FMNL1

FMNL1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4YDH
Identifiers
Aliases	FMNL1 , C17orf1, C17orf1B, FHOD4, FMNL, KW-13, formin like 1
External IDs	OMIM: 604656 HomoloGene: 136798 GeneCards: FMNL1
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.31 Start 45,221,444 bp [1] End 45,247,319 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood spleen right lung upper lobe of left lung lymph node bone marrow cells appendix gallbladder prefrontal cortex n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function profilin binding GTPase activating protein binding actin filament binding protein binding actin binding molecular function Cellular component cytoplasm cell projection membrane plasma membrane cell cortex phagocytic vesicle bleb extracellular exosome cytoplasmic vesicle cytosol integral component of membrane Biological process actin filament severing substrate-dependent cell migration cytoskeleton organization regulation of cell shape cellular component organization cortical actin cytoskeleton organization actin cytoskeleton organization cellular process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 752 n/a Ensembl ENSG00000184922 n/a UniProt O95466 n/a RefSeq (mRNA) NM_005892 n/a RefSeq (protein) NP_005883 n/a Location (UCSC) Chr 17: 45.22 – 45.25 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Formin-like protein 1 is a protein that in humans is encoded by the FMNL1 gene. ^{[3] [4]}

This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined. ^[4]

Interactions

FMNL1 has been shown to interact with Profilin 1, ^[5] PFN2 ^[5] and RAC1. ^[5]

See also

• FMNL2
• FMNL3

References

1. GRCh38: Ensembl release 89: ENSG00000184922 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Aronsson FC, Magnusson P, Andersson B, Karsten SL, Shibasaki Y, Lendon CL, Goate AM, Brookes AJ (November 1998). "The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17". Hum Genet. 103 (3): 340–345. doi:10.1007/s004390050827. PMID   9799091. S2CID   11305597.
4. "Entrez Gene: FMNL1 formin-like 1".
5. Yayoshi-Yamamoto, S; Taniuchi I; Watanabe T (September 2000). "FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages". Mol. Cell. Biol. UNITED STATES. 20 (18): 6872–6881. doi:10.1128/MCB.20.18.6872-6881.2000. ISSN   0270-7306. PMC   86228 . PMID   10958683.

Further reading

• Kennerson ML, Nassif NT, Nicholson GA (1998). "Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat". Genomics. 53 (1): 110–112. doi:10.1006/geno.1998.5453. PMID   9787083.
• Yayoshi-Yamamoto S, Taniuchi I, Watanabe T (2000). "FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages". Mol. Cell. Biol. 20 (18): 6872–6881. doi:10.1128/MCB.20.18.6872-6881.2000. PMC   86228 . PMID   10958683.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Katoh M, Katoh M (2003). "Identification and characterization of human DAAM2 gene in silico". Int. J. Oncol. 22 (4): 915–20. doi:10.3892/ijo.22.4.915. PMID   12632087.
• Katoh M, Katoh M (2003). "Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico". Int. J. Oncol. 22 (5): 1161–8. doi:10.3892/ijo.22.5.1161. PMID   12684686.
• Favaro PM, de Souza Medina S, Traina F, et al. (2004). "Human leukocyte formin: a novel protein expressed in lymphoid malignancies and associated with Akt". Biochem. Biophys. Res. Commun. 311 (2): 365–371. doi:10.1016/j.bbrc.2003.10.012. PMID   14592423.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–1332. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.