GRAP

GRAP
Identifiers
Aliases	GRAP , GRB2-related adaptor protein, GRB2 related adaptor protein, DFNB114
External IDs	OMIM: 604330; MGI: 1918770; HomoloGene: 4822; GeneCards: GRAP; OMA:GRAP - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p11.2 Start 19,020,656 bp [1] End 19,047,011 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B2 Start 61,544,091 bp [2] End 61,563,610 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen granulocyte lymph node blood right lung upper lobe of left lung gallbladder apex of heart appendix right lobe of thyroid gland Top expressed in mesenteric lymph nodes thymus spleen right lung lobe blood lip subcutaneous adipose tissue embryo left lung lobe right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding non-membrane spanning protein tyrosine kinase activity signaling receptor binding Cellular component cytoplasm cytosol extrinsic component of cytoplasmic side of plasma membrane Biological process cell-cell signaling Ras protein signal transduction positive regulation of signal transduction transmembrane receptor protein tyrosine kinase signaling pathway cell migration cell differentiation peptidyl-tyrosine autophosphorylation regulation of cell population proliferation innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10750 71520 Ensembl ENSG00000154016 ENSMUSG00000004837 UniProt Q13588 Q9CX99 RefSeq (mRNA) NM_006613 NM_001330148 NM_027817 RefSeq (protein) NP_001317077 NP_006604 NP_082093 Location (UCSC) Chr 17: 19.02 – 19.05 Mb Chr 11: 61.54 – 61.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GRB2-related adapter protein is a protein that in humans is encoded by the GRAP gene. ^{[5] [6] [7]}

This gene encodes a member of the GRB2/Sem5 ( C. elegans homolog)/Drk ( Drosophila homolog) family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. ^[7]

Interactions

GRAP has been shown to interact with Linker of activated T cells. ^{[8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000154016 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004837 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (May 1996). "Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway". The Journal of Biological Chemistry. 271 (21): 12129–32. doi: 10.1074/jbc.271.21.12129 . PMID   8647802.
6. Trüb T, Frantz JD, Miyazaki M, Band H, Shoelson SE (Jan 1997). "The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling". The Journal of Biological Chemistry. 272 (2): 894–902. doi: 10.1074/jbc.272.2.894 . PMID   8995379.
7. "Entrez Gene: GRAP GRB2-related adaptor protein".
8. Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE (Jan 1998). "LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation". Cell. 92 (1): 83–92. doi: 10.1016/S0092-8674(00)80901-0 . PMID   9489702. S2CID   1806525.
9. Perez-Villar JJ, Whitney GS, Sitnick MT, Dunn RJ, Venkatesan S, O'Day K, Schieven GL, Lin TA, Kanner SB (Aug 2002). "Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav". Biochemistry. 41 (34): 10732–40. doi:10.1021/bi025554o. PMID   12186560.

Further reading

• Welsh M, Songyang Z, Frantz JD, Trüb T, Reedquist KA, Karlsson T, Miyazaki M, Cantley LC, Band H, Shoelson SE (Feb 1998). "Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins". Oncogene. 16 (7): 891–901. doi:10.1038/sj.onc.1201607. PMID   9484780. S2CID   28452652.
• Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE (Jan 1998). "LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation". Cell. 92 (1): 83–92. doi: 10.1016/S0092-8674(00)80901-0 . PMID   9489702. S2CID   1806525.
• Wenzel J, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan DR, Kabelitz D, Feller SM, Janssen O (Dec 2001). "Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor". FEBS Letters. 509 (2): 255–62. doi:10.1016/S0014-5793(01)03174-X. PMID   11741599. S2CID   33084576.
• Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS (Sep 2003). "GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2". The Journal of Biological Chemistry. 278 (36): 34641–53. doi: 10.1074/jbc.M304594200 . PMID   12819203.
• Shiraiwa H, Takei M, Yoshikawa T, Azuma T, Kato M, Mitamura K, Ueki T, Kida A, Horie T, Seki N, Sawada S (2004). "Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjögren's syndrome". The Journal of International Medical Research. 32 (3): 284–91. doi: 10.1177/147323000403200308 . PMID   15174222.