Garret A. FitzGerald

Last updated

Garret FitzGerald
MRIA FRS
Born
Garret Adare FitzGerald

(1950-05-11) 11 May 1950 (age 74)
Greystones, County Wicklow [1]
NationalityRepublic of Ireland
Education Belvedere College [2]
Alma mater University College Dublin (MB BCh, MD)
Trinity College Dublin (PgD)
University of London (MSc) [3]
Awards Cameron Prize for Therapeutics of the University of Edinburgh (2007)
Scientific career
Fields Circadian rhythms
Cardiology
Vascular biology
Molecular clocks
Pharmacology [4]
Institutions Vanderbilt University (1980–1991)
University College, Dublin (1991–1994)
University of Pennsylvania (1994–)
Website www.med.upenn.edu/fitzgeraldlab/personnel.html

Garret Adare FitzGerald MRIA FRS is an Irish physician. He is professor of translational medicine and Therapeutics and chair of the department of pharmacology at the Perelman School of Medicine of the University of Pennsylvania. [5] He researches aspects of cardiology, pharmacology, translational medicine, and chronobiology. [4]

Contents

Early life and education

FitzGerald was born in Greystones, County Wicklow, on 11 May 1950. [1] He grew up in Dublin, [3] acquiring an unabated passion for rugby. [6] He attended Belvedere College, a Jesuit school for boys in Dublin. [2] Influenced by his grandfather, who had been a professor of Greek, FitzGerald learned five languages at school including Greek and Latin. [1] FitzGerald went to study medicine at University College Dublin (UCD), where he received an MB BCh (honours) degree in 1974 and an MD degree in 1980. In between, he also obtained a Postgraduate diploma in statistics from Trinity College Dublin in 1977 and an MSc degree in statistics at the London School of Hygiene and Tropical Medicine in 1979. [3] [5]

FitzGerald attributes his career in medicine to "a series of accidents". [1] During his final examinations at UCD he was required to dissect the mouthparts of a cockroach. Peering through a microscope, FitzGerald discovered that he had lost one of the main pieces. Disaster seemed certain as he searched the floor on his hands and knees. The exam proctor came to help and eventually emerged with the tiny fragment stuck to her thumb. FitzGerald has stated that without her intervention he would never have become a physician. [3]

Career

After completing his clinical training, FitzGerald took a research position at Vanderbilt University in 1980. He returned to Ireland in 1991 before relocating to the University of Pennsylvania in 1994 as the founding director of the Center for Experimental Therapeutics (CET). He became chair of pharmacology in 1996. [6]

FitzGerald was a member of the Science Board to the US Food and Drug Administration (FDA). [7]

FitzGerald's work contributed substantially to the development of low-dose aspirin to prevent heart attacks and strokes. [3] FitzGerald's lab was the first to predict and then mechanistically explain the cardiovascular hazard from Nonsteroidal anti-inflammatory drugs (NSAIDs), a common class of painkiller. [8] His work showing that selective COX-2 inhibitors depress the production of prostacyclin in the endothelium, thereby increasing cardiovascular risk, [9] was instrumental in the withdrawal of Vioxx (rofecoxib) from the U.S. market in 2004. [3] [10]

Honours and awards

FitzGerald is a member of the National Academy of Medicine, the American Academy of Arts and Sciences, the Royal Society, the Accademia dei Lincei and the Leopoldina, and an honorary member of the Royal Irish Academy.

Related Research Articles

<span class="mw-page-title-main">Garret FitzGerald</span> 8th Taoiseach from 1981–1982, 1982–1987

Garret Desmond FitzGerald was an Irish Fine Gael politician, public intellectual, economist and barrister who served twice as Taoiseach, serving from 1981 to 1982 and 1982 to 1987. He served as Leader of Fine Gael from 1977 to 1987 and was twice Leader of the Opposition between 1977 and 1982; he was previously Minister for Foreign Affairs from 1973 to 1977. FitzGerald served as a Teachta Dála (TD) from 1969 to 1992 and was a Senator for the Industrial and Commercial Panel from 1965 to 1969.

Niall FitzGerald is an Irish businessman.

James Clement Dooge was an Irish Fine Gael politician, engineer, climatologist, hydrologist and academic who served as Minister for Foreign Affairs from 1981 to 1982, Leader of the Seanad and Leader of Fine Gael in the Seanad from 1982 to 1987 and Cathaoirleach of Seanad Éireann from 1973 to 1977. He served as a Senator from 1961 to 1977 and 1981 to 1987.

<span class="mw-page-title-main">James Black (pharmacologist)</span> Scottish doctor and pharmacologist (1924–2010)

Sir James Whyte Black was a Scottish physician and pharmacologist. Together with Gertrude B. Elion and George H. Hitchings, he shared the Nobel Prize for Medicine in 1988 for pioneering strategies for rational drug-design, which, in his case, lead to the development of propranolol and cimetidine. Black established a Veterinary Physiology department at the University of Glasgow, where he became interested in the effects of adrenaline on the human heart. He went to work for ICI Pharmaceuticals in 1958 and, while there, developed propranolol, a beta blocker used for the treatment of heart disease. Black was also responsible for the development of cimetidine, an H2 receptor antagonist, a drug used to treat stomach ulcers.

