HMHA1

ARHGAP45
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3D25, 3FT3
Identifiers
Aliases	ARHGAP45 , HA-1, HLA-HA1, HMHA1, histocompatibility (minor) HA-1, Rho GTPase activating protein 45
External IDs	OMIM: 601155; MGI: 1917969; HomoloGene: 69120; GeneCards: ARHGAP45; OMA:ARHGAP45 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.3 Start 1,065,923 bp [1] End 1,086,628 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 C1 Start 79,852,487 bp [2] End 79,867,306 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood spleen oocyte secondary oocyte monocyte lymph node thymus appendix bone marrow cells Top expressed in granulocyte thymus mesenteric lymph nodes blood spleen tibiofemoral joint bone marrow stroma of bone marrow subcutaneous adipose tissue ankle joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding GTPase activator activity Cellular component cytosol extracellular region secretory granule lumen azurophil granule lumen cytoplasm plasma membrane membrane ruffle membrane cell projection Biological process positive regulation of GTPase activity intracellular signal transduction regulation of small GTPase mediated signal transduction signal transduction neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23526 70719 Ensembl ENSG00000180448 ENSMUSG00000035697 UniProt Q92619 Q3TBD2 RefSeq (mRNA) NM_001258328 NM_001282334 NM_001282335 NM_012292 NM_001321232 NM_001142701 NM_027521 NM_001347074 RefSeq (protein) NP_001245257 NP_001269263 NP_001269264 NP_001308161 NP_036424 NP_001136173 NP_001334003 NP_081797 Location (UCSC) Chr 19: 1.07 – 1.09 Mb Chr 10: 79.85 – 79.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Minor histocompatibility protein HA-1 is a protein that in humans is encoded by the HMHA1 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000180448 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035697 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wilke M, Pool J, den Haan JM, Goulmy E (Jan 1999). "Genomic identification of the minor histocompatibility antigen HA-1 locus by allele-specific PCR". Tissue Antigens. 52 (4): 312–317. doi:10.1111/j.1399-0039.1998.tb03053.x. PMID   9820596.
6. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–329. doi: 10.1093/dnares/3.5.321 . PMID   9039502.
7. "Entrez Gene: HMHA1 histocompatibility (minor) HA-1".

Further reading

• van Lochem E, van der Keur M, Mommaas AM, et al. (1997). "Functional expression of minor histocompatibility antigens on human peripheral blood dendritic cells and epidermal Langerhans cells". Transpl. Immunol. 4 (2): 151–157. doi:10.1016/S0966-3274(96)80009-8. hdl: 1887/2991 . PMID   8843592.
• Aróstegui JI, Gallardo D, Rodríguez-Luaces M, et al. (2001). "Genomic typing of minor histocompatibility antigen HA-1 by reference strand mediated conformation analysis (RSCA)". Tissue Antigens. 56 (1): 69–76. doi:10.1034/j.1399-0039.2000.560109.x. PMID   10958358.
• Kaminski WE, Piehler A, Schmitz G (2001). "Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene". Biochem. Biophys. Res. Commun. 278 (3): 782–789. doi:10.1006/bbrc.2000.3880. PMID   11095984.
• Gillespie G, Mutis T, Schrama E, et al. (2002). "HLA class I-minor histocompatibility antigen tetramers select cytotoxic T cells with high avidity to the natural ligand". Hematol. J. 1 (6): 403–10. doi:10.1038/sj/thj/6200065. PMID   11920221.
• Fujii N, Hiraki A, Ikeda K, et al. (2002). "Expression of minor histocompatibility antigen, HA-1, in solid tumor cells". Transplantation. 73 (7): 1137–1141. doi: 10.1097/00007890-200204150-00022 . PMID   11965046. S2CID   21504762.
• Mutis T, Blokland E, Kester M, et al. (2002). "Generation of minor histocompatibility antigen HA-1-specific cytotoxic T cells restricted by nonself HLA molecules: a potential strategy to treat relapsed leukemia after HLA-mismatched stem cell transplantation". Blood. 100 (2): 547–552. doi: 10.1182/blood-2002-01-0024 . PMID   12091347. S2CID   31440495.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wilke M, Dolstra H, Maas F, et al. (2004). "Quantification of the HA-1 gene product at the RNA level; relevance for immunotherapy of hematological malignancies". Hematol. J. 4 (5): 315–320. doi:10.1038/sj.thj.6200318. PMID   14502255.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039. S2CID   21903526.
• Kotzampasaki EM, Spyropoulou-Vlachou MS, Kalofoutis C, et al. (2005). "Minor histocompatibility antigen HA-1 and HPA-5 polymorphisms in HLA-identical related bone marrow transplantation". Transplant. Proc. 36 (6): 1735–1738. doi:10.1016/j.transproceed.2004.06.007. PMID   15350465.
• Mommaas B, Stegehuis-Kamp JA, van Halteren AG, et al. (2005). "Cord blood comprises antigen-experienced T cells specific for maternal minor histocompatibility antigen HA-1". Blood. 105 (4): 1823–1827. doi: 10.1182/blood-2004-07-2832 . PMID   15498856.
• Harangi M, Kaminski WE, Fleck M, et al. (2005). "Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjögren's syndrome". Eur. J. Immunol. 35 (1): 305–317. doi: 10.1002/eji.200425406 . PMID   15593299.
• Krishnan NS, Higgins RM, Lam FT, et al. (2007). "HA-1 mismatch has significant effect in chronic allograft nephropathy in clinical renal transplantation". Transplant. Proc. 39 (5): 1439–1445. doi:10.1016/j.transproceed.2007.02.066. PMID   17580157.