FSTL3

FSTL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KCX, 3B4V, 3SEK
Identifiers
Aliases	FSTL3 , FLRG, FSRP, follistatin like 3
External IDs	OMIM: 605343; MGI: 1890391; HomoloGene: 4280; GeneCards: FSTL3; OMA:FSTL3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.3 Start 676,392 bp [1] End 683,392 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 C1 Start 79,613,106 bp [2] End 79,618,464 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery tibial nerve ascending aorta left coronary artery apex of heart left adrenal cortex left uterine tube upper lobe of left lung gastric mucosa right adrenal gland Top expressed in ascending aorta aortic valve tunica media of zone of aorta umbilical cord morula lip decidua efferent ductule right lung lobe stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function fibronectin binding activin binding protein binding Cellular component Golgi apparatus secretory granule nucleoplasm extracellular region neuron projection terminus nucleus extracellular space endoplasmic reticulum lumen Biological process male gonad development regulation of transcription, DNA-templated negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway ossification negative regulation of osteoclast differentiation positive regulation of cell-cell adhesion kidney development lung development regulation of transcription by RNA polymerase II adrenal gland development transcription, DNA-templated negative regulation of BMP signaling pathway negative regulation of activin receptor signaling pathway cellular response to metal ion hematopoietic progenitor cell differentiation spermatogenesis positive regulation of transcription by RNA polymerase II post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10272 83554 Ensembl ENSG00000070404 ENSMUSG00000020325 UniProt O95633 Q9EQC7 RefSeq (mRNA) NM_005860 NM_031380 RefSeq (protein) NP_005851 NP_113557 Location (UCSC) Chr 19: 0.68 – 0.68 Mb Chr 10: 79.61 – 79.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Follistatin-related protein 3 (also known as follistatin-like protein 3) is a protein that in humans is encoded by the FSTL3 gene. ^{[5] [6] [7]}

Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000070404 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020325 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hayette S, Gadoux M, Martel S, Bertrand S, Tigaud I, Magaud JP, Rimokh R (Aug 1998). "FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders". Oncogene. 16 (22): 2949–54. doi:10.1038/sj.onc.1201807. PMID   9671416. S2CID   10736135.
6. Glusman G, Kaur A, Hood L, Rowen L (Nov 2004). "An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution". BMC Evol Biol. 4 43. doi: 10.1186/1471-2148-4-43 . PMC   533870 . PMID   15527507.
7. "Entrez Gene: FSTL3 follistatin-like 3 (secreted glycoprotein)".

Further reading

• Maguer-Satta V, Rimokh R (2005). "FLRG, member of the follistatin family, a new player in hematopoiesis". Mol. Cell. Endocrinol. 225 (1–2): 109–18. doi:10.1016/j.mce.2004.07.009. PMID   15451575. S2CID   25430198.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Tortoriello DV, Sidis Y, Holtzman DA, et al. (2001). "Human follistatin-related protein: a structural homologue of follistatin with nuclear localization". Endocrinology. 142 (8): 3426–34. doi: 10.1210/endo.142.8.8319 . PMID   11459787.
• Bartholin L, Maguer-Satta V, Hayette S, et al. (2001). "FLRG, an activin-binding protein, is a new target of TGFbeta transcription activation through Smad proteins". Oncogene. 20 (39): 5409–19. doi:10.1038/sj.onc.1204720. PMID   11571638. S2CID   29503172.
• Bartholin L, Maguer-Satta V, Hayette S, et al. (2002). "Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function". Oncogene. 21 (14): 2227–35. doi:10.1038/sj.onc.1205294. PMID   11948405. S2CID   1065429.
• Hill JJ, Davies MV, Pearson AA, et al. (2002). "The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum". J. Biol. Chem. 277 (43): 40735–41. doi: 10.1074/jbc.M206379200 . PMID   12194980.
• Liu J, Vänttinen T, Hydén-Granskog C, Voutilainen R (2003). "Regulation of follistatin-related gene (FLRG) expression by protein kinase C and prostaglandin E(2) in cultured granulosa-luteal cells". Mol. Hum. Reprod. 8 (11): 992–7. doi:10.1093/molehr/8.11.992. PMID   12397211.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Maguer-Satta V, Bartholin L, Jeanpierre S, et al. (2003). "Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFbeta family". Exp. Cell Res. 282 (2): 110–20. doi:10.1016/S0014-4827(02)00013-7. PMID   12531697.
• Wang HQ, Takebayashi K, Tsuchida K, et al. (2003). "Follistatin-related gene (FLRG) expression in human endometrium: sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells". J. Clin. Endocrinol. Metab. 88 (9): 4432–9. doi: 10.1210/jc.2002-021758 . PMID   12970321.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Xia Y, Sidis Y, Schneyer A (2004). "Overexpression of follistatin-like 3 in gonads causes defects in gonadal development and function in transgenic mice". Mol. Endocrinol. 18 (4): 979–94. doi: 10.1210/me.2003-0364 . PMID   14739256.
• Florio P, Ciarmela P, Toti P, et al. (2004). "Human endometrium and decidua express follistatin-related gene (FLRG) mRNA and peptide". Mol. Cell. Endocrinol. 218 (1–2): 129–35. doi:10.1016/j.mce.2003.12.019. PMID   15130517. S2CID   42635058.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Saito S, Sidis Y, Mukherjee A, et al. (2006). "Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3". Endocrinology. 146 (12): 5052–62. doi: 10.1210/en.2005-0833 . PMID   16150905.
• Okamoto A, Endo H, Kalionis B, et al. (2006). "IGFBP1 and Follistatin-like 3 genes are significantly up-regulated in expression profiles of the IUGR placenta". Placenta. 27 (2–3): 317–21. doi:10.1016/j.placenta.2004.12.007. PMID   16338475.

External links

• FSTL3 human gene location in the UCSC Genome Browser .
• FSTL3 human gene details in the UCSC Genome Browser .