GIMAP4

GIMAP4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LXX
Identifiers
Aliases	GIMAP4 , IAN-1, IAN1, IMAP4, MSTP062, GTPase, IMAP family member 4
External IDs	OMIM: 608087; MGI: 1349656; HomoloGene: 75084; GeneCards: GIMAP4; OMA:GIMAP4 - orthologs
Gene location (Mouse) Chr. Chromosome 6 (mouse) [1] Band 6|6 B2.3 Start 48,661,483 bp [1] End 48,668,994 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood right lung lymph node spleen appendix superficial temporal artery pericardium Achilles tendon lower lobe of lung Top expressed in mesenteric lymph nodes spleen right lung lobe left lung left lung lobe renal corpuscle blood thymus carotid body subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 55303 107526 Ensembl n/a ENSMUSG00000054435 UniProt Q9NUV9 Q99JY3 RefSeq (mRNA) NM_018326 NM_001363532 NM_001243199 NM_001243200 NM_001243201 NM_174990 NM_175048 RefSeq (protein) NP_060796 NP_001350461 NP_001230128 NP_001230129 NP_001230130 NP_778155 NP_778213 Location (UCSC) n/a Chr 6: 48.66 – 48.67 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

GTPase IMAP family member 4 is an enzyme that in humans is encoded by the GIMAP4 gene. ^{[4] [5] [6]}

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein of this gene may be negatively regulated by T-cell acute lymphocytic leukemia 1 (TAL1). In humans, the IAN subfamily genes are located in a cluster at 7q36.1. ^[6]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000054435 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Krucken J, Schroetel RM, Muller IU, Saidani N, Marinovski P, Benten WP, Stamm O, Wunderlich F (Oct 2004). "Comparative analysis of the human gimap gene cluster encoding a novel GTPase family". Gene. 341: 291–304. doi:10.1016/j.gene.2004.07.005. PMID   15474311.
5. Filen JJ, Filen S, Moulder R, Tuomela S, Ahlfors H, West A, Kouvonen P, Kantola S, Bjorkman M, Katajamaa M, Rasool O, Nyman TA, Lahesmaa R (Jan 2009). "Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation". Mol Cell Proteomics. 8 (1): 32–44. doi: 10.1074/mcp.M800139-MCP200 . PMC   2621005 . PMID   18701445.
6. "Entrez Gene: GIMAP4 GTPase, IMAP family member 4".

Further reading

• Dominguez O, Ashhab Y, Sabater L, et al. (1999). "Cloning of ARE-containing genes by AU-motif-directed display". Genomics. 54 (2): 278–86. doi:10.1006/geno.1998.5548. PMID   9828130.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Stamm O, Krücken J, Schmitt-Wrede HP, et al. (2002). "Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36". Gene. 282 (1–2): 159–67. doi:10.1016/S0378-1119(01)00837-X. PMID   11814688.
• Cambot M, Aresta S, Kahn-Perlès B, et al. (2002). "Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells". Blood. 99 (9): 3293–301. doi: 10.1182/blood.V99.9.3293 . PMID   11964296.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Nitta T, Nasreen M, Seike T, et al. (2006). "IAN family critically regulates survival and development of T lymphocytes". PLOS Biol. 4 (4): e103. doi: 10.1371/journal.pbio.0040103 . PMC   1393758 . PMID   16509771.