GGA1

GGA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1J2J, 1JWF, 1JWG, 1NA8, 1NAF, 1NWM, 1O3X, 1OM9, 1OXZ, 1PY1, 1UJJ, 1UJK, 1X79, 2DWX, 2DWY, 3G2S, 3G2T, 3G2U, 3G2V, 3G2W
Identifiers
Aliases	GGA1 , golgi associated, gamma adaptin ear containing, ARF binding protein 1
External IDs	OMIM: 606004; MGI: 2146207; HomoloGene: 39250; GeneCards: GGA1; OMA:GGA1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.1 Start 37,608,725 bp [1] End 37,633,564 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E1 Start 78,761,390 bp [2] End 78,778,785 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell left testis right testis endothelial cell right uterine tube mucosa of ileum right hemisphere of cerebellum pituitary gland gingival epithelium anterior pituitary Top expressed in granulocyte muscle of thigh lip pyloric antrum yolk sac superior frontal gyrus ventricular zone dentate gyrus of hippocampal formation granule cell primary visual cortex esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein heterodimerization activity molecular function Cellular component endosome Golgi apparatus endosome membrane intracellular anatomical structure membrane intracellular membrane-bounded organelle clathrin adaptor complex nucleoplasm early endosome membrane early endosome cytosol protein-containing complex Biological process protein transport intracellular protein transport toxin transport positive regulation of protein catabolic process vesicle-mediated transport transport Golgi to plasma membrane transport protein localization protein localization to cell surface retrograde transport, endosome to Golgi Golgi to plasma membrane protein transport protein localization to ciliary membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26088 106039 Ensembl ENSG00000100083 ENSMUSG00000033128 UniProt Q9UJY5 Q8R0H9 RefSeq (mRNA) NM_001001560 NM_001001561 NM_001172687 NM_001172688 NM_013365 NM_001363771 NM_145929 RefSeq (protein) NP_001001560 NP_001166158 NP_001166159 NP_037497 NP_001350700 NP_666041 Location (UCSC) Chr 22: 37.61 – 37.63 Mb Chr 15: 78.76 – 78.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene. ^{[5] [6] [7]}

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. ^[8]

Interactions

GGA1 has been shown to interact with Sortilin 1, ^[9] BACE2, ^[10] RABEP1 ^[11] and ARF3. ^{[12] [13]}

