HEBP2

HEBP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3R85, 3R8J, 3R8K, 4AYZ, 4B0Y
Identifiers
Aliases	HEBP2 , C6ORF34B, C6orf34, PP23, SOUL, heme binding protein 2
External IDs	OMIM: 605825 MGI: 1860084 HomoloGene: 8634 GeneCards: HEBP2
Gene location (Human)
Chr.	Chromosome 6 (human)
End	138,422,197 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	18,421,824 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; amniotic fluid; ; gums; ; vulva; ; right ventricle; ; adipose tissue; ; cavity of mouth; ; abdominal fat; ; triceps brachii muscle; ; subcutaneous adipose tissue;
	Top expressed in
	facial motor nucleus; ; esophagus; ; skin of abdomen; ; lip; ; motor neuron; ; conjunctival fornix; ; cornea; ; condyle; ; skin of back; ; epidermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; heme binding ;
Cellular component	cytoplasm ; extracellular exosome ; mitochondrion ; extracellular region ; azurophil granule lumen ;
Biological process	negative regulation of mitochondrial membrane potential ; positive regulation of necrotic cell death ; regulation of response to reactive oxygen species ; positive regulation of mitochondrial membrane permeability ; neutrophil degranulation ;
	Sources:Amigo / QuickGO
Orthologs
	23593
	56016
	ENSG00000051620
	ENSMUSG00000019853
	Q9Y5Z4
	Q9WU63
	NM_014320 ; NM_001326380 ; NM_001326381
	NM_019487
	NP_001313309 ; NP_001313310 ; NP_055135
	NP_062360
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Heme-binding protein 2 is a protein that in humans is encoded by the HEBP2 gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000051620 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019853 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zylka MJ, Reppert SM (Feb 2000). "Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches". Brain Res Mol Brain Res. 74 (1–2): 175–81. doi:10.1016/S0169-328X(99)00277-6. PMID 10640688.
↑ Szigeti A, Bellyei S, Gasz B, Boronkai A, Hocsak E, Minik O, Bognar Z, Varbiro G, Sumegi B, Gallyas F Jr (Nov 2006). "Induction of necrotic cell death and mitochondrial permeabilization by heme binding protein 2/SOUL". FEBS Lett. 580 (27): 6447–54. doi: 10.1016/j.febslet.2006.10.067 . PMID 17098234. S2CID 19675303.
↑ "Entrez Gene: HEBP2 heme binding protein 2".

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID 14574404.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Liu L, McKeehan WL (2002). "Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity". Genomics. 79 (1): 124–36. doi:10.1006/geno.2001.6679. PMC 3241999 . PMID 11827465.
Bohn H, Winckler W (1991). "Isolation and characterization of five new soluble placental tissue proteins (PP22, PP23, PP24, PP25, PP26)". Arch. Gynecol. Obstet. 248 (3): 111–5. doi:10.1007/BF02390087. PMID 2018407. S2CID 23535410.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000051620 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019853 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10640688-5] Zylka MJ, Reppert SM (Feb 2000). "Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches". Brain Res Mol Brain Res. 74 (1–2): 175–81. doi:10.1016/S0169-328X(99)00277-6. PMID 10640688.

[pmid17098234-6] Szigeti A, Bellyei S, Gasz B, Boronkai A, Hocsak E, Minik O, Bognar Z, Varbiro G, Sumegi B, Gallyas F Jr (Nov 2006). "Induction of necrotic cell death and mitochondrial permeabilization by heme binding protein 2/SOUL". FEBS Lett. 580 (27): 6447–54. doi: 10.1016/j.febslet.2006.10.067 . PMID 17098234. S2CID 19675303.

[entrez-7] "Entrez Gene: HEBP2 heme binding protein 2".

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HEBP2

Related Research Articles

References

Further reading