FXR2

Last updated
FXR2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FXR2 , FMR1L2, FXR2P, FMR1 autosomal homolog 2
External IDs OMIM: 605339; MGI: 1346074; HomoloGene: 21014; GeneCards: FXR2; OMA:FXR2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004860

NM_011814

RefSeq (protein)

NP_004851

NP_035944

Location (UCSC) Chr 17: 7.59 – 7.61 Mb Chr 11: 69.52 – 69.54 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Fragile X mental retardation syndrome-related protein 2 is a protein that in humans is encoded by the FXR2 gene. [5] [6] [7]

Contents

Function

The protein encoded by this gene is an RNA-binding protein containing two KH domains and one RCG box, similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This protein may self-associate or interact with FMRP and FXR1. It may play a role in the development of fragile X mental retardation syndrome. [7]

Interactions

FXR2 has been shown to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000129245 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018765 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 3 Zhang Y, O'Connor JP, Siomi MC, Srinivasan S, Dutra A, Nussbaum RL, Dreyfuss G (Nov 1995). "The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2". The EMBO Journal. 14 (21): 5358–66. doi:10.1002/j.1460-2075.1995.tb00220.x. PMC   394645 . PMID   7489725.
  6. Tamanini F, Willemsen R, van Unen L, Bontekoe C, Galjaard H, Oostra BA, Hoogeveen AT (Aug 1997). "Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis". Human Molecular Genetics. 6 (8): 1315–22. doi: 10.1093/hmg/6.8.1315 . hdl: 1765/8709 . PMID   9259278.
  7. 1 2 "Entrez Gene: FXR2 fragile X mental retardation, autosomal homolog 2".
  8. Schenck A, Bardoni B, Moro A, Bagni C, Mandel JL (Jul 2001). "A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P". Proceedings of the National Academy of Sciences of the United States of America. 98 (15): 8844–9. Bibcode:2001PNAS...98.8844S. doi: 10.1073/pnas.151231598 . PMC   37523 . PMID   11438699.
  9. 1 2 Siomi MC, Zhang Y, Siomi H, Dreyfuss G (Jul 1996). "Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them". Molecular and Cellular Biology. 16 (7): 3825–32. doi:10.1128/mcb.16.7.3825. PMC   231379 . PMID   8668200.
  10. Ceman S, Brown V, Warren ST (Dec 1999). "Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex". Molecular and Cellular Biology. 19 (12): 7925–32. doi:10.1128/mcb.19.12.7925. PMC   84877 . PMID   10567518.
  11. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

Further reading