HMOX2

HMOX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Q32, 2QPP, 2RGZ, 4WMH
Identifiers
Aliases	HMOX2 , HO-2, heme oxygenase 2
External IDs	OMIM: 141251; MGI: 109373; HomoloGene: 1611; GeneCards: HMOX2; OMA:HMOX2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p13.3 Start 4,474,690 bp [1] End 4,510,347 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16 A1|16 2.46 cM Start 4,544,225 bp [2] End 4,584,606 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis prefrontal cortex left ventricle apex of heart superior frontal gyrus Brodmann area 9 right auricle of heart nucleus accumbens body of stomach Top expressed in spermatid seminiferous tubule facial motor nucleus anterior horn of spinal cord dentate gyrus of hippocampal formation granule cell supraoptic nucleus stroma of bone marrow endothelial cell of lymphatic vessel external carotid artery internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity protein binding metal ion binding heme oxygenase (decyclizing) activity heme binding Cellular component intracellular membrane-bounded organelle endoplasmic reticulum membrane membrane endoplasmic reticulum plasma membrane specific granule membrane Biological process response to hypoxia cellular iron ion homeostasis heme oxidation response to oxidative stress heme catabolic process neutrophil degranulation iron ion homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3163 15369 Ensembl ENSG00000277424 ENSG00000103415 ENSMUSG00000004070 UniProt P30519 O70252 RefSeq (mRNA) NM_001127204 NM_001127205 NM_001127206 NM_001286267 NM_001286268 NM_001286269 NM_001286270 NM_001286271 NM_002134 NM_001136066 NM_010443 NM_001357050 NM_001378999 RefSeq (protein) NP_001120676 NP_001120677 NP_001120678 NP_001273196 NP_001273197 NP_001273198 NP_001273199 NP_001273200 NP_002125 NP_001129538 NP_034573 NP_001343979 NP_001365928 Location (UCSC) Chr 16: 4.47 – 4.51 Mb Chr 16: 4.54 – 4.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Heme oxygenase 2 is an enzyme that in humans is encoded by the HMOX2 gene. ^{[5] [6]}

Function

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 (this enzyme) belong to the heme oxygenase family. ^[6]

References

1. ENSG00000103415 GRCh38: Ensembl release 89: ENSG00000277424, ENSG00000103415 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004070 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McCoubrey WK, Ewing JF, Maines MD (Jun 1992). "Human heme oxygenase-2: characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal". Arch Biochem Biophys. 295 (1): 13–20. doi: 10.1016/0003-9861(92)90481-B . PMID   1575508.
6. "Entrez Gene: HMOX2 heme oxygenase (decycling) 2".

