GZMH

GZMH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3TJU, 3TJV, 3TK9, 4GAW
Identifiers
Aliases	GZMH , CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2, granzyme H
External IDs	OMIM: 116831 MGI: 109254 HomoloGene: 133275 GeneCards: GZMH
Gene location (Human)
Chr.	Chromosome 14 (human)
End	24,609,699 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	56,448,874 bp
RNA expression pattern
	Top expressed in
	blood; ; spleen; ; bone marrow cells; ; periodontal fiber; ; gallbladder; ; lymph node; ; right lung; ; palpebral conjunctiva; ; monocyte; ; upper lobe of left lung;
	Top expressed in
	Ankle joint; ; uterus; ; yolk sac; ; adipose tissue; ; dentate gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity ; serine-type peptidase activity ; serine-type endopeptidase activity ; hydrolase activity ;
Cellular component	membrane ; secretory granule ; cytoplasm ;
Biological process	cytolysis ; apoptotic process ; proteolysis ; granzyme-mediated apoptotic signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	2999
	14943
	ENSG00000100450
	ENSMUSG00000015441
	P20718
	P08883
	NM_001270780 ; NM_001270781 ; NM_033423
	NM_010374
	NP_001257709 ; NP_001257710 ; NP_219491
	NP_034504
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 17, 2022

Granzyme H is a protein that in humans is encoded by the GZMH gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100450 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015441 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Haddad P, Jenne D, Tschopp J, Clement MV, Mathieu-Mahul D, Sasportes M (Jul 1991). "Structure and evolutionary origin of the human granzyme H gene" (PDF). Int Immunol. 3 (1): 57–66. doi:10.1093/intimm/3.1.57. PMID 2049336.
↑ "Entrez Gene: GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)".

Waterhouse NJ, Trapani JA (2007). "H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells". Trends Immunol. 28 (9): 373–5. doi:10.1016/j.it.2007.08.001. PMID 17766182.
Llorens C, Martres MP, Baudry M, Schwartz JC (1978). "Hypersensitivity to noradrenaline in cortex after chronic morphine: relevance to tolerance and dependence". Nature. 274 (5671): 603–5. Bibcode:1978Natur.274..603L. doi:10.1038/274603a0. PMID 209336. S2CID 4293645.
Heusel JW, Hanson RD, Silverman GA, Ley TJ (1991). "Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2". J. Biol. Chem. 266 (10): 6152–8. doi: 10.1016/S0021-9258(18)38097-9 . PMID 2007574.
Meier M, Kwong PC, Frégeau CJ, et al. (1990). "Cloning of a gene that encodes a new member of the human cytotoxic cell protease family". Biochemistry. 29 (17): 4042–9. doi:10.1021/bi00469a003. PMID 2193684.
Hanson RD, Hohn PA, Popescu NC, Ley TJ (1990). "A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus". Proc. Natl. Acad. Sci. U.S.A. 87 (3): 960–3. Bibcode:1990PNAS...87..960H. doi: 10.1073/pnas.87.3.960 . PMC 53389 . PMID 2300587.
Klein JL, Selvakumar A, Trapani JA, Dupont B (1990). "Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C)". Tissue Antigens. 35 (5): 220–8. doi:10.1111/j.1399-0039.1990.tb01787.x. PMID 2402757.
MacIvor DM, Pham CT, Ley TJ (1999). "The 5' flanking region of the human granzyme H gene directs expression to T/natural killer cell progenitors and lymphokine-activated killer cells in transgenic mice". Blood. 93 (3): 963–73. doi:10.1182/blood.V93.3.963. PMID 9920846.
Edwards KM, Kam CM, Powers JC, Trapani JA (1999). "The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes". J. Biol. Chem. 274 (43): 30468–73. doi: 10.1074/jbc.274.43.30468 . PMID 10521426.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Johnson H, Scorrano L, Korsmeyer SJ, Ley TJ (2003). "Cell death induced by granzyme C". Blood. 101 (8): 3093–101. doi: 10.1182/blood-2002-08-2485 . PMID 12515723.
Sedelies KA, Sayers TJ, Edwards KM, et al. (2004). "Discordant regulation of granzyme H and granzyme B expression in human lymphocytes". J. Biol. Chem. 279 (25): 26581–7. doi: 10.1074/jbc.M312481200 . PMID 15069086.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Andrade F, Fellows E, Jenne DE, et al. (2007). "Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition". EMBO J. 26 (8): 2148–57. doi:10.1038/sj.emboj.7601650. PMC 1852776 . PMID 17363894.
Fellows E, Gil-Parrado S, Jenne DE, Kurschus FC (2007). "Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program". Blood. 110 (2): 544–52. doi: 10.1182/blood-2006-10-051649 . PMID 17409270.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000100450 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015441 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2049336-5] Haddad P, Jenne D, Tschopp J, Clement MV, Mathieu-Mahul D, Sasportes M (Jul 1991). "Structure and evolutionary origin of the human granzyme H gene" (PDF). Int Immunol. 3 (1): 57–66. doi:10.1093/intimm/3.1.57. PMID 2049336.

[entrez-6] "Entrez Gene: GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)".

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GZMH

Related Research Articles

References

Further reading