GRIP and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the GCC2 gene. [4] [5]
The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [5]
Cux1 is a homeodomain protein that in humans is encoded by the CUX1 gene.
Golgi-associated PDZ and coiled-coil motif-containing protein is a protein that in humans is encoded by the GOPC gene.
Transmembrane emp24 domain-containing protein 10 is a protein that in humans is encoded by the TMED10 gene.
Golgin subfamily A member 3 is a protein that in humans is encoded by the GOLGA3 gene.
Golgin subfamily A member 4 is a protein that in humans is encoded by the GOLGA4 gene.
Vacuolar protein sorting-associated protein 26A is a protein that in humans is encoded by the VPS26A gene.
Transforming acidic coiled-coil-containing protein 2 is a protein that in humans is encoded by the TACC2 gene.
ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1 gene.
BET1-like protein is a protein that in humans is encoded by the BET1L gene.
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ASAP2 gene.
Golgin subfamily A member 5 is a protein that in humans is encoded by the GOLGA5 gene.
Vacuolar protein sorting-associated protein 45 is a protein that in humans is encoded by the VPS45 gene.
Matrilin-2 is a matrilin protein that in humans is encoded by the MATN2 gene.
Cytohesin-3 is a protein that in humans is encoded by the CYTH3 gene.
Dynactin subunit 3 is a protein that in humans is encoded by the DCTN3 gene.
Golgin subfamily A member 1 is a protein that in humans is encoded by the GOLGA1 gene.
GRIP and coiled-coil domain-containing protein 1 is a protein that in humans is encoded by the GCC1 gene.
Copine-4 is a protein that in humans is encoded by the CPNE4 gene.
Giantin or Golgin subfamily B member 1 is a protein that in humans is encoded by the GOLGB1 gene. Giantin is located at the cis-medial rims of the Golgi apparatus and is part of the Golgi matrix that is responsible for membrane trafficking in secretory pathway of proteins. This function is key for proper localisation of proteins at the plasma membrane and outside the cell which is important for cell function that is dependent on for example receptors and the extracellular matrix function. Recent animal model knockout studies of GOLGB1 in mice, rat, and zebrafish have shown that phenotypes are different between species ranging from mild to severe craniofacial defects in the rodent models to just minor size defects in zebrafish. However, in adult zebrafish a tumoral calcinosis-like phenotype was observed, and in humans such phenotype has been linked to defective glycosyltransferase function.
The Golgi matrix is a collection of proteins involved in the structure and function of the Golgi apparatus. The matrix was first isolated in 1994 as an amorphous collection of 12 proteins that remained associated together in the presence of detergent and 150 mM NaCl. Treatment with a protease enzyme removed the matrix, which confirmed the importance of proteins for the matrix structure. Modern freeze etch electron microscopy (EM) clearly shows a mesh connecting Golgi cisternae and associated vesicles. Further support for the existence of a matrix comes from EM images showing that ribosomes are excluded from regions between and near Golgi cisternae.
 | This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it. |