Further reading

• Bianchetti CM, Yi L, Ragsdale SW, Phillips GN (2007). "Comparison of Apo- and Heme-bound Crystal Structures of a Truncated Human Heme Oxygenase-2". J Biol Chem. 282 (52): 37624–31. doi: 10.1074/jbc.M707396200 . PMC   2896506 . PMID   17965015.
• Wang J, Zhuang H, Doré S (2006). "Heme oxygenase 2 is neuroprotective against intracerebral hemorrhage". Neurobiol. Dis. 22 (3): 473–6. doi:10.1016/j.nbd.2005.12.009. PMID   16459095. S2CID   43195015.
• Wang J, Doré S (2008). "Heme oxygenase 2 deficiency increases brain swelling and inflammation after intracerebral hemorrhage". Neuroscience. 155 (4): 1133–41. doi:10.1016/j.neuroscience.2008.07.004. PMC   4696610 . PMID   18674596.
• Barañano DE, Snyder SH (2001). "Neural roles for heme oxygenase: Contrasts to nitric oxide synthase". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 10996–1002. Bibcode:2001PNAS...9810996B. doi: 10.1073/pnas.191351298 . PMC   58673 . PMID   11572959.
• Doré S (2002). "Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimer's disease". Free Radic. Biol. Med. 32 (12): 1276–82. doi:10.1016/S0891-5849(02)00805-5. PMID   12057765.
• Kemp PJ (2005). "Hemeoxygenase-2 as an O2 sensor in K+ channel-dependent chemotransduction". Biochem. Biophys. Res. Commun. 338 (1): 648–52. doi:10.1016/j.bbrc.2005.08.110. PMID   16137652.
• Ishikawa K, Takeuchi N, Takahashi S, Matera KM, Sato M, Shibahara S, Rousseau DL, Ikeda-Saito M, Yoshida T (1995). "Heme oxygenase-2. Properties of the heme complex of the purified tryptic fragment of recombinant human heme oxygenase-2". J. Biol. Chem. 270 (11): 6345–50. doi: 10.1074/jbc.270.11.6345 . PMID   7890772.
• Kutty RK, Kutty G, Rodriguez IR, Chader GJ, Wiggert B (1994). "Chromosomal localization of the human heme oxygenase genes: heme oxygenase-1 (HMOX1) maps to chromosome 22q12 and heme oxygenase-2 (HMOX2) maps to chromosome 16p13.3". Genomics. 20 (3): 513–6. doi:10.1006/geno.1994.1213. PMID   8034330.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Takahashi K, Hara E, Suzuki H, Sasano H, Shibahara S (1996). "Expression of heme oxygenase isozyme mRNAs in the human brain and induction of heme oxygenase-1 by nitric oxide donors". J. Neurochem. 67 (2): 482–9. doi:10.1046/j.1471-4159.1996.67020482.x. PMID   8764571. S2CID   12552519.
• Saito-Ohara F, Ikeuchi T, Matsumoto M, Kurata S (1997). "Assignment of the mouse heme oxygenase genes: heme oxygenase-1 (Hmox1) to chromosome 10 band C1 and heme oxygenase-2 (Hmox2) to chromosome 16 band B1". Cytogenet. Cell Genet. 77 (3–4): 180–1. doi:10.1159/000134570. PMID   9284910.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Yoshiki N, Kubota T, Aso T (2000). "Expression and localization of heme oxygenase in human placental villi". Biochem. Biophys. Res. Commun. 276 (3): 1136–42. doi:10.1006/bbrc.2000.3551. PMID   11027601.
• Hanselmann C, Mauch C, Werner S (2001). "Haem oxygenase-1: a novel player in cutaneous wound repair and psoriasis?". Biochem. J. 353 (Pt 3): 459–66. doi:10.1042/0264-6021:3530459. PMC   1221590 . PMID   11171041.
• Appleton SD, Marks GS, Nakatsu K, Brien JF, Smith GN, Graham CH, Lash GE (2003). "Effects of hypoxia on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells". Am. J. Physiol. Heart Circ. Physiol. 284 (3): H853–8. doi:10.1152/ajpheart.00655.2002. PMID   12578814.
• Galey D, Becker K, Haughey N, Kalehua A, Taub D, Woodward J, Mattson MP, Nath A (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes". J. Neurovirol. 9 (3): 358–71. doi:10.1080/13550280390201119. PMID   12775419. S2CID   22016092.
• Zenclussen AC, Lim E, Knoeller S, Knackstedt M, Hertwig K, Hagen E, Klapp BF, Arck PC (2004). "Heme oxygenases in pregnancy II: HO-2 is downregulated in human pathologic pregnancies". Am. J. Reprod. Immunol. 50 (1): 66–76. doi:10.1034/j.1600-0897.2003.00047.x. PMID   14506930. S2CID   35763984.
• Boehning D, Moon C, Sharma S, Hurt KJ, Hester LD, Ronnett GV, Shugar D, Snyder SH (2003). "Carbon monoxide neurotransmission activated by CK2 phosphorylation of heme oxygenase-2". Neuron. 40 (1): 129–37. doi: 10.1016/S0896-6273(03)00596-8 . PMID   14527438. S2CID   11562548.
• Appleton SD, Lash GE, Marks GS, Nakatsu K, Brien JF, Smith GN, Graham CH (2004). "Effect of glucose and oxygen deprivation on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells". Am. J. Physiol. Regul. Integr. Comp. Physiol. 285 (6): R1453–60. doi:10.1152/ajpregu.00234.2003. PMID   14615405.