMID   22094460.
8. Thompson ME, Heimsath EG, Gauvin TJ, Higgs HN, Kull FJ (Jan 2013). "FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation". Nature Structural & Molecular Biology. 20 (1): 111–8. doi:10.1038/nsmb.2462. PMC   3876896 . PMID   23222643.

Further reading

• Bedford MT, Chan DC, Leder P (May 1997). "FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands". The EMBO Journal. 16 (9): 2376–83. doi:10.1093/emboj/16.9.2376. PMC   1169838 . PMID   9171351.