GOLGA5

GOLGA5
Identifiers
Aliases	GOLGA5 , GOLIM5, RFG5, ret-II, golgin A5, GOLGIN 84
External IDs	OMIM: 606918 MGI: 1351475 HomoloGene: 38009 GeneCards: GOLGA5
Gene location (Human)
Chr.	Chromosome 14 (human)
End	92,839,947 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	102,464,166 bp
RNA expression pattern
	Top expressed in
	Right lobe of liver; ; Achilles tendon; ; testicle; ; caput epididymis; ; islet of Langerhans; ; anterior pituitary;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity ;
Cellular component	cis-Golgi network ; Golgi cisterna ; membrane ; Golgi apparatus ; transport vesicle ; Golgi membrane ; integral component of membrane ;
Biological process	Golgi vesicle transport ; Golgi organization ; retrograde transport, vesicle recycling within Golgi ;
	Sources:Amigo / QuickGO
Orthologs
	9950
	27277
	ENSG00000066455
	ENSMUSG00000021192
	Q8TBA6
	Q9QYE6
	NM_005113
	NM_001199004 ; NM_013747
	NP_005104
	NP_001185933 ; NP_038775
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 28, 2022

Golgin subfamily A member 5 is a protein that in humans is encoded by the GOLGA5 gene.^[5]^[6]^[7]^[8]

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins, whose members localize to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5.^[8]

Interactions

GOLGA5 has been shown to interact with RAB1A.^[9]^[10]

Related Research Articles

Ras-related protein Rab-6A is a protein that in humans is encoded by the RAB6A gene located in the eleventh chromosome. Its main function is the regulation of protein transport from the Golgi complex to the endoplasmic reticulum and the exocytosis along with the microtubules.

Golgin subfamily A member 2 is a protein that in humans is encoded by the GOLGA2 gene.

Cux1 is a homeodomain protein that in humans is encoded by the CUX1 gene.

General vesicular transport factor p115 is a protein that in humans is encoded by the USO1 gene.

Ras-related protein Rab-1A is a protein that in humans is encoded by the RAB1A gene.

Ras-related protein Rab-1B is a protein that in humans is encoded by the RAB1B gene.

Golgin subfamily A member 3 is a protein that in humans is encoded by the GOLGA3 gene.

Golgin subfamily A member 4 is a protein that in humans is encoded by the GOLGA4 gene.

Bicaudal D cargo adaptor 2 is a protein that in humans is encoded by the BICD2 gene.

Golgi reassembly-stacking protein of 55 kDa (GRASP55) also known as golgi reassembly-stacking protein 2 (GORASP2) is a protein that in humans is encoded by the GORASP2 gene. It was identified by its homology with GRASP65 and the protein's amino acid sequence was determined by analysis of a molecular clone of its complementary DNA. The first (N-terminus) 212 amino acid residues of GRASP55 are highly homologous to those of GRASP65, but the remainder of the 454 amino acid residues are highly diverged from GRASP65. The conserved region is known as the GRASP domain, and it is conserved among GRASPs of a wide variety of eukaryotes, but not plants. The C-terminus portion of the molecule is called the SPR domain. GRASP55 is more closely related to homologues in other species, suggesting that GRASP55 is ancestral to GRASP65. GRASP55 is found associated with the medial and trans cisternae of the Golgi apparatus.

Ras-related protein Rab-22A is a protein that in humans is encoded by the RAB22A gene.

Golgin-45 is a protein that in humans is encoded by the BLZF1 gene.

GRIP and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the GCC2 gene.

TATA element modulatory factor is a protein that in humans is encoded by the TMF1 gene.

Ras-related protein Rab-34 is a protein that in humans is encoded by the RAB34 gene.

Protein Hook homolog 3 is a protein that in humans is encoded by the HOOK3 gene.

Golgin subfamily A member 1 is a protein that in humans is encoded by the GOLGA1 gene.

GRIP and coiled-coil domain-containing protein 1 is a protein that in humans is encoded by the GCC1 gene.

Giantin or Golgin subfamily B member 1 is a protein that in humans is encoded by the GOLGB1 gene. Giantin is located at the cis-medial rims of the Golgi apparatus and is part of the Golgi matrix that is responsible for membrane trafficking in secretory pathway of proteins. This function is key for proper localisation of proteins at the plasma membrane and outside the cell which is important for cell function that is dependent on for example receptors and the extracellular matrix function. Recent animal model knockout studies of GOLGB1 in mice, rat, and zebrafish have shown that phenotypes are different between species ranging from mild to severe craniofacial defects in the rodent models to just minor size defects in zebrafish. However, in adult zebrafish a tumoral calcinosis-like phenotype was observed, and in humans such phenotype has been linked to defective glycosyltransferase function.

