FRMPD4

FRMPD4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4WND, 4WNE, 4WNF, 4WNG
Identifiers
Aliases	FRMPD4 , PDZD10, PDZK10, FERM and PDZ domain containing 4, MRX104
External IDs	OMIM: 300838 MGI: 3042378 HomoloGene: 45843 GeneCards: FRMPD4
Gene location (Human)
Chr.	X chromosome (human)
End	12,724,523 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	167,360,227 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; endothelial cell; ; Brodmann area 23; ; Brodmann area 46; ; orbitofrontal cortex; ; superior frontal gyrus; ; postcentral gyrus; ; entorhinal cortex; ; prefrontal cortex; ; Region I of hippocampus proper;
	Top expressed in
	hippocampus proper; ; superior frontal gyrus; ; cerebellum; ; cerebellar cortex; ; vasculature; ; olfactory bulb; ; spinal ganglia; ; hypothalamus; ; secondary oocyte; ; choroid plexus;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatidylinositol-4,5-bisphosphate binding ; protein binding ; lipid binding ;
Cellular component	dendritic spine ; cell projection ; cytoskeleton ; protein-containing complex ; postsynaptic density ; glutamatergic synapse ;
Biological process	positive regulation of synapse structural plasticity ; postsynaptic actin cytoskeleton organization ;
	Sources:Amigo / QuickGO
Orthologs
	9758
	333605
	ENSG00000169933
	ENSMUSG00000049176
	Q14CM0
	A2AFR3
	NM_014728
NM_001033330 ; NM_001290427 ; NM_001290428 ; NM_001359072 ; NM_001368936 ;
	NM_001369234
NP_055543 ; NP_001355324 ; NP_001355325 ; NP_001355326 ; NP_001355327 ;
	NP_001355328 ; NP_001355329 ; NP_001355330 ; NP_001355331 Contents Function ; References ; Further reading ;
NP_001028502 ; NP_001277356 ; NP_001277357 ; NP_001346001 ; NP_001355865 ;
	NP_001356163
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 05, 2023

FERM and PDZ domain containing 4 is a protein that in humans is encoded by the FRMPD4 gene. ^[5]

Function

This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission.

Related Research Articles

Disks large homolog 2 (DLG2) also known as channel-associated protein of synapse-110 (chapsyn-110) or postsynaptic density protein 93 (PSD-93) is a protein that in humans is encoded by the DLG2 gene.

Frizzled-2(Fz-2) is a protein that in humans is encoded by the FZD2 gene.

Frizzled-1(Fz-1) is a protein that in humans is encoded by the FZD1 gene.

Frizzled-7(Fd-7) is a protein that in humans is encoded by the FZD7 gene.

Potassium voltage-gated channel subfamily A member 4 also known as K_v1.4 is a protein that in humans is encoded by the KCNA4 gene. It contributes to the cardiac transient outward potassium current (I_to1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.

SH3 and multiple ankyrin repeat domains protein 2 is a protein that in humans is encoded by the SHANK2 gene. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.

Ephrin-B3 is a protein that in humans is encoded by the EFNB3 gene.

ATP-sensitive inward rectifier potassium channel 10 is a protein that in humans is encoded by the KCNJ10 gene.

Calcium channel, voltage-dependent, gamma subunit 2, also known as CACNG2 or stargazin is a protein that in humans is encoded by the CACNG2 gene.

Disks large-associated protein 1 (DAP-1), also known as guanylate kinase-associated protein (GKAP), is a protein that in humans is encoded by the DLGAP1 gene. DAP-1 is known to be highly enriched in synaptosomal preparations of the brain, and present in the post-synaptic density.

Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.

Disks large-associated protein 2 is a protein that in humans is encoded by the DLGAP2 gene.

PDZ domain-containing protein 2 is a protein that in humans is encoded by the PDZD2 gene.

Cysteine-rich PDZ-binding protein is a protein that in humans is encoded by the CRIPT gene.

SH3 and multiple ankyrin repeat domains 3 (Shank3), also known as proline-rich synapse-associated protein 2 (ProSAP2), is a protein that in humans is encoded by the SHANK3 gene on chromosome 22. Additional isoforms have been described for this gene but they have not yet been experimentally verified.

FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene.

Connector enhancer of kinase suppressor of ras 2, also known as CNK homolog protein 2 (CNK2) or MAGUIN, is an enzyme that in humans is encoded by the CNKSR2 gene.

Sodium/hydrogen exchanger 6 is an integral membrane protein that in humans is encoded by the SLC9A6 gene. It was originally thought to be a mitochondrial-targeted protein, but subsequent studies have localized it to the plasma membrane and recycling endosomes.

FERM domain containing 4B is a protein that in humans is encoded by the FRMD4B gene.

FERM and PDZ domain containing 2 is a protein that in humans is encoded by the FRMPD2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000169933 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049176 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: FERM and PDZ domain containing 4" . Retrieved 2016-10-01.

Lee HW, Choi J, Shin H, Kim K, Yang J, Na M, Choi SY, Kang GB, Eom SH, Kim H, Kim E (2008). "Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis". J. Neurosci. 28 (53): 14546–56. doi:10.1523/JNEUROSCI.3112-08.2008. PMC 6671232 . PMID 19118189.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832 . PMID 19913121.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168 . PMID 20628086.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000169933 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049176 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FERM and PDZ domain containing 4" . Retrieved 2016-10-01.

[1]

[2]

[3]

[4]

[5]

FRMPD4

Contents

Function

Related Research Articles

References

Further reading