GEFT

ARHGEF25
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RGN
Identifiers
Aliases	ARHGEF25 , GEFT, p63RhoGEF, Rho guanine nucleotide exchange factor 25
External IDs	OMIM: 610215; MGI: 1277173; HomoloGene: 32691; GeneCards: ARHGEF25; OMA:ARHGEF25 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.3 Start 57,610,180 bp [1] End 57,617,245 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 D3|10 74.5 cM Start 127,018,394 bp [2] End 127,025,952 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right coronary artery gastric mucosa body of uterus muscle layer of sigmoid colon popliteal artery tibial arteries left uterine tube myometrium thoracic aorta Top expressed in dentate gyrus of hippocampal formation granule cell hippocampus proper CA3 field primary visual cortex primary motor cortex superior frontal gyrus vas deferens Region I of hippocampus proper umbilical cord lateral septal nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function guanyl-nucleotide exchange factor activity Cellular component cytoplasm cytosol plasma membrane myofibril sarcomere membrane Biological process regulation of Rho protein signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 115557 52666 Ensembl ENSG00000240771 ENSMUSG00000019467 UniProt Q86VW2 Q9CWR0 RefSeq (mRNA) NM_001111270 NM_133483 NM_182947 NM_001347933 NM_001166413 NM_028027 NM_001358557 NM_001358558 RefSeq (protein) NP_001104740 NP_891992 NP_001334862 NP_001159885 NP_082303 NP_001345486 NP_001345487 Location (UCSC) Chr 12: 57.61 – 57.62 Mb Chr 10: 127.02 – 127.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RAC/CDC42 exchange factor, also known as GEFT, is a human gene. ^[5]

Interactions

GEFT has been shown to interact with RHOA. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000240771 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019467 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GEFT RAC/CDC42 exchange factor".
6. Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T (May 2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn-Schmiedeberg's Arch. Pharmacol. 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. PMID   15069594. S2CID   19812449.

Further reading

• Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ (2008). "Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs". Science. 318 (5858): 1923–7. doi:10.1126/science.1147554. PMID   18096806. S2CID   2418867.
• Bryan BA, Cai Y, Liu M (2006). "The Rho-family guanine nucleotide exchange factor GEFT enhances retinoic acid- and cAMP-induced neurite outgrowth". J. Neurosci. Res. 83 (7): 1151–9. doi:10.1002/jnr.20814. PMID   16496360. S2CID   11130365.
• Bryan BA, Mitchell DC, Zhao L, Ma W, Stafford LJ, Teng BB, Liu M (2006). "Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT". Mol. Cell. Biol. 25 (24): 11089–101. doi:10.1128/MCB.25.24.11089-11101.2005. PMC   1316953 . PMID   16314529.
• Lutz S, Freichel-Blomquist A, Yang Y, Rümenapp U, Jakobs KH, Schmidt M, Wieland T (2005). "The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA". J. Biol. Chem. 280 (12): 11134–9. doi: 10.1074/jbc.M411322200 . PMID   15632174.
• Bryan B, Kumar V, Stafford LJ, Cai Y, Wu G, Liu M (2004). "GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation". J. Biol. Chem. 279 (44): 45824–32. doi: 10.1074/jbc.M406216200 . PMID   15322108.
• Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T (2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn-Schmiedeberg's Arch. Pharmacol. 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. PMID   15069594. S2CID   19812449.
• Guo X, Stafford LJ, Bryan B, Xia C, Ma W, Wu X, Liu D, Songyang Z, Liu M (2003). "A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration". J. Biol. Chem. 278 (15): 13207–15. doi: 10.1074/jbc.M208896200 . PMID   12547822.
• Souchet M, Portales-Casamar E, Mazurais D, Schmidt S, Léger I, Javré JL, Robert P, Berrebi-Bertrand I, Bril A, Gout B, Debant A, Calmels TP (2002). "Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere". J. Cell Sci. 115 (Pt 3): 629–40. doi:10.1242/jcs.115.3.629. PMID   11861769.