The Golgi matrix is a collection of proteins involved in the structure and function of the Golgi apparatus. The matrix was first isolated in 1994 as an amorphous collection of 12 proteins that remained associated together in the presence of detergent and 150 mM NaCl. Treatment with a protease enzyme removed the matrix, which confirmed the importance of proteins for the matrix structure. Modern freeze etch electron microscopy (EM) clearly shows a mesh connecting Golgi cisternae and associated vesicles. Further support for the existence of a matrix comes from EM images showing that ribosomes are excluded from regions between and near Golgi cisternae.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000066455 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021192 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ishizaka Y, Ochiai M, Tahira T, Sugimura T, Nagao M (Jul 1989). "Activation of the ret-II oncogene without a sequence encoding a transmembrane domain and transforming activity of two ret-II oncogene products differing in carboxy-termini due to alternative splicing". Oncogene. 4 (6): 789–94. PMID 2734021.
↑ Klugbauer S, Demidchik EP, Lengfelder E, Rabes HM (Feb 1998). "Detection of a novel type of RET rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved RET-fused gene RFG5". Cancer Res. 58 (2): 198–203. PMID 9443391.
↑ Oka T, Ungar D, Hughson FM, Krieger M (Apr 2004). "The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins". Mol Biol Cell. 15 (5): 2423–35. doi:10.1091/mbc.E03-09-0699. PMC 404034 . PMID 15004235.
1 2 "Entrez Gene: GOLGA5 golgi autoantigen, golgin subfamily a, 5".
↑ Satoh, Ayano; Wang Yanzhuang; Malsam Jörg; Beard Matthew B; Warren Graham (Mar 2003). "Golgin-84 is a rab1 binding partner involved in Golgi structure". Traffic. Denmark. 4 (3): 153–61. doi:10.1034/j.1600-0854.2003.00103.x. ISSN 1398-9219. PMC 3282115 . PMID 12656988.
↑ Diao, Aipo; Rahman Dinah; Pappin Darryl J C; Lucocq John; Lowe Martin (Jan 2003). "The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation". J. Cell Biol. United States. 160 (2): 201–12. doi:10.1083/jcb.200207045. ISSN 0021-9525. PMC 2172652 . PMID 12538640.

Short B, Barr FA (2004). "Membrane traffic: a glitch in the Golgi matrix". Curr. Biol. 13 (8): R311–3. doi: 10.1016/S0960982203002343 . PMID 12699642.
Bascom RA, Srinivasan S, Nussbaum RL (1999). "Identification and characterization of golgin-84, a novel Golgi integral membrane protein with a cytoplasmic coiled-coil domain". J. Biol. Chem. 274 (5): 2953–62. doi: 10.1074/jbc.274.5.2953 . PMID 9915833.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi: 10.1038/nature01348 . PMID 12508121.
Diao A, Rahman D, Pappin DJ, et al. (2003). "The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation". J. Cell Biol. 160 (2): 201–12. doi:10.1083/jcb.200207045. PMC 2172652 . PMID 12538640.
Satoh A, Wang Y, Malsam J, et al. (2003). "Golgin-84 is a rab1 binding partner involved in Golgi structure". Traffic. 4 (3): 153–61. doi:10.1034/j.1600-0854.2003.00103.x. PMC 3282115 . PMID 12656988.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Malsam J, Satoh A, Pelletier L, Warren G (2005). "Golgin tethers define subpopulations of COPI vesicles". Science. 307 (5712): 1095–8. Bibcode:2005Sci...307.1095M. doi:10.1126/science.1108061. PMID 15718469. S2CID 12601850.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000066455 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021192 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2734021-5] Ishizaka Y, Ochiai M, Tahira T, Sugimura T, Nagao M (Jul 1989). "Activation of the ret-II oncogene without a sequence encoding a transmembrane domain and transforming activity of two ret-II oncogene products differing in carboxy-termini due to alternative splicing". Oncogene. 4 (6): 789–94. PMID 2734021.

[pmid9443391-6] Klugbauer S, Demidchik EP, Lengfelder E, Rabes HM (Feb 1998). "Detection of a novel type of RET rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved RET-fused gene RFG5". Cancer Res. 58 (2): 198–203. PMID 9443391.

[pmid15004235-7] Oka T, Ungar D, Hughson FM, Krieger M (Apr 2004). "The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins". Mol Biol Cell. 15 (5): 2423–35. doi:10.1091/mbc.E03-09-0699. PMC 404034 . PMID 15004235.

[entrez-8] 1 2 "Entrez Gene: GOLGA5 golgi autoantigen, golgin subfamily a, 5".

[pmid12656988-9] Satoh, Ayano; Wang Yanzhuang; Malsam Jörg; Beard Matthew B; Warren Graham (Mar 2003). "Golgin-84 is a rab1 binding partner involved in Golgi structure". Traffic. Denmark. 4 (3): 153–61. doi:10.1034/j.1600-0854.2003.00103.x. ISSN 1398-9219. PMC 3282115 . PMID 12656988.

[pmid12538640-10] Diao, Aipo; Rahman Dinah; Pappin Darryl J C; Lucocq John; Lowe Martin (Jan 2003). "The coiled-coil membrane protein golgin-84 is a novel rab effector required for Golgi ribbon formation". J. Cell Biol. United States. 160 (2): 201–12. doi:10.1083/jcb.200207045. ISSN 0021-9525. PMC 2172652 . PMID 12538640.

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GOLGA5

Contents

Interactions

Related Research Articles

References

Further reading