RAB5A

Last updated
RAB5A
Protein RAB5A PDB 1huq.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RAB5A , RAB5, member RAS oncogene family
External IDs OMIM: 179512; MGI: 105926; HomoloGene: 68142; GeneCards: RAB5A; OMA:RAB5A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004162
NM_001292048

NM_025887

RefSeq (protein)

NP_001278977
NP_004153

NP_080163

Location (UCSC) Chr 3: 19.95 – 19.99 Mb Chr 17: 53.79 – 53.81 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras-related protein Rab-5A is a protein that in humans is encoded by the RAB5A gene. [5] [6]

Function

RAB5A localizes to early endosomes where it is involved in the recruitment of RAB7A and the maturation of these compartments to early endosomes. [7] It drives the maturation of endosomes by transporting vacuolar (H+)-ATPases (V-ATPases) from trans-Golgi network to endocytic vesicles. [8]

Interactions

RAB5A has been shown to interact with:

Related Research Articles

<span class="mw-page-title-main">Endosome</span> Vacuole to which materials ingested by endocytosis are delivered

Endosomes are a collection of intracellular sorting organelles in eukaryotic cells. They are parts of the endocytic membrane transport pathway originating from the trans Golgi network. Molecules or ligands internalized from the plasma membrane can follow this pathway all the way to lysosomes for degradation or can be recycled back to the cell membrane in the endocytic cycle. Molecules are also transported to endosomes from the trans Golgi network and either continue to lysosomes or recycle back to the Golgi apparatus.

The Rab family of proteins is a member of the Ras superfamily of small G proteins. Approximately 70 types of Rabs have now been identified in humans. Rab proteins generally possess a GTPase fold, which consists of a six-stranded beta sheet which is flanked by five alpha helices. Rab GTPases regulate many steps of membrane trafficking, including vesicle formation, vesicle movement along actin and tubulin networks, and membrane fusion. These processes make up the route through which cell surface proteins are trafficked from the Golgi to the plasma membrane and are recycled. Surface protein recycling returns proteins to the surface whose function involves carrying another protein or substance inside the cell, such as the transferrin receptor, or serves as a means of regulating the number of a certain type of protein molecules on the surface.

<span class="mw-page-title-main">RHOB</span> Protein-coding gene in the species Homo sapiens

Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene.

<span class="mw-page-title-main">RAB11A</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-11A is a protein that in humans is encoded by the RAB11A gene.

<span class="mw-page-title-main">RAB3A</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-3A is a protein that in humans is encoded by the RAB3A gene. It is involved in calcium-triggered exocytosis in neurons.

<span class="mw-page-title-main">RAB4A</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-4A is a protein that in humans is encoded by the RAB4A gene.

<span class="mw-page-title-main">RAB1A</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-1A is a protein that in humans is encoded by the RAB1A gene.

<span class="mw-page-title-main">STX12</span> Protein-coding gene in the species Homo sapiens

Syntaxin-12 is a protein that in humans is encoded by the STX12 gene.

<span class="mw-page-title-main">RAB5B</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-5B is a protein that in humans is encoded by the RAB5B gene.

<span class="mw-page-title-main">RABGEF1</span> Protein-coding gene in the species Homo sapiens

Rab5 GDP/GTP exchange factor is a protein that in humans is encoded by the RABGEF1 gene.

<span class="mw-page-title-main">RAB11FIP5</span> Protein-coding gene in the species Homo sapiens

Rab11 family-interacting protein 5 is a protein that in humans is encoded by the RAB11FIP5 gene.

<span class="mw-page-title-main">APPL1</span> Protein-coding gene in the species Homo sapiens

Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1), or DCC-interacting protein 13-alpha (DIP13alpha), is a protein that in humans is encoded by the APPL1 gene. APPL1 contains several key interactory domains: pleckstrin homology (PH) domain, phosphotyrosine-binding (PTB) domain and Bin–Amphiphysin–Rvs (BAR) domain.

<span class="mw-page-title-main">RABEP1</span> Protein-coding gene in the species Homo sapiens

Rab GTPase-binding effector protein 1 is an enzyme that in humans is encoded by the RABEP1 gene. It belongs to rabaptin protein family.

<span class="mw-page-title-main">USP6NL</span> Protein-coding gene in the species Homo sapiens

USP6 N-terminal-like protein is a protein that in humans is encoded by the USP6NL gene.

