GP2 (gene)

GP2
Identifiers
Aliases	GP2 , ZAP75, glycoprotein 2
External IDs	OMIM: 602977; MGI: 1914383; HomoloGene: 133790; GeneCards: GP2; OMA:GP2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p12.3 Start 20,309,574 bp [1] End 20,327,808 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 F2|7 63.88 cM Start 119,041,760 bp [2] End 119,058,508 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas islet of Langerhans pancreatic ductal cell gallbladder olfactory zone of nasal mucosa sperm duodenum renal medulla pylorus prostate Top expressed in pyloric antrum trachea islet of Langerhans duodenum conjunctival fornix olfactory epithelium lumbar spinal ganglion right kidney thymus cervix More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 2813 67133 Ensembl ENSG00000169347 ENSMUSG00000030954 UniProt P55259 Q9D733 RefSeq (mRNA) NM_001007240 NM_001007241 NM_001007242 NM_001502 NM_025989 RefSeq (protein) NP_001007241 NP_001007242 NP_001007243 NP_001493 NP_080265 Location (UCSC) Chr 16: 20.31 – 20.33 Mb Chr 7: 119.04 – 119.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Pancreatic secretory granule membrane major glycoprotein GP2 is a protein that in humans is encoded by the GP2 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000169347 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030954 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fukuoka SI, Suzuki M, Okabayashi K, Takahashi E (Jun 1998). "Assignment of pancreatic zymogen granule membrane protein GP2 (GP2) to human chromosome band 9q21.11 to q21.2 by in situ hybridization". Cytogenet Cell Genet. 79 (3–4): 231–2. doi:10.1159/000134730. PMID   9605860.
6. "Entrez Gene: GP2 glycoprotein 2 (zymogen granule membrane)".

Further reading

• Jacob M, Lainé J, LeBel D (1993). "Specific interactions of pancreatic amylase at acidic pH. Amylase and the major protein of the zymogen granule membrane (GP-2) bind to immobilized or polymerized amylase". Biochem. Cell Biol. 70 (10–11): 1105–14. doi:10.1139/o92-156. PMID   1284286.
• Fukuoka S, Freedman SD, Yu H, et al. (1992). "GP-2/THP gene family encodes self-binding glycosylphosphatidylinositol-anchored proteins in apical secretory compartments of pancreas and kidney". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1189–93. Bibcode:1992PNAS...89.1189F. doi: 10.1073/pnas.89.4.1189 . PMC   48414 . PMID   1531535.
• Paul E, Leblond FA, LeBel D (1991). "In resting conditions, the pancreatic granule membrane protein GP-2 is secreted by cleavage of its glycosylphosphatidylinositol anchor". Biochem. J. 277 (3): 879–81. doi:10.1042/bj2770879. PMC   1151326 . PMID   1651706.
• Fukuoka S, Freedman SD, Scheele GA (1991). "A single gene encodes membrane-bound and free forms of GP-2, the major glycoprotein in pancreatic secretory (zymogen) granule membranes". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2898–902. Bibcode:1991PNAS...88.2898F. doi: 10.1073/pnas.88.7.2898 . PMC   51347 . PMID   2011597.
• Rindler MJ, Hoops TC (1991). "The pancreatic membrane protein GP-2 localizes specifically to secretory granules and is shed into the pancreatic juice as a protein aggregate". Eur. J. Cell Biol. 53 (1): 154–63. PMID   2076702.
• Hoops TC, Ivanov I, Cui Z, et al. (1994). "Incorporation of the pancreatic membrane protein GP-2 into secretory granules in exocrine but not endocrine cells". J. Biol. Chem. 268 (34): 25694–705. doi: 10.1016/S0021-9258(19)74445-7 . PMID   7503984.
• Freedman SD, Sakamoto K, Scheele GA (1994). "Nonparallel secretion of GP-2 from exocrine pancreas implies luminal coupling between acinar and duct cells". Am. J. Physiol. 267 (1 Pt 1): G40–51. doi:10.1152/ajpgi.1994.267.1.G40. PMID   7519402.
• Wong SM, Lowe AW (1996). "Sequence of the cDNA encoding human GP-2, the major membrane protein in the secretory granule of the exocrine pancreas". Gene. 171 (2): 311–2. doi: 10.1016/0378-1119(96)00065-0 . PMID   8666297.
• Fukuoka S (2000). "Molecular cloning and sequences of cDNAs encoding alpha (large) and beta (small) isoforms of human pancreatic zymogen granule membrane-associated protein GP2". Biochim. Biophys. Acta. 1491 (1–3): 376–80. doi:10.1016/S0167-4781(00)00057-9. PMID   10760606.
• Parker EM, Zaman MM, Freedman SD (2001). "GP2, a GPI-anchored protein in the apical plasma membrane of the pancreatic acinar cell, co-immunoprecipitates with src kinases and caveolin". Pancreas. 21 (3): 219–25. doi:10.1097/00006676-200010000-00001. PMID   11039464. S2CID   21316326.
• Kalus I, Hodel A, Koch A, et al. (2002). "Interaction of syncollin with GP-2, the major membrane protein of pancreatic zymogen granules, and association with lipid microdomains". Biochem. J. 362 (Pt 2): 433–42. doi:10.1042/0264-6021:3620433. PMC   1222404 . PMID   11853552.
• Tsujii-Hayashi Y, Kitahara M, Yamagaki T, et al. (2003). "A potential endogenous ligand of annexin IV in the exocrine pancreas. Carbohydrate structure of GP-2, a glycosylphosphatidylinositol-anchored glycoprotein of zymogen granule membranes". J. Biol. Chem. 277 (49): 47493–9. doi: 10.1074/jbc.M206572200 . PMID   12324456.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Tamiya G, Shinya M, Imanishi T, et al. (2005). "Whole genome association study of rheumatoid arthritis using 27 039 microsatellites". Hum. Mol. Genet. 14 (16): 2305–21. doi: 10.1093/hmg/ddi234 . PMID   16000323.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Stsiapanava A, Xu C, Nishio S, Han L, Yamakawa N, Carroni M, Tunyasuvunakool K, Jumper J, de Sanctis D, Wu B, Jovine L (2022). "Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH". Nat. Struct. Mol. Biol. 29 (3): 190–193. doi: 10.1038/s41594-022-00729-3 . PMC   8930769 . PMID   35273390. PDB: 7P6R, 7P6S, 7P6T ​