GIMAP4

GIMAP4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LXX
Identifiers
Aliases	GIMAP4 , IAN-1, IAN1, IMAP4, MSTP062, GTPase, IMAP family member 4
External IDs	OMIM: 608087 MGI: 1349656 HomoloGene: 75084 GeneCards: GIMAP4
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	48,668,994 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; right lung; ; lymph node; ; spleen; ; appendix; ; superficial temporal artery; ; pericardium; ; Achilles tendon; ; lower lobe of lung;
	Top expressed in
	spleen; ; right lung lobe; ; left lung; ; left lung lobe; ; renal corpuscle; ; blood; ; thymus; ; carotid body; ; subcutaneous adipose tissue; ; adrenal gland;
	More reference expression data
	More reference expression data
Orthologs
	55303
	107526
	n/a
	ENSMUSG00000054435
	Q9NUV9
	Q99JY3
	NM_018326 ; NM_001363532
	NM_001243199 ; NM_001243200 ; NM_001243201 ; NM_174990 ; NM_175048
	NP_060796 ; NP_001350461
	NP_001230128 ; NP_001230129 ; NP_001230130 ; NP_778155 ; NP_778213
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 03, 2023

GTPase IMAP family member 4 is an enzyme that in humans is encoded by the GIMAP4 gene.^[4]^[5]^[6]

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein of this gene may be negatively regulated by T-cell acute lymphocytic leukemia 1 (TAL1). In humans, the IAN subfamily genes are located in a cluster at 7q36.1.^[6]

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References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054435 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Krucken J, Schroetel RM, Muller IU, Saidani N, Marinovski P, Benten WP, Stamm O, Wunderlich F (Oct 2004). "Comparative analysis of the human gimap gene cluster encoding a novel GTPase family". Gene. 341: 291–304. doi:10.1016/j.gene.2004.07.005. PMID 15474311.
↑ Filen JJ, Filen S, Moulder R, Tuomela S, Ahlfors H, West A, Kouvonen P, Kantola S, Bjorkman M, Katajamaa M, Rasool O, Nyman TA, Lahesmaa R (Jan 2009). "Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation". Mol Cell Proteomics. 8 (1): 32–44. doi:10.1074/mcp.M800139-MCP200. PMC 2621005 . PMID 18701445.
1 2 "Entrez Gene: GIMAP4 GTPase, IMAP family member 4".

Dominguez O, Ashhab Y, Sabater L, et al. (1999). "Cloning of ARE-containing genes by AU-motif-directed display". Genomics. 54 (2): 278–86. doi:10.1006/geno.1998.5548. PMID 9828130.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC 16267 . PMID 10737800.
Stamm O, Krücken J, Schmitt-Wrede HP, et al. (2002). "Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36". Gene. 282 (1–2): 159–67. doi:10.1016/S0378-1119(01)00837-X. PMID 11814688.
Cambot M, Aresta S, Kahn-Perlès B, et al. (2002). "Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells". Blood. 99 (9): 3293–301. doi: 10.1182/blood.V99.9.3293 . PMID 11964296.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961 . PMID 12690205.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Nitta T, Nasreen M, Seike T, et al. (2006). "IAN family critically regulates survival and development of T lymphocytes". PLOS Biol. 4 (4): e103. doi: 10.1371/journal.pbio.0040103 . PMC 1393758 . PMID 16509771.

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[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054435 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15474311-4] Krucken J, Schroetel RM, Muller IU, Saidani N, Marinovski P, Benten WP, Stamm O, Wunderlich F (Oct 2004). "Comparative analysis of the human gimap gene cluster encoding a novel GTPase family". Gene. 341: 291–304. doi:10.1016/j.gene.2004.07.005. PMID 15474311.

[pmid18701445-5] Filen JJ, Filen S, Moulder R, Tuomela S, Ahlfors H, West A, Kouvonen P, Kantola S, Bjorkman M, Katajamaa M, Rasool O, Nyman TA, Lahesmaa R (Jan 2009). "Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation". Mol Cell Proteomics. 8 (1): 32–44. doi:10.1074/mcp.M800139-MCP200. PMC 2621005 . PMID 18701445.

[entrez-6] 1 2 "Entrez Gene: GIMAP4 GTPase, IMAP family member 4".

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GIMAP4

Related Research Articles

References

Further reading