ZFYVE20

RBSN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YZM, 1Z0J, 1Z0K
Identifiers
Aliases	RBSN , Rabenosyn-5, ZFYVE20, rabenosyn, RAB effector
External IDs	OMIM: 609511 MGI: 1925537 HomoloGene: 41477 GeneCards: RBSN
Gene location (Human)
Chr.	Chromosome 3 (human)
End	15,099,163 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	92,191,906 bp
RNA expression pattern
	Top expressed in
	substantia nigra; ; corpus callosum; ; sural nerve; ; neocortex; ; middle temporal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	zinc ion binding ; metal ion binding ; GO:0001948 protein binding ; nucleic acid binding ;
Cellular component	endosome ; early endosome membrane ; intracellular membrane-bounded organelle ; membrane ; cytoplasmic side of endosome membrane ; plasma membrane ; endosome membrane ; extracellular exosome ; cytosol ;
Biological process	endosomal vesicle fusion ; endocytosis ; vacuole inheritance ; Golgi to endosome transport ; blood coagulation ; endosomal transport ; protein transport ; regulation of Golgi organization ; Golgi to lysosome transport ; early endosome to Golgi transport ; transport ;
	Sources:Amigo / QuickGO
Orthologs
	64145
	78287
	ENSG00000131381
	ENSMUSG00000014550
	Q9H1K0
	Q80Y56
	NM_001302378 ; NM_022340
	NM_030081
	NP_001289307 ; NP_071735
	NP_084357
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 28, 2022

Rabenosyn-5 is a protein that in humans is encoded by the ZFYVE20 gene.^[5]^[6]

Interactions

ZFYVE20 has been shown to interact with RAB5A.^[5]

Related Research Articles

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Ras-related protein Rab-37 is a protein that in humans is encoded by the RAB37 gene.

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Zinc finger FYVE domain-containing protein 19 is a protein that in humans is encoded by the ZFYVE19 gene.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131381 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014550 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Nielsen E, Christoforidis S, Uttenweiler-Joseph S, Miaczynska M, Dewitte F, Wilm M, Hoflack B, Zerial M (Nov 2000). "Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain". J Cell Biol. 151 (3): 601–12. doi:10.1083/jcb.151.3.601. PMC 2185588 . PMID 11062261.
↑ "Entrez Gene: ZFYVE20 zinc finger, FYVE domain containing 20".

Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Eathiraj S, Pan X, Ritacco C, Lambright DG (2005). "Structural basis of family-wide Rab GTPase recognition by rabenosyn-5". Nature. 436 (7049): 415–9. doi:10.1038/nature03798. PMC 1360218 . PMID 16034420.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Naslavsky N, Boehm M, Backlund PS, Caplan S (2005). "Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane". Mol. Biol. Cell. 15 (5): 2410–22. doi:10.1091/mbc.E03-10-0733. PMC 404033 . PMID 15020713.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
de Renzis S, Sönnichsen B, Zerial M (2002). "Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes". Nat. Cell Biol. 4 (2): 124–33. doi:10.1038/ncb744. PMID 11788822. S2CID 6596498.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000131381 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014550 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11062261-5] 1 2 Nielsen E, Christoforidis S, Uttenweiler-Joseph S, Miaczynska M, Dewitte F, Wilm M, Hoflack B, Zerial M (Nov 2000). "Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain". J Cell Biol. 151 (3): 601–12. doi:10.1083/jcb.151.3.601. PMC 2185588 . PMID 11062261.

[entrez-6] "Entrez Gene: ZFYVE20 zinc finger, FYVE domain containing 20".

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ZFYVE20

Contents

Interactions

Related Research Articles

References

Further reading