Gamma-glutamyltransferase 6

GGT6
Identifiers
Aliases	GGT6 , gamma-glutamyltransferase 6
External IDs	OMIM: 612341 MGI: 1918772 HomoloGene: 51918 GeneCards: GGT6
EC number	3.4.19.13
Gene location (Human)
Chr.	Chromosome 17 (human)
End	4,560,818 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	72,329,226 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; parotid gland; ; skin of abdomen; ; rectum; ; body of pancreas; ; kidney; ; duodenum; ; minor salivary gland; ; renal medulla; ; vulva;
	Top expressed in
	lip; ; left colon; ; Paneth cell; ; esophagus; ; jejunum; ; left lobe of liver; ; ileum; ; proximal tubule; ; duodenum; ; skin of abdomen;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; glutathione hydrolase activity ; acyltransferase activity ; hydrolase activity ; hypoglycin A gamma-glutamyl transpeptidase activity ; molecular function ; leukotriene C4 gamma-glutamyl transferase activity ;
Cellular component	integral component of membrane ; extracellular exosome ; membrane ;
Biological process	glutathione biosynthetic process ; proteolysis ; glutathione catabolic process ; glutathione metabolic process ; leukotriene D4 biosynthetic process ; biological process ;
	Sources:Amigo / QuickGO
Orthologs
	124975
	71522
	ENSG00000167741
	ENSMUSG00000040471
	Q6P531
	Q6PDE7
	NM_153338 ; NM_001122890 ; NM_001288702 ; NM_001288703 ; NM_001288704 Contents Function ; References ; Further reading ;
	NM_027819
	NP_001116362 ; NP_001275631 ; NP_001275632 ; NP_001275633 ; NP_699169
	NP_082095
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Gamma-glutamyltransferase 6 is a protein that in humans is encoded by the GGT6 gene. ^[5]

Function

GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).

Related Research Articles

Gamma-glutamyltransferase is a transferase that catalyzes the transfer of gamma-glutamyl functional groups from molecules such as glutathione to an acceptor that may be an amino acid, a peptide or water. GGT plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione as well as drug and xenobiotic detoxification. Other lines of evidence indicate that GGT can also exert a pro-oxidant role, with regulatory effects at various levels in cellular signal transduction and cellular pathophysiology. This transferase is found in many tissues, the most notable one being the liver, and has significance in medicine as a diagnostic marker.

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Ghk.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000167741 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040471 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Gamma-glutamyltransferase 6" . Retrieved 2016-03-11.

Gamma-glutamyltransferase 6

Contents

Function

Related Research Articles

References

Further reading