GCC1

GCC1
Identifiers
Aliases	GCC1 , GCC1P, GCC88, GRIP and coiled-coil domain containing 1
External IDs	OMIM: 607418 MGI: 1921625 HomoloGene: 11567 GeneCards: GCC1
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q32.1 Start 127,580,628 bp [1] End 127,593,611 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 A3.3 Start 28,416,090 bp [2] End 28,428,389 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte islet of Langerhans stromal cell of endometrium blood sperm nipple bone marrow monocyte amniotic fluid thymus Top expressed in supraoptic nucleus ascending aorta spermatocyte islet of Langerhans aortic valve stria vascularis spermatid jejunum intestinal villus molar More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 79571 74375 Ensembl ENSG00000179562 ENSMUSG00000029708 UniProt Q96CN9 Q9D4H2 RefSeq (mRNA) NM_024523 NM_028900 RefSeq (protein) NP_078799 NP_083176 Location (UCSC) Chr 7: 127.58 – 127.59 Mb Chr 6: 28.42 – 28.43 Mb PubMed search [3] [4]
Wikidata
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GRIP and coiled-coil domain-containing protein 1 is a protein that in humans is encoded by the GCC1 gene. ^{[5] [6]}

Function

The protein encoded by this gene is a peripheral membrane protein. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. It may play a role in the organization of trans-Golgi network subcompartment involved with membrane transport. ^[6]

Interactions

GCC1 has been shown to interact with TRIM29. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000179562 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029708 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kjer-Nielsen L, Teasdale RD, van Vliet C, Gleeson PA (May 1999). "A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins". Curr. Biol. 9 (7): 385–8. doi: 10.1016/S0960-9822(99)80168-7 . PMID   10209125. S2CID   14342088.
6. "Entrez Gene: GCC1 GRIP and coiled-coil domain containing 1".
7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

Further reading

• Luke MR, Kjer-Nielsen L, Brown DL, Stow JL, Gleeson PA (2003). "GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network". J. Biol. Chem. 278 (6): 4216–26. doi: 10.1074/jbc.M210387200 . PMID   12446665.
• Lu L, Hong W (2003). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Mol. Biol. Cell. 14 (9): 3767–81. doi:10.1091/mbc.E03-01-0864. PMC   196566 . PMID   12972563.
• Luke MR, Houghton F, Perugini MA, Gleeson PA (2005). "The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers". Biochem. J. 388 (Pt 3): 835–41. doi:10.1042/BJ20041810. PMC   1183463 . PMID   15654769.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.