Ford Doolittle | |
---|---|
Born | W. Ford Doolittle February 21, 1942 Urbana, Illinois, U.S. |
Education | Harvard University (BA 1963), Stanford University (PhD 1967), NSCAD University, Nova Scotia (BA in photography) |
Known for | Horizontal gene transfer in prokaryotic evolution |
Awards | National Academy of Sciences, Royal Society of Canada |
Scientific career | |
Fields | Cyanobacteria, chloroplasts |
Institutions | Dalhousie University |
Doctoral advisor | Charles Yanofsky |
W. Ford Doolittle FRSC FRS (born February 21, 1942, in Urbana, Illinois) [1] is an evolutionary and molecular biologist. He is a member of the US National Academy of Sciences a Fellow of the [[Royal Society of Canada], a Fellow of the Royal Society (UK] and of the Norwegian Academy of Science and Letters. [2] He is also the winner of the 2013 Herzberg Medal of the Natural Sciences and Engineering Research Council of Canada [3] and the 2017 Killam Prize. [4]
Doolittle has made significant contributions to the study of cyanobacteria. He found evidence for the endosymbiont origins of chloroplasts, and developed a theoretical basis for the initial evolution of eukaryotes. He has shown the importance of horizontal gene transfer in prokaryotic evolution.
As of 2007 [update] , he has been professor emeritus at Dalhousie University in Halifax, Nova Scotia. [5] He received his BA in biochemical sciences from Harvard University in 1963 and his PhD from Stanford University in 1967, under Charles Yanofsky. He went on to do postdoctoral fellowships with Sol Spiegelman and Norman R. Pace.
In 1981, Doolittle received some level of notoriety for his article in The CoEvolution Quarterly entitled "Is Nature Really Motherly?". This was a sharp rebuttal of J. E. Lovelock's formulation of the Gaia Theory. Doolittle's article is often cited by Lovelock's critics. He has had a re-think about Gaia, publishing an open access book, Darwinizing Gaia, in 2024, with MIT Press.
Because of his philosophical musings on the non-existence of an all-encompassing Tree of life, Doolittle has occasionally been cited on Intelligent Design blogs. However, though Doolittle argues that a bifurcating tree is not an adequate metaphor for the evolution of life on earth, he is not a supporter of Intelligent Design. A single common ancestor and tree relating all of life on earth is not a necessary component of the theory of descent with modification, the essence of evolution.
Doolittle is currently involved in a debate about the proper use of function (biology) within evolutionary biology sparked by controversy over the results of the ENCODE consortium stating that 80% of the genome is "functional". [6] He is a supporter of the concept of junk DNA.
In addition to his contributions to evolutionary biology, Doolittle is an artist who studied at NSCAD University, achieving a BA in photography.
Euglenozoa are a large group of flagellate Discoba. They include a variety of common free-living species, as well as a few important parasites, some of which infect humans. Euglenozoa are represented by four major groups, i.e., Kinetoplastea, Diplonemea, Euglenida, and Symbiontida. Euglenozoa are unicellular, mostly around 15–40 μm (0.00059–0.00157 in) in size, although some euglenids get up to 500 μm (0.020 in) long.
Lynn Margulis was an American evolutionary biologist, and was the primary modern proponent for the significance of symbiosis in evolution. In particular, Margulis transformed and fundamentally framed current understanding of the evolution of cells with nuclei by proposing it to have been the result of symbiotic mergers of bacteria. Margulis was also the co-developer of the Gaia hypothesis with the British chemist James Lovelock, proposing that the Earth functions as a single self-regulating system, and was the principal defender and promulgator of the five kingdom classification of Robert Whittaker.
In biological taxonomy, a domain, also dominion, superkingdom, realm, or empire, is the highest taxonomic rank of all organisms taken together. It was introduced in the three-domain system of taxonomy devised by Carl Woese, Otto Kandler and Mark Wheelis in 1990.
The three-domain system is a taxonomic classification system that groups all cellular life into three domains, namely Archaea, Bacteria and Eukarya, introduced by Carl Woese, Otto Kandler and Mark Wheelis in 1990. The key difference from earlier classifications such as the two-empire system and the five-kingdom classification is the splitting of Archaea from Bacteria as completely different organisms.
Excavata is an extensive and diverse but paraphyletic group of unicellular Eukaryota. The group was first suggested by Simpson and Patterson in 1999 and the name latinized and assigned a rank by Thomas Cavalier-Smith in 2002. It contains a variety of free-living and symbiotic protists, and includes some important parasites of humans such as Giardia and Trichomonas. Excavates were formerly considered to be included in the now obsolete Protista kingdom. They were distinguished from other lineages based on electron-microscopic information about how the cells are arranged. They are considered to be a basal flagellate lineage.
The Gaia hypothesis, also known as the Gaia theory, Gaia paradigm, or the Gaia principle, proposes that living organisms interact with their inorganic surroundings on Earth to form a synergistic and self-regulating complex system that helps to maintain and perpetuate the conditions for life on the planet.
The opisthokonts are a broad group of eukaryotes, including both the animal and fungus kingdoms. The opisthokonts, previously called the "Fungi/Metazoa group", are generally recognized as a clade. Opisthokonts together with Apusomonadida and Breviata comprise the larger clade Obazoa.
Peter William Hochachka, was a Canadian professor and zoologist at the University of British Columbia (UBC). He is known for his foundational work in creating the new field of adaptational biochemistry, connecting metabolic biochemistry with comparative physiology.
