GON4L

GON4L
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UG2
Identifiers
Aliases	GON4L , GON-4, GON4, YARP, gon-4 like
External IDs	OMIM: 610393; MGI: 1917579; HomoloGene: 13002; GeneCards: GON4L; OMA:GON4L - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q22 Start 155,749,659 bp [1] End 155,859,400 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F1 Start 88,835,231 bp [2] End 88,910,103 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve granulocyte epithelium of colon buccal mucosa cell Achilles tendon right uterine tube apex of heart anterior pituitary gastric mucosa right lobe of thyroid gland Top expressed in saccule zygote otic vesicle primary oocyte otic placode spermatocyte secondary oocyte neural layer of retina tail of embryo ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription corepressor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm nuclear body nucleus Biological process transcription, DNA-templated regulation of transcription, DNA-templated B cell differentiation negative regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54856 76022 Ensembl ENSG00000116580 ENSMUSG00000054199 UniProt Q3T8J9 Q9DB00 RefSeq (mRNA) NM_001037533 NM_001282856 NM_001282858 NM_001282860 NM_001282861 NM_032292 NM_025174 NM_001242372 NM_027389 RefSeq (protein) NP_001269785 NP_001269787 NP_001269789 NP_001269790 NP_115668 NP_001229301 NP_081665 Location (UCSC) Chr 1: 155.75 – 155.86 Mb Chr 3: 88.84 – 88.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GON-4-like protein is a protein that in humans is encoded by the GON4L gene. ^{[5] [6]} It is a nuclear protein containing two serine phosphosites and a lysine-glutamine cross-link ^[7] and is thought to be a transcription factor. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000116580 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054199 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kuryshev VY, Vorobyov E, Zink D, Schmitz J, Rozhdestvensky TS, Münstermann E, Ernst U, Wellenreuther R, Moosmayer P, Bechtel S, Schupp I, Horst J, Korn B, Poustka A, Wiemann S (August 2006). "An anthropoid-specific segmental duplication on human chromosome 1q22". Genomics. 88 (2): 143–51. doi: 10.1016/j.ygeno.2006.02.002 . PMID   16545939.
6. "Entrez Gene: GON4L gon-4-like (C. elegans)".
7. "Expasy listing: GON4L gon-4-like".
8. Online Mendelian Inheritance in Man (OMIM): GON4L gon-4-like - 610393

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi: 10.1093/dnares/7.4.271 . PMID   10997877.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMC   311072 . PMID   11230166.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (January 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (October 2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, et al. (May 2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.