HIRIP3

HIRIP3
Identifiers
Aliases	HIRIP3 , HIRA interacting protein 3
External IDs	OMIM: 603365 MGI: 2142364 HomoloGene: 18218 GeneCards: HIRIP3
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p11.2 Start 29,992,330 bp [1] End 29,996,074 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F3 Start 126,461,144 bp [2] End 126,464,549 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte ganglionic eminence secondary oocyte gastrocnemius muscle cerebellar hemisphere prefrontal cortex external globus pallidus amygdala putamen left ventricle Top expressed in secondary oocyte hand condyle abdominal wall primitive streak fossa mirror maxillary prominence yolk sac seminiferous tubule More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 8479 233876 Ensembl ENSG00000149929 ENSMUSG00000042606 UniProt Q9BW71 Q8BLH7 RefSeq (mRNA) NM_003609 NM_001197323 NM_172746 RefSeq (protein) NP_001184252 NP_003600 NP_766334 Location (UCSC) Chr 16: 29.99 – 30 Mb Chr 7: 126.46 – 126.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

HIRA-interacting protein 3 is a protein that in humans is encoded by the HIRIP3 gene. ^{[5] [6]}

The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a protein complex. Recently, several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the HIRIP3 gene product binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000149929 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042606 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lorain S, Quivy JP, Monier-Gavelle F, Scamps C, Lecluse Y, Almouzni G, Lipinski M (Sep 1998). "Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA". Mol Cell Biol. 18 (9): 5546–56. doi:10.1128/MCB.18.9.5546. PMC   109139 . PMID   9710638.
6. "Entrez Gene: HIRIP3 HIRA interacting protein 3".

Further reading

• Assrir N, Filhol O, Galisson F, Lipinski M (2007). "HIRIP3 is a nuclear phosphoprotein interacting with and phosphorylated by the serine-threonine kinase CK2". Biol. Chem. 388 (4): 391–8. doi:10.1515/BC.2007.045. PMID   17391060. S2CID   37492665.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID   16083285.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.