GNL3

GNL3
Identifiers
Aliases	GNL3 , C77032, E2IG3, NNP47, NS, G protein nucleolar 3
External IDs	OMIM: 608011; MGI: 1353651; HomoloGene: 56670; GeneCards: GNL3; OMA:GNL3 - orthologs
Gene location (Mouse) Chr. Chromosome 14 (mouse) [1] Band 14 B|14 19.09 cM Start 30,734,390 bp [1] End 30,741,109 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon body of pancreas islet of Langerhans minor salivary glands rectum thymus peritoneum skin of abdomen anterior pituitary left uterine tube Top expressed in tail of embryo epiblast genital tubercle embryo morula embryo ovary uterus blastocyst placenta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding RNA binding GTPase activity mRNA 5'-UTR binding Cellular component membrane nucleus nucleoplasm nucleolus extracellular space nuclear body Biological process positive regulation of protein localization to chromosome, telomeric region positive regulation of telomere maintenance cell population proliferation regulation of cell population proliferation positive regulation of pri-miRNA transcription by RNA polymerase II positive regulation of protein sumoylation stem cell division stem cell population maintenance ribosome biogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26354 30877 Ensembl n/a ENSMUSG00000042354 UniProt Q9BVP2 Q8CI11 RefSeq (mRNA) NM_206826 NM_014366 NM_206825 NM_153547 NM_178846 RefSeq (protein) NP_055181 NP_996561 NP_996562 NP_705775 Location (UCSC) n/a Chr 14: 30.73 – 30.74 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Guanine nucleotide-binding protein-like 3, also known as nucleostemin, is a protein that in humans is encoded by the GNL3 gene. ^{[4] [5] [6]} It is found within the nucleolus that binds p53. ^[7] Nucleostemin regulates the cell cycle and affects cell differentiation, decreasing in amount as this differentiation progresses. ^[7] It is a marker for many stem cells and cancer cells. ^[8]

Interactions

GNL3 has been shown to interact with Mdm2 ^[9] and P53. ^[5]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000042354 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Charpentier AH, Bednarek AK, Daniel RL, Hawkins KA, Laflin KJ, Gaddis S, MacLeod MC, Aldaz CM (Nov 2000). "Effects of estrogen on global gene expression: identification of novel targets of estrogen action". Cancer Res. 60 (21): 5977–5983. PMID   11085516.
5. Tsai RY, McKay RD (Dec 2002). "A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells". Genes Dev. 16 (23): 2991–3003. doi:10.1101/gad.55671. PMC   187487 . PMID   12464630.
6. "Entrez Gene: GNL3 guanine nucleotide binding protein-like 3 (nucleolar)".
7. Ross MH, Pawlina W (2011). Histology : a text and atlas : with correlated cell and molecular biolog. Philadelphia: Wolters Kluwer/Lippincott Williams Wilkins Health. p. 79. ISBN   978-0-7817-7200-6.
8. Niall M. Adams (29 November 2010). Advances in Nuclear Architecture. Springer. p. 31. ISBN   978-90-481-9898-6 . Retrieved 27 September 2011.
9. Dai MS, Sun XX, Lu H (Jul 2008). "Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2". Mol. Cell. Biol. 28 (13): 4365–4376. doi:10.1128/MCB.01662-07. PMC   2447154 . PMID   18426907.

Further reading

• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (2002). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–4109. doi:10.1091/mbc.E02-05-0271. PMC   133617 . PMID   12429849.
• Schwartz PH, Bryant PJ, Fuja TJ, Su H, O'Dowd DK, Klassen H (2003). "Isolation and characterization of neural progenitor cells from post-mortem human cortex". J. Neurosci. Res. 74 (6): 838–851. doi:10.1002/jnr.10854. PMID   14648588. S2CID   15252292.
• Liu SJ, Cai ZW, Liu YJ, Dong MY, Sun LQ, Hu GF, Wei YY, Lao WD (2004). "Role of nucleostemin in growth regulation of gastric cancer, liver cancer and other malignancies". World J. Gastroenterol. 10 (9): 1246–1249. doi: 10.3748/wjg.v10.i9.1246 . PMC   4622760 . PMID   15112336.
• Sijin L, Ziwei C, Yajun L, Meiyu D, Hongwei Z, Guofa H, Siguo L, Hong G, Zhihong Z, Xiaolei L, Yingyun W, Yan X, Weide L (2004). "The effect of knocking-down nucleostemin gene expression on the in vitro proliferation and in vivo tumorigenesis of HeLa cells". J. Exp. Clin. Cancer Res. 23 (3): 529–538. PMID   15595646.
• Tsai RY, McKay RD (2005). "A multistep, GTP-driven mechanism controlling the dynamic cycling of nucleostemin". J. Cell Biol. 168 (2): 179–184. doi:10.1083/jcb.200409053. PMC   2171593 . PMID   15657390.
• Politz JC, Polena I, Trask I, Bazett-Jones DP, Pederson T (2005). "A nonribosomal landscape in the nucleolus revealed by the stem cell protein nucleostemin". Mol. Biol. Cell. 16 (7): 3401–3410. doi:10.1091/mbc.E05-02-0106. PMC   1165421 . PMID   15857956.
• Han C, Zhang X, Xu W, Wang W, Qian H, Chen Y (2005). "Cloning of the nucleostemin gene and its function in transforming human embryonic bone marrow mesenchymal stem cells into F6 tumor cells". Int. J. Mol. Med. 16 (2): 205–213. doi:10.3892/ijmm.16.2.205. PMID   16012751.
• Yang HX, Jin GL, Meng L, Zhang JZ, Liu WB, Shou CC (2005). "Screening and identification of proteins interacting with nucleostemin". World J. Gastroenterol. 11 (31): 4812–4814. doi: 10.3748/wjg.v11.i31.4812 . PMC   4398727 . PMID   16097049.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kafienah W, Mistry S, Williams C, Hollander AP (2006). "Nucleostemin is a marker of proliferating stromal stem cells in adult human bone marrow". Stem Cells. 24 (4): 1113–1120. doi:10.1634/stemcells.2005-0416. PMID   16282439. S2CID   20104916.
• Fan Y, Liu Z, Zhao S, Lou F, Nilsson S, Ekman P, Xu D, Fang X (2006). "Nucleostemin mRNA is expressed in both normal and malignant renal tissues". Br. J. Cancer. 94 (11): 1658–1662. doi:10.1038/sj.bjc.6603145. PMC   2361296 . PMID   16670719.
• Lacina L, Smetana K, Dvoránková B, Stork J, Plzáková Z, Gabius HJ (2006). "Immunocyto- and histochemical profiling of nucleostemin expression: marker of epidermal stem cells?". J. Dermatol. Sci. 44 (2): 73–80. doi:10.1016/j.jdermsci.2006.08.008. PMID   17000083.
• Zhu Q, Yasumoto H, Tsai RY (2006). "Nucleostemin delays cellular senescence and negatively regulates TRF1 protein stability". Mol. Cell. Biol. 26 (24): 9279–9290. doi:10.1128/MCB.00724-06. PMC   1698521 . PMID   17000763.
• Liu SJ, Zhang ZH, Zhang DQ, Sui XM, Liu YJ, Cai ZW, Yuan XY, Sun LQ, Hu GF, Liu RL (2006). "Gene profiling after knocking-down expression of nucleostemin in Hela cells using oligonucleotide DNA microarray". J. Exp. Clin. Cancer Res. 25 (4): 575–583. PMID   17310849.