HGFAC

HGFAC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YBW, 1YC0, 2R0K, 2R0L, 2WUB, 2WUC, 3K2U
Identifiers
Aliases	HGFAC , HGFA, HGF activator
External IDs	OMIM: 604552; MGI: 1859281; HomoloGene: 1170; GeneCards: HGFAC; OMA:HGFAC - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4p16.3 Start 3,441,968 bp [1] End 3,449,486 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 B2 Start 35,198,853 bp [2] End 35,205,805 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver right testis left testis right hemisphere of cerebellum right uterine tube ganglionic eminence testicle right frontal lobe ventricular zone anterior pituitary Top expressed in left lobe of liver crypt of lieberkuhn of small intestine large intestine islet of Langerhans left colon duodenum pyloric antrum fetal liver hematopoietic progenitor cell right kidney jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity serine-type endopeptidase activity hydrolase activity Cellular component extracellular region extracellular space cytosol rough endoplasmic reticulum Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3083 54426 Ensembl ENSG00000109758 ENSMUSG00000029102 UniProt Q04756 Q9R098 RefSeq (mRNA) NM_001297439 NM_001528 NM_019447 RefSeq (protein) NP_001284368 NP_001519 NP_062320 Location (UCSC) Chr 4: 3.44 – 3.45 Mb Chr 5: 35.2 – 35.21 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene. ^{[5] [6] [7]}

The protein encoded by this gene, belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000109758 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029102 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Miyazawa K, Shimomura T, Kitamura A, Kondo J, Morimoto Y, Kitamura N (Jun 1993). "Molecular Cloning and Sequence Analysis of the cDNA for a Human Serine Protease Responsible for Activation of Hepatocyte Growth Factor. Structural similarity of the protease precursor to blood coagulation factor XII". J Biol Chem. 268 (14): 10024–8. doi: 10.1016/S0021-9258(18)82167-6 . PMID   7683665.
6. Shimomura T, Kondo J, Ochiai M, Naka D, Miyazawa K, Morimoto Y, Kitamura N (Dec 1993). "Activation of the zymogen of hepatocyte growth factor activator by thrombin". J Biol Chem. 268 (30): 22927–32. doi: 10.1016/S0021-9258(18)41615-8 . PMID   8226803.
7. "Entrez Gene: HGFAC HGF activator".

Further reading

• Nakamura T (1992). "Structure and function of hepatocyte growth factor". Prog. Growth Factor Res. 3 (1): 67–85. doi:10.1016/0955-2235(91)90014-U. PMID   1838014.
• Shimomura T, Ochiai M, Kondo J, Morimoto Y (1992). "A novel protease obtained from FBS-containing culture supernatant, that processes single chain form hepatocyte growth factor to two chain form in serum-free culture". Cytotechnology. 8 (3): 219–29. doi:10.1007/BF02522039. PMID   1368819. S2CID   24061579.
• Miyazawa K, Shimomura T, Kitamura N (1996). "Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator". J. Biol. Chem. 271 (7): 3615–8. doi: 10.1074/jbc.271.7.3615 . PMID   8631970.
• Shimomura T, Denda K, Kitamura A, et al. (1997). "Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor". J. Biol. Chem. 272 (10): 6370–6. doi: 10.1074/jbc.272.10.6370 . PMID   9045658.
• Kawaguchi T, Qin L, Shimomura T, et al. (1997). "Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor". J. Biol. Chem. 272 (44): 27558–64. doi: 10.1074/jbc.272.44.27558 . PMID   9346890.
• Miyazawa K, Wang Y, Minoshima S, et al. (1999). "Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene--phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator". Eur. J. Biochem. 258 (2): 355–61. doi: 10.1046/j.1432-1327.1998.2580355.x . PMID   9874200.
• Kataoka H, Shimomura T, Kawaguchi T, et al. (2001). "Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment". J. Biol. Chem. 275 (51): 40453–62. doi: 10.1074/jbc.M006412200 . PMID   11013244.
• Kataoka H, Meng JY, Itoh H, et al. (2001). "Localization of hepatocyte growth factor activator inhibitor type 1 in Langhans' cells of human placenta". Histochem. Cell Biol. 114 (6): 469–75. doi:10.1007/s004180000228. PMID   11201608. S2CID   25947109.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi: 10.1074/mcp.M300127-MCP200 . PMID   14718574.
• Tjin EP, Derksen PW, Kataoka H, et al. (2004). "Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator". Blood. 104 (7): 2172–5. doi: 10.1182/blood-2003-12-4386 . PMID   15172968.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Shia S, Stamos J, Kirchhofer D, et al. (2005). "Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B". J. Mol. Biol. 346 (5): 1335–49. doi:10.1016/j.jmb.2004.12.048. PMID   15713485.
• Tjin EP, Groen RW, Vogelzang I, et al. (2006). "Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma". Blood. 107 (2): 760–8. doi: 10.1182/blood-2005-05-1929 . PMID   16189274.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC   1850943 . PMID   16335952.