Galectin-7

LGALS7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UW5, 2GAL, 4GAL, 1BKZ, 4UW4, 3ZXE, 3GAL, 3ZXF, 4UW6, 4XBQ, 5GAL, 4UW3, 5H9S, 4Y26, 5H9Q
Identifiers
Aliases	LGALS7 , GAL7, LGALS7A, galectin 7
External IDs	OMIM: 600615 MGI: 1316742 HomoloGene: 100509 GeneCards: LGALS7
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.2 Start 38,770,968 bp [1] End 38,773,517 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 B1 Start 28,563,278 bp [2] End 28,565,709 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen vagina minor salivary gland right lung spleen gastric mucosa thymus fundus gastrocnemius muscle left lobe of thyroid gland Top expressed in lip esophagus superior surface of tongue skin of abdomen skin of back belly cord epidermis hair follicle condyle fossa More reference expression data BioGPS n/a
Gene ontology Molecular function carbohydrate binding Cellular component cytoplasm extracellular region extracellular exosome nucleus extracellular space Biological process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3963 16858 Ensembl ENSG00000283082 ENSG00000205076 ENSMUSG00000053522 UniProt P47929 O54974 RefSeq (mRNA) NM_002307 NM_008496 RefSeq (protein) NP_002298 NP_001035972 n/a Location (UCSC) Chr 19: 38.77 – 38.77 Mb Chr 7: 28.56 – 28.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Galectin-7 is a protein that in humans is encoded by the LGALS7 gene. ^{[5] [6] [7]}

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell–cell and cell–matrix interactions. Differential and in situ hybridizations indicate that this lectin is specifically expressed in keratinocytes. It is expressed at all stages of epidermal differentiation (i.e., in basal and suprabasal layers). It is moderately repressed by retinoic acid. The protein was found mainly in stratified squamous epithelium. The antigen localized to basal keratinocytes, although it was also found, albeit at lower levels, in the suprabasal layers where it concentrated to areas of cell-to-cell contact. The cellular localization and its striking down-regulation in cultured keratinocytes imply a role in cell–cell and/or cell–matrix interactions necessary for normal growth control. ^[7]

References

1. ENSG00000205076 GRCh38: Ensembl release 89: ENSG00000283082, ENSG00000205076 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053522 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Madsen P, Rasmussen HH, Flint T, Gromov P, Kruse TA, Honore B, Vorum H, Celis JE (Apr 1995). "Cloning, expression, and chromosome mapping of human galectin-7". J Biol Chem. 270 (11): 5823–29. doi: 10.1074/jbc.270.11.5823 . PMID   7534301.
6. Magnaldo T, Bernerd F, Darmon M (May 1995). "Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid". Dev Biol. 168 (2): 259–71. doi: 10.1006/dbio.1995.1078 . PMID   7729568.
7. "Entrez Gene: LGALS7 lectin, galactoside-binding, soluble, 7 (galectin 7)".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Polyak K, Xia Y, Zweier JL, et al. (1997). "A model for p53-induced apoptosis". Nature. 389 (6648): 300–5. Bibcode:1997Natur.389..300P. doi:10.1038/38525. PMID   9305847. S2CID   4429638.
• Magnaldo T, Fowlis D, Darmon M (1998). "Galectin-7, a marker of all types of stratified epithelia". Differentiation. 63 (3): 159–68. doi:10.1046/j.1432-0436.1998.6330159.x. PMID   9697310.
• Leonidas DD, Vatzaki EH, Vorum H, et al. (1998). "Structural basis for the recognition of carbohydrates by human galectin-7". Biochemistry. 37 (40): 13930–40. doi:10.1021/bi981056x. PMID   9760227. S2CID   27458839.
• Bernerd F, Sarasin A, Magnaldo T (1999). "Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11329–34. Bibcode:1999PNAS...9611329B. doi: 10.1073/pnas.96.20.11329 . PMC   18033 . PMID   10500176.
• Kuwabara I, Kuwabara Y, Yang RY, et al. (2002). "Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release". J. Biol. Chem. 277 (5): 3487–97. doi: 10.1074/jbc.M109360200 . PMID   11706006.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Cao Z, Said N, Wu HK, et al. (2003). "Galectin-7 as a potential mediator of corneal epithelial cell migration". Arch. Ophthalmol. 121 (1): 82–6. doi:10.1001/archopht.121.1.82. PMID   12523890.
• Kopitz J, André S, von Reitzenstein C, et al. (2003). "Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells". Oncogene. 22 (40): 6277–88. doi: 10.1038/sj.onc.1206631 . PMID   13679866.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Saussez S, Cucu DR, Decaestecker C, et al. (2006). "Galectin 7 (p53-induced gene 1): a new prognostic predictor of recurrence and survival in stage IV hypopharyngeal cancer". Ann. Surg. Oncol. 13 (7): 999–1009. doi:10.1245/ASO.2006.08.033. PMID   16788763. S2CID   12521102.