Gsk3b interacting protein

Last updated
GSKIP
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GSKIP , C14orf129, HSPC210, GSK3B interacting protein
External IDs OMIM: 616605 MGI: 1914037 HomoloGene: 9522 GeneCards: GSKIP
Gene location (Human)
Ideogram human chromosome 14.svg
Chr. Chromosome 14 (human) [1]
Human chromosome 14 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 14q32.2Start96,363,452 bp [1]
End96,387,288 bp [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016472
NM_001271904
NM_001271905
NM_001271906

NM_178613

RefSeq (protein)

NP_001258833
NP_001258834
NP_001258835
NP_057556

NP_848728

Location (UCSC) Chr 14: 96.36 – 96.39 Mb Chr 12: 105.68 – 105.7 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GSK3B interacting protein is a protein that in humans is encoded by the GSKIP gene. [5]

Contents

Function

This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene.

Related Research Articles

Adenomatous polyposis coli protein-coding gene in the species Homo sapiens

Adenomatous polyposis coli (APC) also known as deleted in polyposis 2.5 (DP2.5) is a protein that in humans is encoded by the APC gene. The APC protein is a negative regulator that controls beta-catenin concentrations and interacts with E-cadherin, which are involved in cell adhesion. Mutations in the APC gene may result in colorectal cancer.

Frzb is a Wnt-binding protein especially important in embryonic development. It is a competitor for the cell-surface G-protein receptor Frizzled.

Beta-catenin mammalian protein found in Homo sapiens

Catenin beta-1, also known as β-catenin, is a protein that in humans is encoded by the CTNNB1 gene.

CTNNBIP1 protein-coding gene in the species Homo sapiens

Beta-catenin-interacting protein 1 is a protein that is encoded in humans by the CTNNBIP1 gene.

GSK3B protein-coding gene in the species Homo sapiens

Glycogen synthase kinase 3 beta, also known as GSK3B, is an enzyme that in humans is encoded by the GSK3B gene. In mice, the enzyme is encoded by the GSK-3β gene. Abnormal regulation and expression of GSK3β is associated with an increased susceptibility towards bipolar disorder.

AXIN1 protein-coding gene in the species Homo sapiens

Axin-1 is a protein that in humans is encoded by the AXIN1 gene.

CEBPA protein-coding gene in the species Homo sapiens

CCAAT/enhancer-binding protein alpha is a protein encoded by the CEBPA gene in humans. CCAAT/enhancer-binding protein alpha is a transcription factor involved in the differentiation of certain blood cells. For details on the CCAAT structural motif in gene enhancers and on CCAAT/Enhancer Binding Proteins see the specific page.

FZD10 protein-coding gene in the species Homo sapiens

Frizzled-10 is a protein that in humans is encoded by the FZD10 gene. FZD10 has also been designated as CD350.

DVL1 protein-coding gene in the species Homo sapiens

Segment polarity protein dishevelled homolog DVL-1 is a protein that in humans is encoded by the DVL1 gene.

MACF1 protein-coding gene in the species Homo sapiens

Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 is a protein that in humans is encoded by the MACF1 gene.

Ninein protein-coding gene in the species Homo sapiens

Ninein is a protein that in humans is encoded by the NIN gene. Ninein, together with its paralog Ninein-like protein is one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported.

AXIN2 protein-coding gene in the species Homo sapiens

Axin-2 also known as axin-like protein (Axil) or axis inhibition protein 2 (AXIN2) or conductin is a protein that in humans is encoded by the AXIN2 gene.

ZBTB33 protein-coding gene in the species Homo sapiens

Transcriptional regulator Kaiso is a protein that in humans is encoded by the ZBTB33 gene. This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2, which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.

MAP3K4 protein-coding gene in the species Homo sapiens

Mitogen-activated protein kinase kinase kinase 4 is an enzyme that in humans is encoded by the MAP3K4 gene.

FRAT1 protein-coding gene in the species Homo sapiens

Proto-oncogene FRAT1 is a protein that in humans is encoded by the FRAT1 gene.

FRAT2 protein-coding gene in the species Homo sapiens

GSK-3-binding protein FRAT2 is a protein that in humans is encoded by the FRAT2 gene.

ILKAP protein-coding gene in the species Homo sapiens

Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene.

Casein kinase 1, alpha 1 protein-coding gene in the species Homo sapiens

Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene.

Dishevelled protein family

Dishevelled (Dsh) is a family of proteins involved in canonical and non-canonical Wnt signalling pathways. Dsh is a cytoplasmic phosphoprotein that acts directly downstream of frizzled receptors. It takes its name from its initial discovery in flies, where a mutation in the dishevelled gene was observed to cause improper orientation of body and wing hairs. There are vertebrate homologs in zebrafish, Xenopus (Xdsh), mice and humans. Dsh relays complex Wnt signals in tissues and cells, in normal and abnormal contexts. It is thought to interact with the novel protein, SPATS1, when regulating the Wnt Signalling pathway.

ZBED3 protein-coding gene in the species Homo sapiens

Zinc finger BED domain-containing protein 3 also known as axin-interacting protein is a protein in humans that is encoded by the ZBED3 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100744 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044715 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: GSK3B interacting protein" . Retrieved 2016-12-05.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.