References

1. GRCh38: Ensembl release 89: ENSG00000100083 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033128 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (May 2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". J Cell Biol. 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC   2175106 . PMID   10747088.
6. Dell'Angelica EC, Puertollano R, Mullins C, Aguilar RC, Vargas JD, Hartnell LM, Bonifacino JS (May 2000). "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex". J Cell Biol. 149 (1): 81–94. doi:10.1083/jcb.149.1.81. PMC   2175099 . PMID   10747089.
7. Xie L, Boyle D, Sanford D, Scherer PE, Pessin JE, Mora S (March 2006). "Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles". J Biol Chem. 281 (11): 7253–9. doi: 10.1074/jbc.M511313200 . hdl: 2445/176753 . PMID   16407204.
8. "Entrez Gene: GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1".
9. Jacobsen, Linda; Madsen Peder; Nielsen Morten S; Geraerts Wijnand P M; Gliemann Jørgen; Smit August B; Petersen Claus M (January 2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Lett. 511 (1–3): 155–8. doi: 10.1016/S0014-5793(01)03299-9 . ISSN   0014-5793. PMID   11821067. S2CID   21977507.
10. He, Xiangyuan; Chang Wan-Pin; Koelsch Gerald; Tang Jordan (July 2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2". FEBS Lett. 524 (1–3): 183–7. doi: 10.1016/S0014-5793(02)03052-1 . ISSN   0014-5793. PMID   12135764.
11. Mattera, Rafael; Arighi Cecilia N; Lodge Robert; Zerial Marino; Bonifacino Juan S (January 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". EMBO J. 22 (1): 78–88. doi:10.1093/emboj/cdg015. ISSN   0261-4189. PMC   140067 . PMID   12505986.
12. Boman, Annette L; Salo Paul D; Hauglund Melissa J; Strand Nicole L; Rensink Shelly J; Zhdankina Olga (September 2002). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Mol. Biol. Cell. 13 (9): 3078–95. doi:10.1091/mbc.E02-02-0078. ISSN   1059-1524. PMC   124144 . PMID   12221117.
13. Boman, A L; Zhang C j; Zhu X; Kahn R A (April 2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Mol. Biol. Cell. 11 (4): 1241–55. doi:10.1091/mbc.11.4.1241. ISSN   1059-1524. PMC   14844 . PMID   10749927.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Boman AL, Zhang C, Zhu X, Kahn RA (2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Mol. Biol. Cell. 11 (4): 1241–55. doi:10.1091/mbc.11.4.1241. PMC   14844 . PMID   10749927.
• Takatsu H, Yoshino K, Nakayama K (2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID   10814529.
• Zhdankina O, Strand NL, Redmond JM, Boman AL (2001). "Yeast GGA proteins interact with GTP-bound Arf and facilitate transport through the Golgi". Yeast. 18 (1): 1–18. doi: 10.1002/1097-0061(200101)18:1<1::AID-YEA644>3.0.CO;2-5 . PMID   11124697. S2CID   10348751.
• Puertollano R, Randazzo PA, Presley JF, et al. (2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell. 105 (1): 93–102. doi: 10.1016/S0092-8674(01)00299-9 . PMID   11301005.
• Puertollano R, Aguilar RC, Gorshkova I, et al. (2001). "Sorting of mannose 6-phosphate receptors mediated by the GGAs". Science. 292 (5522): 1712–6. Bibcode:2001Sci...292.1712P. doi:10.1126/science.1060750. PMID   11387475. S2CID   30836125.
• Takatsu H, Katoh Y, Shiba Y, Nakayama K (2001). "Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains". J. Biol. Chem. 276 (30): 28541–5. doi: 10.1074/jbc.C100218200 . PMID   11390366.
• Jacobsen L, Madsen P, Nielsen MS, et al. (2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Lett. 511 (1–3): 155–8. doi: 10.1016/S0014-5793(01)03299-9 . PMID   11821067. S2CID   21977507.
• Shiba T, Takatsu H, Nogi T, et al. (2002). "Structural basis for recognition of acidic-cluster dileucine sequence by GGA1". Nature. 415 (6874): 937–41. Bibcode:2002Natur.415..937S. doi:10.1038/415937a. PMID   11859376. S2CID   4395774.
• Takatsu H, Yoshino K, Toda K, Nakayama K (2002). "GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors". Biochem. J. 365 (Pt 2): 369–78. doi:10.1042/BJ20020428. PMC   1222692 . PMID   11950392.
• Doray B, Bruns K, Ghosh P, Kornfeld SA (2002). "Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 8072–7. Bibcode:2002PNAS...99.8072D. doi: 10.1073/pnas.082235699 . PMC   123022 . PMID   12060753.
• He X, Chang WP, Koelsch G, Tang J (2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2". FEBS Lett. 524 (1–3): 183–7. doi: 10.1016/S0014-5793(02)03052-1 . PMID   12135764.
• Boman AL, Salo PD, Hauglund MJ, et al. (2003). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Mol. Biol. Cell. 13 (9): 3078–95. doi:10.1091/mbc.E02-02-0078. PMC   124144 . PMID   12221117.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mattera R, Arighi CN, Lodge R, et al. (2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". EMBO J. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC   140067 . PMID   12505986.
• Mills IG, Praefcke GJ, Vallis Y, et al. (2003). "EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking". J. Cell Biol. 160 (2): 213–22. doi:10.1083/jcb.200208023. PMC   2172650 . PMID   12538641.