Flavonifractor plautii

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Flavonifractor plautii
Flavonifractor plautii.png
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Bacteria
Kingdom: Bacillati
Phylum: Bacillota
Class: Clostridia
Order: Oscillospirales
Family: Oscillospiraceae
Genus: Flavonifractor
Species:
F. plautii
Binomial name
Flavonifractor plautii
(Séguin 1928) Carlier et al. 2010 [1]
Synonyms
  • Clostridium orbiscindensWinter et al. 1991
  • Eubacterium plautii(Séguin 1928) Hofstad and Aasjord 1982
  • Fusobacterium plauti [1]
  • Fusobacterium plautiiSéguin 1928

Flavonifractor plautii is a bacterium of the monotypic genus Flavonifractor in the family Oscillospiraceae .

Contents

History

This species was originally placed in the genus Fusobacterium by S. Seguin in 1928, [2] and was later recategorized as Fusocillus in 1938 by A.R. Prevot. [3] This classification remained until 1962, when M. Sebald renamed the species Zuberella plauti. [4] In 1928, Skerman VBD and colleagues referred to this species as Fusobacterium plauti in the “Approved Lists of Bacterial Names”. [5] In 1982, Hofstad and Aasjord officially assigned the name Eubacterium plautii to this species. [6] In 1991, Winter et al. highlighted the bacterium’s ability to cleave flavonoids and introduced its basionym as Clostridium orbiscindens. [7] Finally, in 2010, Carlier et al. proposed the unification of Clostridium orbiscindens and Eubacterium plautii under the new name Flavonifractor plautii. The cells are described as straight or slightly curved rods, 2–10 microns long, occurring singly or in pairs. Strains have been isolated from human feces, blood, intra-abdominal pus, and infected soft tissues. [8]

Genome

Flavonifractor plautii has a genome consisting of a single circular chromosome with 3,985,392 base pairs, with a G+C content of 60.9%. The genome is predicted to contain 3 complete sets of rRNA genes, 63 tRNA genes, and 3,764 protein-coding sequences. [9]

Metabolism and ecology

This bacterium is an obligate anaerobe that is capable of cleaving the C-ring found in flavonoids. Flavonifractor plautii is highly prevalent in the human gastrointestinal tract, and is known to be a proficient producer of butyrate. [10]

Clinical significance

Flavonifractor plautii was found to be associated with colorectal cancer (CRC) in a cohort of 30 CRC patients and 30 healthy controls. It was hypothesized that the degradation of beneficial anticarcinogenic flavonoids, such as quercetin, by F. plautii may contribute to the cancer. [11] Flavonifractor plautii was also found to be significantly enriched in major depressive disorder (MDD) in a cohort of 90 American young adults (43 with MDD, 47 healthy).

In pediatric inflammatory bowel disease, F. plautii was shown to preferentially bind immunoglobulin G (IgG) from Crohn’s disease patients compared to non-inflammatory bowel disease and ulcerative colitis samples. It also demonstrated invasive potential in vitro using a fluorescence microscopy assay with intestinal epithelial cells in culture. [12]

References

  1. 1 2 Page Species: Flavonifractor plautii on "LPSN - List of Prokaryotic names with Standing in Nomenclature". Deutsche Sammlung von Mikroorganismen und Zellkulturen . Retrieved 2022-10-03.
  2. ↑ du Bois P (May 2003). "Sur la forme de Seifert entière des germes de courbe plane à deux branches". Comptes Rendus Mathematique. 336 (9): 757–762. doi:10.1016/s1631-073x(03)00165-1. ISSN   1631-073X.
  3. ↑ Williams P (2017). "Le Pasteur Matéo". Études Tsiganes. 60 (1): 142. doi:10.3917/tsig.060.0142. ISSN   0014-2247.
  4. ↑ Pichinoty F (October 1962). "Inhibition par l'oxygene de la biosynthese et de l'activitee de l'hydrogenase et de l'hydrogenelyase chez les bacteries anaerobies facultatives". Biochimica et Biophysica Acta. 64 (1): 111–124. doi:10.1016/0006-3002(62)90764-3. ISSN   0006-3002. PMID   13943284.
  5. ↑ Skerman VB, Sneath PH, McGowan V (1980-01-01). "Approved Lists of Bacterial Names". International Journal of Systematic and Evolutionary Microbiology. 30 (1): 225–420. doi: 10.1099/00207713-30-1-225 . ISSN   1466-5026.
  6. ↑ Hofstad T, Aasjor P (1982-07-01). "Eubacterium plautii (Seguin 1928) comb. nov". International Journal of Systematic Bacteriology. 32 (3): 346–349. doi: 10.1099/00207713-32-3-346 . ISSN   0020-7713.
  7. ↑ Winter J, Popoff MR, Grimont P, Bokkenheuser VD (1991-07-01). "Clostridium orbiscindens sp. nov., a Human Intestinal Bacterium Capable of Cleaving the Flavonoid C-Ring". International Journal of Systematic Bacteriology. 41 (3): 355–357. doi: 10.1099/00207713-41-3-355 . ISSN   0020-7713. PMID   1883711.
  8. ↑ Carlier JP, Bedora-Faure M, K'ouas G, Alauzet C, Mory F (2010-03-01). "Proposal to unify Clostridium orbiscindens Winter et al. 1991 and Eubacterium plautii (Séguin 1928) Hofstad and Aasjord 1982, with description of Flavonifractor plautii gen. nov., comb. nov., and reassignment of Bacteroides capillosus to Pseudoflavonifractor capillosus gen. nov., comb. nov". International Journal of Systematic and Evolutionary Microbiology. 60 (Pt 3): 585–590. doi: 10.1099/ijs.0.016725-0 . ISSN   1466-5026. PMID   19654357.
  9. ↑ Tourlousse DM, Sakamoto M, Miura T, Narita K, Ohashi A, Uchino Y, et al. (2020-04-23). Rasko D (ed.). "Complete Genome Sequence of Flavonifractor plautii JCM 32125 T". Microbiology Resource Announcements. 9 (17): e00135–20. doi:10.1128/MRA.00135-20. ISSN   2576-098X. PMC   7180276 . PMID   32327522. S2CID   216110981.
  10. ↑ Rajilić-Stojanović M, de Vos WM (September 2014). "The first 1000 cultured species of the human gastrointestinal microbiota". FEMS Microbiology Reviews. 38 (5): 996–1047. doi:10.1111/1574-6976.12075. ISSN   1574-6976. PMC   4262072 . PMID   24861948.
  11. ↑ Gupta A, Dhakan DB, Maji A, Saxena R, PK VP, Mahajan S, et al. (2019-12-17). Bordenstein S (ed.). "Association of Flavonifractor plautii, a Flavonoid-Degrading Bacterium, with the Gut Microbiome of Colorectal Cancer Patients in India". mSystems. 4 (6): e00438–19. doi:10.1128/mSystems.00438-19. ISSN   2379-5077. PMC   7407896 . PMID   31719139.
  12. ↑ Armstrong H, Alipour M, Valcheva R, Bording-Jorgensen M, Jovel J, Zaidi D, et al. (December 2019). "Host immunoglobulin G selectively identifies pathobionts in pediatric inflammatory bowel diseases". Microbiome. 7 (1) 1. doi: 10.1186/s40168-018-0604-3 . ISSN   2049-2618. PMC   6317230 . PMID   30606251.


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