The Archaeplastida are a major group of eukaryotes, comprising the photoautotrophic red algae (Rhodophyta), green algae, land plants, and the minor group glaucophytes. It also includes the non-photosynthetic lineage Rhodelphidia, a predatorial (eukaryotrophic) flagellate that is sister to the Rhodophyta, and probably the microscopic picozoans. The Archaeplastida have chloroplasts that are surrounded by two membranes, suggesting that they were acquired directly through a single endosymbiosis event by phagocytosis of a cyanobacterium. All other groups which have chloroplasts, besides the amoeboid genus Paulinella, have chloroplasts surrounded by three or four membranes, suggesting they were acquired secondarily from red or green algae. Unlike red and green algae, glaucophytes have never been involved in secondary endosymbiosis events.
The tree of life or universal tree of life is a metaphor, conceptual model, and research tool used to explore the evolution of life and describe the relationships between organisms, both living and extinct, as described in a famous passage in Charles Darwin's On the Origin of Species (1859).
The affinities of all the beings of the same class have sometimes been represented by a great tree. I believe this simile largely speaks the truth.
Johann Peter Gogarten is a German-American biologist studying the early evolution of life. Born in Bad Oeynhausen, Germany, he studied plant physiology and membrane transport with Friedrich-Wilhelm Bentrup in Tübingen and Giessen. In 1987 he moved to the US as a postdoc to work with Lincoln Taiz at UC Santa Cruz. He currently is Distinguished Professor of Molecular and Cell Biology at the University of Connecticut in Storrs, CT.
Horizontal gene transfer (HGT) refers to the transfer of genes between distant branches on the tree of life. In evolution, it can scramble the information needed to reconstruct the phylogeny of organisms, how they are related to one another.
The eukaryotes constitute the domain of Eukaryota or Eukarya, organisms whose cells have a membrane-bound nucleus. All animals, plants, fungi, seaweeds, and many unicellular organisms are eukaryotes. They constitute a major group of life forms alongside the two groups of prokaryotes: the Bacteria and the Archaea. Eukaryotes represent a small minority of the number of organisms, but given their generally much larger size, their collective global biomass is much larger than that of prokaryotes.
Brian Keith Hall is the George S. Campbell Professor of Biology and University Research Professor Emeritus at Dalhousie University in Halifax, Nova Scotia. Hall has researched and extensively written on bone and cartilage formation in developing vertebrate embryos. He is an active participant in the evolutionary developmental biology (EVO-DEVO) debate on the nature and mechanisms of animal body plan formation. Hall has proposed that the neural crest tissue of vertebrates may be viewed as a fourth embryonic germ layer. As such, the neural crest - in Hall's view - plays a role equivalent to that of the endoderm, mesoderm, and ectoderm of bilaterian development and is a definitive feature of vertebrates. As such, vertebrates are the only quadroblastic, rather than triploblastic bilaterian animals. In vertebrates the neural crest serves to integrate the somatic division and visceral division together via a wide range novel vertebrate tissues.
The eocyte hypothesis in evolutionary biology proposes that the eukaryotes originated from a group of prokaryotes called eocytes. After his team at the University of California, Los Angeles discovered eocytes in 1984, James A. Lake formulated the hypothesis as "eocyte tree" that proposed eukaryotes as part of archaea. Lake hypothesised the tree of life as having only two primary branches: prokaryotes, which include Bacteria and Archaea, and karyotes, that comprise Eukaryotes and eocytes. Parts of this early hypothesis were revived in a newer two-domain system of biological classification which named the primary domains as Archaea and Bacteria.
Jeffrey Alexander Hutchings FRSC was a Canadian fisheries scientist. He was a professor of biology, and the Izaak Walton Killam Memorial Chair in Fish, Fisheries, and Oceans at Dalhousie University.
Microbial phylogenetics is the study of the manner in which various groups of microorganisms are genetically related. This helps to trace their evolution. To study these relationships biologists rely on comparative genomics, as physiology and comparative anatomy are not possible methods.
Reticulate evolution, or network evolution is the origination of a lineage through the partial merging of two ancestor lineages, leading to relationships better described by a phylogenetic network than a bifurcating tree. Reticulate patterns can be found in the phylogenetic reconstructions of biodiversity lineages obtained by comparing the characteristics of organisms. Reticulation processes can potentially be convergent and divergent at the same time. Reticulate evolution indicates the lack of independence between two evolutionary lineages. Reticulation affects survival, fitness and speciation rates of species.
Andrew J. Roger is a Canadian-Australian molecular biologist and evolutionary bioinformatician. He is currently a professor in the Department of Biochemistry and Molecular Biology at Dalhousie University and was the founding director of the inter-departmental Centre for Comparative Genomics and Evolutionary Bioinformatics (CGEB).
The two-domain system is a biological classification by which all organisms in the tree of life are classified into two domains, Bacteria and Archaea. It emerged from development of knowledge of archaea diversity and challenges the widely accepted three-domain system that classifies life into Bacteria, Archaea, and Eukarya. It was preceded by the eocyte hypothesis of James A. Lake in the 1980s, which was largely superseded by the three-domain system, due to evidence at the time. Better understanding of archaea, especially of their roles in the origin of eukaryotes through symbiogenesis with bacteria, led to the revival of the eocyte hypothesis in the 2000s. The two-domain system became more widely accepted after the discovery of a large group (superphylum) of Archaea called Asgard in 2017, which evidence suggests to be the evolutionary root of eukaryotes, thereby making eukaryotes members of the domain Archaea.