HMHA1

ARHGAP45
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3D25, 3FT3
Identifiers
Aliases	ARHGAP45 , HA-1, HLA-HA1, HMHA1, histocompatibility (minor) HA-1, Rho GTPase activating protein 45
External IDs	OMIM: 601155 MGI: 1917969 HomoloGene: 69120 GeneCards: ARHGAP45
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,086,628 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,867,306 bp
RNA expression pattern
	Top expressed in
	blood; ; spleen; ; oocyte; ; secondary oocyte; ; monocyte; ; lymph node; ; thymus; ; appendix; ; bone marrow cells; ; right lung;
	Top expressed in
	thymus; ; blood; ; spleen; ; bone marrow; ; subcutaneous adipose tissue; ; Ankle joint; ; yolk sac; ; right lung; ; left lung; ; white adipose tissue;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; metal ion binding ; GTPase activator activity ;
Cellular component	cytosol ; extracellular region ; secretory granule lumen ; azurophil granule lumen ; cytoplasm ; plasma membrane ; membrane ; ruffle membrane ; cell projection ;
Biological process	positive regulation of GTPase activity ; intracellular signal transduction ; regulation of small GTPase mediated signal transduction ; signal transduction ; neutrophil degranulation ;
	Sources:Amigo / QuickGO
Orthologs
	23526
	70719
	ENSG00000180448
	ENSMUSG00000035697
	Q92619
	Q3TBD2
	NM_001258328 ; NM_001282334 ; NM_001282335 ; NM_012292 ; NM_001321232
	NM_001142701 ; NM_027521 ; NM_001347074
	NP_001245257 ; NP_001269263 ; NP_001269264 ; NP_001308161 ; NP_036424
	NP_001136173 ; NP_001334003 ; NP_081797
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 30, 2022

Minor histocompatibility protein HA-1 is a protein that in humans is encoded by the HMHA1 gene.^[5]^[6]^[7]

Related Research Articles

<span class="mw-page-title-main">Major histocompatibility complex</span> Cell surface proteins, part of the acquired immune system

The major histocompatibility complex (MHC) is a large locus on vertebrate DNA containing a set of closely linked polymorphic genes that code for cell surface proteins essential for the adaptive immune system. These cell surface proteins are called MHC molecules.

The human leukocyte antigen (HLA) system or complex is a complex of genes on chromosome 6 in humans which encode cell-surface proteins responsible for the regulation of the immune system. The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals.

HLA class II histocompatibility antigen, DR alpha chain is a protein that in humans is encoded by the HLA-DRA gene. HLA-DRA encodes the alpha subunit of HLA-DR. Unlike the alpha chains of other Human MHC class II molecules, the alpha subunit is practically invariable. However it can pair with, in any individual, the beta chain from 3 different DR beta loci, DRB1, and two of any DRB3, DRB4, or DRB5 alleles. Thus there is the potential that any given individual can form 4 different HLA-DR isoforms.

Minor histocompatibility antigen are receptors on the cellular surface of donated organs that are known to give an immunological response in some organ transplants. They cause problems of rejection less frequently than those of the major histocompatibility complex (MHC). Minor histocompatibility antigens (MiHAs) are diverse, short segments of proteins and are referred to as peptides. These peptides are normally around 9-12 amino acids in length and are bound to both the major histocompatibility complex (MHC) class I and class II proteins. Peptide sequences can differ among individuals and these differences arise from SNPs in the coding region of genes, gene deletions, frameshift mutations, or insertions. About a third of the characterized MiHAs come from the Y chromosome. The proteins are composed of a single immunogenic HLA allele. Prior to becoming a short peptide sequence, the proteins expressed by these polymorphic or diverse genes need to be digested in the proteasome into shorter peptides. These endogenous or self peptides are then transported into the endoplasmic reticulum with a peptide transporter pump called TAP where they encounter and bind to the MHC class I molecule. This contrasts with MHC class II molecules's antigens which are peptides derived from phagocytosis/endocytosis and molecular degradation of non-self entities' proteins, usually by antigen-presenting cells. MiHA antigens are either ubiquitously expressed in most tissue like skin and intestines or restrictively expressed in the immune cells.

Major histocompatibility complex, class II, DR beta 4, also known as HLA-DRB4, is a human gene.

<span class="mw-page-title-main">HLA-DRB5</span>

HLA class II histocompatibility antigen, DRB5 beta chain is a protein that in humans is encoded by the HLA-DRB5 gene.

<span class="mw-page-title-main">Major histocompatibility complex, class II, DQ alpha 1</span>

Major histocompatibility complex, class II, DQ alpha 1, also known as HLA-DQA1, is a human gene present on short arm of chromosome 6 (6p21.3) and also denotes the genetic locus which contains this gene. The protein encoded by this gene is one of two proteins that are required to form the DQ heterodimer, a cell surface receptor essential to the function of the immune system.

HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene.

HLA class II histocompatibility antigen, DM alpha chain is a protein that in humans is encoded by the HLA-DMA gene.

CD177 antigen is a protein that in humans is encoded by the CD177 gene.

Large proline-rich protein BAT3 is a protein that in humans is encoded by the BAT3 gene.

HLA class II histocompatibility antigen, DO alpha chain is a protein that in humans is encoded by the HLA-DOA gene.

HLA class II histocompatibility antigen, DO beta chain is a protein that in humans is encoded by the HLA-DOB gene.

Minor histocompatibility antigen H13 is a protein that in humans is encoded by the HM13 gene.