<span class="mw-page-title-main">RhoD</span> Protein-coding gene in the species Homo sapiens

RhoD is a small signaling G protein, and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RHOD.

<span class="mw-page-title-main">RAB11B</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-11B is a protein that in humans is encoded by the RAB11B gene. Rab11b is reported as most abundantly expressed in brain, heart and testes.

<span class="mw-page-title-main">RAB5C</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-5C is a protein that in humans is encoded by the RAB5C gene. RAB5C belongs to the Ras-related protein family.

<span class="mw-page-title-main">ZFYVE20</span> Protein-coding gene in the species Homo sapiens

Rabenosyn-5 is a protein that in humans is encoded by the ZFYVE20 gene.

<span class="mw-page-title-main">Rabaptin</span>

Rabaptin is a key protein involved in regeneration of injured axons.

<span class="mw-page-title-main">RAB4B</span>

Ras-related protein Rab-4B is a protein that in humans is encoded by the RAB4B gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000144566 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017831 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Rousseau-Merck MF, Zahraoui A, Touchot N, Tavitian A, Berger R (Feb 1991). "Chromosome assignment of four RAS-related RAB genes". Human Genetics. 86 (4): 350–4. doi:10.1007/BF00201831. PMID   1999336. S2CID   30730416.
  6. "Entrez Gene: RAB5A RAB5A, member RAS oncogene family".
  7. Huotari J, Helenius A (Aug 2011). "Endosome maturation". The EMBO Journal. 30 (17): 3481–500. doi:10.1038/emboj.2011.286. PMC   3181477 . PMID   21878991.
  8. Zhang C, Li A, Zhang X, Xiao H (Mar 2011). "A novel TIP30 protein complex regulates EGF receptor signaling and endocytic degradation". The Journal of Biological Chemistry. 286 (11): 9373–81. doi: 10.1074/jbc.M110.207720 . PMC   3058969 . PMID   21252234.
  9. Anant JS, Desnoyers L, Machius M, Demeler B, Hansen JC, Westover KD, Deisenhofer J, Seabra MC (Sep 1998). "Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex". Biochemistry. 37 (36): 12559–68. doi:10.1021/bi980881a. PMID   9730828.
  10. Cremers FP, Armstrong SA, Seabra MC, Brown MS, Goldstein JL (Jan 1994). "REP-2, a Rab escort protein encoded by the choroideremia-like gene". The Journal of Biological Chemistry. 269 (3): 2111–7. doi: 10.1016/S0021-9258(17)42142-9 . PMID   8294464.
  11. Xiao GH, Shoarinejad F, Jin F, Golemis EA, Yeung RS (Mar 1997). "The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis". The Journal of Biological Chemistry. 272 (10): 6097–100. doi: 10.1074/jbc.272.10.6097 . hdl: 20.500.12613/9244 . PMID   9045618.
  12. Vitale G, Rybin V, Christoforidis S, Thornqvist P, McCaffrey M, Stenmark H, Zerial M (Apr 1998). "Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5". The EMBO Journal. 17 (7): 1941–51. doi:10.1093/emboj/17.7.1941. PMC   1170540 . PMID   9524117.
  13. Stenmark H, Vitale G, Ullrich O, Zerial M (Nov 1995). "Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion". Cell. 83 (3): 423–32. doi: 10.1016/0092-8674(95)90120-5 . PMID   8521472. S2CID   18768939.
  14. Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T (Nov 2001). "Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER". FEBS Letters. 508 (2): 201–9. doi: 10.1016/s0014-5793(01)02993-3 . PMID   11718716. S2CID   21545088.
  15. Tomoda T, Kim JH, Zhan C, Hatten ME (Mar 2004). "Role of Unc51.1 and its binding partners in CNS axon outgrowth". Genes & Development. 18 (5): 541–58. doi:10.1101/gad.1151204. PMC   374236 . PMID   15014045.
  16. Nielsen E, Christoforidis S, Uttenweiler-Joseph S, Miaczynska M, Dewitte F, Wilm M, Hoflack B, Zerial M (Oct 2000). "Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain". The Journal of Cell Biology. 151 (3): 601–12. doi:10.1083/jcb.151.3.601. PMC   2185588 . PMID   11062261.

Further reading