GTPase activating protein and VPS9 domains 1, also known as GAPVD1, Gapex-5 and RME-6 is a protein which in humans is encoded by the GAPVD1 gene. [5] [6]
GTPase activating protein and VPS9 domains 1, also known as GAPVD1, Gapex-5 and RME-6 is a protein which in humans is encoded by the GAPVD1 gene. [5] [6]
GAPVD1 is Rab GTPase guanine nucleotide exchange factor essential for activation of RAB5A during engulfment of apoptotic cells. [7] GAPVD1 is also involved in the degradation of the epidermal growth factor receptor. [8] Gapex-5 mediated activation of Rab5 has been implicated in the insulin stimulated formation of plasma membrane phosphatidylinositol-3-phosphate. [9]
Based on sequence homology, mammalian Gapex-5 has been shown to have an amino-terminal Ras GAP domain, a central polyproline (SH3 binding) region and a carboxy-terminal Rab GEF domain. The RabGEF domain has been suggested to activate Rab5 [10] and Rab31. [11]
The G protein-coupled bile acid receptor 1 (GPBAR1) also known G-protein coupled receptor 19 (GPCR19), membrane-type receptor for bile acids (M-BAR) or Takeda G protein-coupled receptor 5 (TGR5) as is a protein that in humans is encoded by the GPBAR1 gene.
Receptor tyrosine-protein kinase erbB-3, also known as HER3, is a membrane bound protein that in humans is encoded by the ERBB3 gene.
RAS p21 protein activator 1 or RasGAP, also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal activities:
Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334.
Ras-related protein Rab-5A is a protein that in humans is encoded by the RAB5A gene.
Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene. TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
Cdc42-interacting protein 4 is a protein that in humans is encoded by the TRIP10 gene.
Rho-related GTP-binding protein RhoQ is a protein that in humans is encoded by the RHOQ gene.
Chimerin 2 (beta-chimaerin) is a protein that in humans is encoded by the CHN2 gene.
EH domain-containing protein 1, also known as testilin or PAST homolog 1 (PAST1), is a protein that in humans is encoded by the EHD1 gene belonging to the EHD protein family.
Ras-related protein Rab-5B is a protein that in humans is encoded by the RAB5B gene.
Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.
Rab5 GDP/GTP exchange factor is a protein that in humans is encoded by the RABGEF1 gene.
Ras and Rab interactor 1 is a protein that in humans is encoded by the RIN1 gene.
USP6 N-terminal-like protein is a protein that in humans is encoded by the USP6NL gene.
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ASAP2 gene.
TC10/CDC42 GTPase-activating protein is an enzyme that in humans is encoded by the SNX26 gene.
Ras-related protein Rab-34 is a protein that in humans is encoded by the RAB34 gene.
Ras-related protein Rab-5C is a protein that in humans is encoded by the RAB5C gene. RAB5C belongs to the Ras-related protein family.
Rabenosyn-5 is a protein that in humans is encoded by the ZFYVE20 gene.
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