FMNL1

Last updated
FMNL1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FMNL1 , C17orf1, C17orf1B, FHOD4, FMNL, KW-13, formin like 1
External IDs OMIM: 604656; MGI: 1888994; HomoloGene: 136798; GeneCards: FMNL1; OMA:FMNL1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005892

NM_001077698
NM_019679

RefSeq (protein)

NP_005883

Location (UCSC) Chr 17: 45.22 – 45.25 Mb Chr 11: 103.06 – 103.09 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Formin-like protein 1 is a protein that in humans is encoded by the FMNL1 gene. [5] [6]

This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined. [6]

Interactions

FMNL1 has been shown to interact with Profilin 1, [7] PFN2 [7] and RAC1. [7]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000184922 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055805 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Aronsson FC, Magnusson P, Andersson B, Karsten SL, Shibasaki Y, Lendon CL, Goate AM, Brookes AJ (November 1998). "The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17". Hum Genet. 103 (3): 340–345. doi:10.1007/s004390050827. PMID   9799091. S2CID   11305597.
  6. 1 2 "Entrez Gene: FMNL1 formin-like 1".
  7. 1 2 3 Yayoshi-Yamamoto, S; Taniuchi I; Watanabe T (September 2000). "FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages". Mol. Cell. Biol. 20 (18). UNITED STATES: 6872–6881. doi:10.1128/MCB.20.18.6872-6881.2000. ISSN   0270-7306. PMC   86228 . PMID   10958683.

Further reading