Friedrich Miescher Institute for Biomedical Research

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Friedrich Miescher Institute for Biomedical Research
FMI building 1000 portrait.jpg
FMI building in Basel, Switzerland
Established1970
Research type Basic research (non-clinical)
Field of research
Director Dirk Schübeler
Location Basel, Switzerland
Affiliations University of Basel
Website www.fmi.ch

The Friedrich Miescher Institute for Biomedical Research (FMI) is a biomedical research institute founded in 1970. Based in Basel, Switzerland, the FMI is affiliated with the University of Basel and the Novartis Institutes for BioMedical Research (NIBR). It is named after Friedrich Miescher. As of 2021, the FMI has around 340 collaborators, of which 20 are research group leaders, over 80 are postdoctoral collaborators and over 80 are postgraduate students participating in the FMI International PhD Program. The FMI is directed by Dirk Schübeler.

Contents

The FMI is member of EU-LIFE, an alliance of leading life sciences research centres in Europe. [1]

Scientific activities

The FMI is devoted to the pursuit of fundamental biomedical research. Areas of research are neurobiology, genome regulation, and multicellular systems.

Research is carried out in 20 independent but highly interactive[ citation needed ] research groups. In addition, several cutting-edge technology platforms - including microscopy & imaging, computational biology, functional genomics, proteomics, structural biology and more - support the research activities. [ citation needed ]

From 2014 to 2019, the FMI had the highest success rate for ERC grant applications of all European institutions. [2]

Research highlights

Teaching and training

The FMI is an affiliated institute of the University of Basel. [14] It provides biomedical research and career training for its 80-100 PhD students at a time. FMI selects its highly international student body during a twice-yearly interview-based selection program. [15] Most FMI group leaders have adjunct or full professorships at the University of Basel in the Natural Sciences Faculty. In particular, the FMI participates actively in the teaching program of the Biozentrum of the University of Basel.

The FMI also offers training in biomedical research to postdoctoral fellows. It was designated by a survey of The Scientist in 2012, as the “best place for postdoctoral training” outside of the US. [16] [17]

Patents and translational implementation

A goal of the FMI is the patenting of its discoveries and implementation of its basic research into pharmaceutical development. [18]

History

The Friedrich Miescher Institute for Biomedical Research is named after the Basel scientist Friedrich Miescher who discovered nucleic acids in the mid-19th century.

The FMI was founded in 1970, a hundred years after Miescher's discovery, as a collaborative effort of two Basel-based pharmaceutical companies, Ciba Aktiengesellschaft and J. R. Geigy Ltd. [19] The founding charter describes the aims of the institute as to “pursue and promote basic research in the fields of biochemistry and medicine…“ and “…to provide young scientists from all over the world with an opportunity to participate in scientific research.” [20] The Founding Director was Professor Hubert Bloch (died 1974) who had been Director of Research at Ciba Aktiengesellschaft, and Professor of Microbiology and Immunology at the University of Basel. He was an expert in tuberculosis [21] [22] and was also instrumental in the founding of the Institut Suisse pour les Recherches Experimentales sur la Cancer (ISREC), Epalinges, Switzerland. Between 1997 and 2012, the FMI was part of the Novartis Research Foundation. [23] Since 2012 the FMI is an independent foundation. [24]

Directors

List of the successive directors of the Friedrich Miescher Institute for Biomedical Research:

Friedrich Miescher Award

The Friedrich Miescher Award is Switzerland's highest honor for up-and-coming biochemical researchers. The award is granted every year by the Swiss Society for Biochemistry [25] to the best scientific contribution in this field. Prize winners must be under 40 and must either be Swiss citizens or have conducted the prize-winning research in this country. The award was instituted in 1970, proposed and donated by the FMI. It is named after the Basel scientist who discovered DNA, Friedrich Miescher.

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Silvia Arber Swiss neurobiologist

Silvia Arber is a Swiss neurobiologist. She teaches and researches at both the Biozentrum of the University of Basel and the Friedrich Miescher Institute for Biomedical Research in Basel Switzerland.

Barbara HohnForMemRS is an Austrian molecular biologist, particularly known for her research into the Agrobacterium tumefaciens.

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Susan M. Gasser is a Swiss molecular biologist. She was the Director of the Friedrich Miescher Institute for Biomedical Research in Basel, Switzerland, from 2004 - 2019, where she also led a research group from 2004 until 2021. She was in parallel Professor of molecular biology at the University of Basel until April 2021. Since January 2021, Susan Gasser is Director of the ISREC Foundation, based in Lausanne, and is Professor invité at the University of Lausanne in the Department of Fundamental Microbiology. She is an expert in quantitative biology and studies epigenetic inheritance and genome stability.

Ruth Chiquet-Ehrismann was a Swiss biochemist and cell biologist working on interactions in the extracellular matrix.

Owen Witte is an American physician-scientist at the University of California, Los Angeles. He is a distinguished professor of microbiology, immunology and molecular genetics in the David Geffen School of Medicine at UCLA, founding director of the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and the UC Regents’ David Saxon Presidential Chair in developmental immunology (1989–present). Witte is also a Howard Hughes Medical Institute investigator (1986–present) and a member of the President's Cancer Panel. He also served on the Life Sciences jury for the Infosys Prize in 2013.

Jin Zhang is a Chinese-American biochemist. She is a professor of pharmacology, chemistry and biochemistry, and biomedical engineering at the University of California, San Diego.

Nadine Gogolla is a Research Group Leader at the Max Planck Institute of Neurobiology in Martinsried, Germany as well as an Associate Faculty of the Graduate School for Systemic Neuroscience. Gogolla investigates the neural circuits underlying emotion to understand how the brain integrates external cues, feeling states, and emotions to make calculated behavioral decisions. Gogolla is known for her discovery using machine learning and two-photon microscopy to classify mouse facial expressions into emotion-like categories and correlate these facial expressions with neural activity in the insular cortex.

Isabelle Mansuy Neuroscientist

Isabelle M. Mansuy is a professor in neuroepigenetics in the Medical Faculty of the University of Zurich and the Department of Health Science and Technology of the Swiss Federal Institute of Technology Zurich. She is known for her work on the mechanisms of epigenetic inheritance in relation to childhood trauma.

Dirk Schübeler German molecular biology researcher (born 1969)

Dirk Schübeler is a German researcher, Director of the Friedrich Miescher Institute for Biomedical Research (FMI) and professor at the University of Basel. He is an expert in gene regulation.

Collin Y. Ewald Swiss molecular biologist

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See also