<span class="mw-page-title-main">Desmond FitzGerald (politician)</span> Irish revolutionary and politician (1888–1947)

Desmond FitzGerald was an Irish revolutionary, poet, publicist and Fine Gael politician who served as Minister for Defence from 1927 to 1932, Minister for External Affairs from 1922 to 1927, Minister for Publicity from 1921 to 1922 and Director of Publicity from 1919 to 1921. He served as a Teachta Dála (TD) from 1918 to 1937. He was a Senator for the Administrative Panel from 1938 to 1943.

John James Boland was an Irish Fine Gael politician who served as Minister for Health from January 1987 to March 1987, Minister for the Environment from 1986 to 1987, Minister for the Public Service from 1982 to 1986 and Minister for Education from 1981 to 1982. He served as a Teachta Dála (TD) from 1977 to 1989. He also served as a Senator for the Labour Panel from 1969 to 1977.

<span class="mw-page-title-main">Royal College of Surgeons in Ireland</span> Irish medical professional training body and higher education institution

The Royal College of Surgeons in Ireland (RCSI) is a not-for-profit medical professional and educational institution, which is also known as RCSI University of Medicine and Health Sciences. It was established in 1784 as the national body for the surgical branch of medicine in Ireland, with a role in supervision of training, and as of 2021 provides a broad range of medical education in multiple countries.

<span class="mw-page-title-main">UCD School of Medicine</span>

The UCD School of Medicine at University College Dublin, Ireland, was founded in 1854. At undergraduate level, the school offers programmes in Medicine MB BCh BAO, BSc Biomedical Health and Life Sciences, and the BSc Radiography. At graduate level, the school UCD offers over 40 programmes for health care professionals.

Hugh Redmond Brady is an Irish academic, the 17th President of Imperial College London, and a professor of medicine. He was the 13th President and Vice-Chancellor of the University of Bristol. He is also President Emeritus of University College, Dublin (UCD), having served as UCD's eighth President from 2004 to 2013.

<span class="mw-page-title-main">V. Craig Jordan</span> American/British pharmacologist (born 1947)

Virgil Craig Jordan,, is a scientist with American and British citizenship specializing in drugs for breast cancer treatment and prevention. Currently, he is Professor of Breast Medical Oncology, and Professor of Molecular and Cellular Oncology at the University of Texas MD Anderson Cancer Center, Houston, Texas. Previously, he was Scientific Director and Vice Chairman of Oncology at the Lombardi Comprehensive Cancer Center of Georgetown University. Jordan was the first to discover the breast cancer prevention properties of tamoxifen and the scientific principles for adjuvant therapy with antihormones. More recently his work has branched out into the prevention of multiple diseases in women with the discovery of the drug group, selective estrogen receptor modulator (SERMs). Currently, he plans to develop a new Hormone Replacement Therapy (HRT) for post-menopausal women that prevents breast cancer and does not increase the risk of breast cancer.

<span class="mw-page-title-main">British Pharmacological Society</span> British society of pharmacologists

The British Pharmacological Society is the primary UK learned society for pharmacologists, concerned with research into drugs and the ways in which they work. Members work in academia, industry, regulatory agencies, and the health services, and many are medically qualified. The Society covers the whole spectrum of pharmacology, including laboratory, clinical, and toxicological aspects.

Donald Robert James Singer was a British clinical pharmacologist who was the president of the Fellowship of Postgraduate Medicine.

<span class="mw-page-title-main">University College Dublin</span> Public research university in Ireland

University College Dublin is a public research university in Dublin, Ireland, and a member institution of the National University of Ireland. With 38,417 students, it is Ireland's largest university, and amongst the most prestigious universities in Europe. Five Nobel Laureates are among UCD's alumni and current and former staff. Additionally, four Taoisigh and three Irish Presidents have graduated from UCD, along with one President of India.

Emmanuel Ciprian Amoroso, CBE, FRCS, FRCOG, FRCP, FRCPath, FRS, was a Trinidadian reproductive physiologist and developmental biologist with an interest in placenta physiology. Initially studying medicine in Ireland in the 1920s, he was subsequently based in Britain for the rest of his life. He was the first person from the West Indies to be elected as a Fellow of the Royal Society, in 1957, and he had the distinction of being a Fellow of four of the Royal Colleges: Surgeons in 1960, Obstetricians and Gynaecologists in 1965, Physicians in 1966, and Pathologists in 1973.

The Cameron Prize for Therapeutics of the University of Edinburgh is awarded by the College of Medicine and Veterinary Medicine to a person who has made any highly important and valuable addition to practical therapeutics in the previous five years. The prize, which may be awarded biennially, was founded in 1878 by Andrew Robertson Cameron of Richmond, New South Wales, with a sum of £2,000. The University's senatus academicus may require the prizewinner to deliver one or more lectures or to publish an account on the addition made to practical therapeutics. A list of recipients of the prize dates back to 1879.