Large proline-rich protein BAT2 is a protein that in humans is encoded by the BAT2 gene.

DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene. It is a component of the DNA polymerase delta complex.

ATP-dependent RNA helicase DDX3Y is an enzyme that in humans is encoded by the DDX3Y gene.

HLA class II histocompatibility antigen, DQ(6) alpha chain is a protein that in humans is encoded by the HLA-DQA2 gene. Also known as HLA-DXA or DAAP-381D23.2, it is part of the human leucocyte antigen system.

pumilio RNA binding family member 3 is a protein that in humans is encoded by the PUM3 gene.

Myosin IG, also known as myosin 1G and MYO1G, is a protein that in humans is encoded by the MYO1G gene. MYO1G is a member of class I unconventional myosins. Its expression is highly restricted to hematopoietic tissues and cells. It localises exclusively to the plasma membrane and is dependent on both the motor domain and the tail domain. MYO1G regulates cell elasticity possibly by interaction plasma membrane and cortical actin in Jurkat T-cells.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000180448 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035697 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wilke M, Pool J, den Haan JM, Goulmy E (Jan 1999). "Genomic identification of the minor histocompatibility antigen HA-1 locus by allele-specific PCR". Tissue Antigens. 52 (4): 312–317. doi:10.1111/j.1399-0039.1998.tb03053.x. PMID 9820596.
↑ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–329. doi: 10.1093/dnares/3.5.321 . PMID 9039502.
↑ "Entrez Gene: HMHA1 histocompatibility (minor) HA-1".

van Lochem E, van der Keur M, Mommaas AM, et al. (1997). "Functional expression of minor histocompatibility antigens on human peripheral blood dendritic cells and epidermal Langerhans cells". Transpl. Immunol. 4 (2): 151–157. doi:10.1016/S0966-3274(96)80009-8. hdl: 1887/2991 . PMID 8843592.
Aróstegui JI, Gallardo D, Rodríguez-Luaces M, et al. (2001). "Genomic typing of minor histocompatibility antigen HA-1 by reference strand mediated conformation analysis (RSCA)". Tissue Antigens. 56 (1): 69–76. doi:10.1034/j.1399-0039.2000.560109.x. PMID 10958358.
Kaminski WE, Piehler A, Schmitz G (2001). "Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene". Biochem. Biophys. Res. Commun. 278 (3): 782–789. doi:10.1006/bbrc.2000.3880. PMID 11095984.
Gillespie G, Mutis T, Schrama E, et al. (2002). "HLA class I-minor histocompatibility antigen tetramers select cytotoxic T cells with high avidity to the natural ligand". Hematol. J. 1 (6): 403–10. doi:10.1038/sj/thj/6200065. PMID 11920221.
Fujii N, Hiraki A, Ikeda K, et al. (2002). "Expression of minor histocompatibility antigen, HA-1, in solid tumor cells". Transplantation. 73 (7): 1137–1141. doi:10.1097/00007890-200204150-00022. PMID 11965046. S2CID 21504762.
Mutis T, Blokland E, Kester M, et al. (2002). "Generation of minor histocompatibility antigen HA-1-specific cytotoxic T cells restricted by nonself HLA molecules: a potential strategy to treat relapsed leukemia after HLA-mismatched stem cell transplantation". Blood. 100 (2): 547–552. doi:10.1182/blood-2002-01-0024. PMID 12091347. S2CID 31440495.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Wilke M, Dolstra H, Maas F, et al. (2004). "Quantification of the HA-1 gene product at the RNA level; relevance for immunotherapy of hematological malignancies". Hematol. J. 4 (5): 315–320. doi:10.1038/sj.thj.6200318. PMID 14502255.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID 14702039. S2CID 21903526.
Kotzampasaki EM, Spyropoulou-Vlachou MS, Kalofoutis C, et al. (2005). "Minor histocompatibility antigen HA-1 and HPA-5 polymorphisms in HLA-identical related bone marrow transplantation". Transplant. Proc. 36 (6): 1735–1738. doi:10.1016/j.transproceed.2004.06.007. PMID 15350465.
Mommaas B, Stegehuis-Kamp JA, van Halteren AG, et al. (2005). "Cord blood comprises antigen-experienced T cells specific for maternal minor histocompatibility antigen HA-1". Blood. 105 (4): 1823–1827. doi:10.1182/blood-2004-07-2832. PMID 15498856.
Harangi M, Kaminski WE, Fleck M, et al. (2005). "Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjögren's syndrome". Eur. J. Immunol. 35 (1): 305–317. doi: 10.1002/eji.200425406 . PMID 15593299.
Krishnan NS, Higgins RM, Lam FT, et al. (2007). "HA-1 mismatch has significant effect in chronic allograft nephropathy in clinical renal transplantation". Transplant. Proc. 39 (5): 1439–1445. doi:10.1016/j.transproceed.2007.02.066. PMID 17580157.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000180448 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035697 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9820596-5] Wilke M, Pool J, den Haan JM, Goulmy E (Jan 1999). "Genomic identification of the minor histocompatibility antigen HA-1 locus by allele-specific PCR". Tissue Antigens. 52 (4): 312–317. doi:10.1111/j.1399-0039.1998.tb03053.x. PMID 9820596.

[pmid9039502-6] Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–329. doi: 10.1093/dnares/3.5.321 . PMID 9039502.

[entrez-7] "Entrez Gene: HMHA1 histocompatibility (minor) HA-1".

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HMHA1

Related Research Articles

References

Further reading