GINS2

GINS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E9X, 2EHO, 2Q9Q
Identifiers
Aliases	GINS2 , HSPC037, PSF2, Pfs2, GINS complex subunit 2
External IDs	OMIM: 610609 MGI: 1921019 HomoloGene: 41105 GeneCards: GINS2
Gene location (Human)
Chr.	Chromosome 16 (human)
End	85,690,073 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	121,316,043 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; embryo; ; ganglionic eminence; ; sperm; ; bone marrow; ; cancellous bone; ; rectum; ; bone marrow cells; ; cavity of mouth;
	Top expressed in
	yolk sac; ; blastocyst; ; primitive streak; ; secondary oocyte; ; endocardial cushion; ; renal corpuscle; ; medial ganglionic eminence; ; abdominal wall; ; internal carotid artery; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	3'-5' DNA helicase activity ; protein binding ;
Cellular component	GINS complex ; replication fork protection complex ; nucleus ; nucleoplasm ;
Biological process	DNA replication ; DNA strand elongation involved in DNA replication ; double-strand break repair via break-induced replication ; mitotic DNA replication initiation ; DNA duplex unwinding ;
	Sources:Amigo / QuickGO
Orthologs
	51659
	272551
	ENSG00000131153
	ENSMUSG00000031821
	Q9Y248
	Q9D600
	NM_016095
	NM_178856
	NP_057179
	NP_849187
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 29, 2022

DNA replication complex GINS protein PSF2 is a protein that in humans is encoded by the GINS2 gene.^[5]^[6]^[7]

Interactions

GINS2 has been shown to interact with CHEK2.^[8]

Related Research Articles

CHEK2 is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linked to a wide range of cancers.

Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans.

Mediator of RNA polymerase II transcription subunit 4 also known as mediator complex subunit 4 (MED4), a component of Mediator or vitamin D3 receptor-interacting protein complex 36 kDa component (DRIP36) is a protein that in humans is encoded by the MED4 gene.

Probable E3 ubiquitin-protein ligase MYCBP2 also known as myc-binding protein 2 or protein associates with myc (PAM) is an enzyme that in humans is encoded by the MYCBP2 gene.

Origin recognition complex subunit 3 is a protein that in humans is encoded by the ORC3 (ORC3L) gene.

Vesicle-trafficking protein SEC22b is a protein that in humans is encoded by the SEC22B gene.

BRCA1-A complex subunit RAP80 is a protein that in humans is encoded by the UIMC1 gene.

28S ribosomal protein L42, mitochondrial is a protein that in humans is encoded by the MRPL42 gene.

Small EDRK-rich factor 2 is a protein that in humans is encoded by the SERF2 gene.

39S ribosomal protein L18, mitochondrial is a protein that in humans is encoded by the MRPL18 gene.

Coatomer subunit zeta-1 is a protein that in humans is encoded by the COPZ1 gene.

SARAF is a protein that in humans is encoded by the SARAF gene, formerly known as TMEM66.

Zinc finger CCHC domain-containing protein 8 is a protein that in humans is encoded by the ZCCHC8 gene.

Coiled-coil domain-containing protein 113 also known as HSPC065, GC16Pof6842 and GC16P044152, is a protein that in humans is encoded by the CCDC113 gene. The human CCDC113 gene is located on chromosome 16q21 and encodes 5,304 base pairs of mRNA and 377 amino acids.

RING finger protein 220 is a protein that in humans is encoded by the RNF220 gene.

39S ribosomal protein L33, mitochondrial is a protein that in humans is encoded by the MRPL33 gene.

CTU2 is a human gene located on chromosome 16. The mRNA encodes the longer isoform. The gene encodes a cytoplasmic protein that plays a probable role in tRNA modification.

PDZ domain-containing protein GIPC3 is a protein that in humans is encoded by the GIPC3 gene. GIPC3 is a member of the GIPC gene family that also includes GIPC1 and GIPC2. The encoded protein, GIPC3, features a centrally located PDZ domain, which is flanked on each side by a single GIPC-homology domain.

Glutamine Serine Rich Protein 1 or QSER1 is a protein encoded by the QSER1 gene.

Uncharacterized protein C1orf131 is a protein that in humans is encoded by the gene C1orf131. The first ortholog of this protein was discovered in humans. Subsequently, through the use of algorithms and bioinformatics, homologs of C1orf131 have been discovered in numerous species, and as a result, the name of the majority of the proteins in this protein family is Uncharacterized protein C1orf131 homolog.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131153 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031821 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934 . PMID 11042152.
↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876 . PMID 10810093.
↑ "Entrez Gene: GINS2 GINS complex subunit 2 (Psf2 homolog)".
↑ Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ (May 2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science. 316 (5828): 1160–6. Bibcode:2007Sci...316.1160M. doi:10.1126/science.1140321. PMID 17525332. S2CID 16648052.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Takayama Y, Kamimura Y, Okawa M, Muramatsu S, Sugino A, Araki H (2003). "GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast". Genes Dev. 17 (9): 1153–65. doi:10.1101/gad.1065903. PMC 196052 . PMID 12730134.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ (2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science. 316 (5828): 1160–6. Bibcode:2007Sci...316.1160M. doi:10.1126/science.1140321. PMID 17525332. S2CID 16648052.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000131153 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031821 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11042152-5] Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934 . PMID 11042152.

[pmid10810093-6] Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876 . PMID 10810093.

[entrez-7] "Entrez Gene: GINS2 GINS complex subunit 2 (Psf2 homolog)".

[pmid17525332-8] Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ (May 2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science. 316 (5828): 1160–6. Bibcode:2007Sci...316.1160M. doi:10.1126/science.1140321. PMID 17525332. S2CID 16648052.

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GINS2

Contents

Interactions

Related Research Articles

References

Further reading