Annie Curtis is an Irish immunologist at the Royal College of Surgeons in Ireland whose career has spanned academia, public sector and industry. She studies how the power of the body clock can be harnessed to control inflammatory diseases.

<span class="mw-page-title-main">Béla Merkely</span> Hungarian cardiologist (born 1966)

Dr. Béla Merkely is a Hungarian interventional cardiologist and sports cardiologist, a university professor, director of Semmelweis University's Heart and Vascular Centre and the current rector of Semmelweis University since 1 July 2018.

<span class="mw-page-title-main">Drew Weissman</span> American physician and immunologist (born 1959)

Drew Weissman is an American physician and immunologist known for his contributions to RNA biology. Weissman is the inaugural Roberts Family Professor in Vaccine Research, director of the Penn Institute for RNA Innovation, and professor of medicine at the Perelman School of Medicine at the University of Pennsylvania (Penn).

<span class="mw-page-title-main">Daniel P. Kelly</span> American physician

Daniel P. Kelly is Director of the Penn[1][2] and CHOP[3][4] Cardiovascular Institutes (CVI) and the Willard and Rhoda Ware Professor of Diabetes and Metabolic Diseases at the University of Pennsylvania Perelman School of Medicine and the Rachel Ash Presidential Professor at Children’s Hospital of Philadelphia (CHOP). He is a cardiologist and physician-scientist recognized for his contributions to the transcriptional control of mitochondrial function and the metabolic origins of heart disease.

Denis J. Coffey was an Irish Professor of Physiology at the Catholic University Medical School, Dean of Medicine at UCD, and served as president of University College Dublin from 1910 until 1940.

References

  1. 1 2 3 4 Farley, Adam (6 May 2017). "Dr. Garret FitzGerald Wants to Build Bridges". Irish America. No. August/September 2014. Retrieved 26 September 2018.
  2. 1 2 Anon (2017). "FitzGerald, Prof. Garret Adare" . Who's Who (online Oxford University Press  ed.). Oxford: A & C Black. doi:10.1093/ww/9780199540884.013.U281224.(Subscription or UK public library membership required.)
  3. 1 2 3 4 5 6 7 Landau, Elizabeth (21 June 2013). "Doctor is pain medicine 'visionary'". CNN. Retrieved 12 August 2018.
  4. 1 2 Garret A. FitzGerald publications indexed by Google Scholar OOjs UI icon edit-ltr-progressive.svg
  5. 1 2 3 4 5 6 Garret A. FitzGerald, M.D., FRS – website of the Perelman School of Medicine
  6. 1 2 Conner, Kristine. "A man of many parts". Penn Medicine. No. Spring 2001. pp. 6–11. Retrieved 26 September 2018.
  7. ↑ "FDA Science Board Members". US Food and Drug Administration. 31 March 2009. Retrieved 12 August 2018.
  8. ↑ "The FitzGerald Lab – Perelman School of Medicine at the University of Pennsylvania". Personnel. Retrieved 12 August 2018.
  9. ↑ Grosser, Tilo; Fries, Susanne; FitzGerald, Garret A. (8 December 2005). "Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities". Journal of Clinical Investigation. 116 (1). American Society for Clinical Investigation: 4–15. doi:10.1172/jci27291. ISSN   0021-9738. PMC   1323269 . PMID   16395396.
  10. 1 2 "Dubliner receives Boyle Medal for Scientific Excellence". The Irish Times. 20 October 2005. Retrieved 25 August 2018.
  11. ↑ "Previous Recipients". Robarts Research. 25 July 2018. Archived from the original on 13 August 2018. Retrieved 12 August 2018.
  12. ↑ "Jakob-Herz-Preis 2011" (PDF) (in German). Friedrich-Alexander-Universität Erlang-Nürnberg. 5 February 2011. Retrieved 13 August 2018.
  13. ↑ Anon (2012). "Garret FitzGerald". royalsociety.org. Retrieved 12 August 2018.
  14. ↑ Genest, Jacques; Hébert, Terence E.; Martin, James (13 October 2016). "The Louis and Artur Lucian Award in Cardiovascular Diseases at McGill University". Circulation Research. 119 (9). Ovid Technologies (Wolters Kluwer Health): 975–977. doi: 10.1161/circresaha.116.309972 . ISSN   0009-7330. PMID   27737939.
  15. ↑ "Former Laureates". Apotekarsocieteten. Archived from the original on 1 December 2017. Retrieved 29 November 2016.
  16. ↑ "The Schottenstein Prize in Cardiovascular Sciences". Ohio State Heart and Vascular Research. Retrieved 12 August 2018.
  17. ↑ "UCD Alumni Awardee".
  18. ↑ "Penn Medicines Garret FitzGerald MD FRS Elected to the German National Academy of Sciences – PR News". Penn Medicine. 7 June 2018. Retrieved 12 August 2018.
  19. ↑ RCSI celebrates graduates at summer conferring ceremonies – website of the Royal College of Surgeons in Ireland
  20. ↑ "Honorary Awards to Foreign Nationals in 2021". Gov.UK. 2021.

Creative Commons by small.svg  This article incorporates text available under the CC BY 4.0 license.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.