HNRPH1

HNRNPH1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LXU
Identifiers
Aliases	HNRNPH1 , HNRPH, HNRPH1, hnRNPH, heterogeneous nuclear ribonucleoprotein H1 (H), heterogeneous nuclear ribonucleoprotein H1
External IDs	OMIM: 601035; MGI: 1891925; HomoloGene: 31318; GeneCards: HNRNPH1; OMA:HNRNPH1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	179,634,784 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	50,386,528 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; right uterine tube; ; left ovary; ; right ovary; ; Achilles tendon; ; body of pancreas; ; right lung; ; ganglionic eminence; ; ventricular zone;
	Top expressed in
	tail of embryo; ; superior cervical ganglion; ; hand; ; abdominal wall; ; mandibular prominence; ; maxillary prominence; ; genital tubercle; ; primitive streak; ; Gonadal ridge; ; dermis;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding ; protein binding ; RNA binding ; poly(U) RNA binding ;
Cellular component	catalytic step 2 spliceosome ; spliceosomal complex ; membrane ; nucleoplasm ; cytosol ; nucleus ;
Biological process	mRNA splicing, via spliceosome ; regulation of RNA splicing ; mRNA processing ; RNA processing ; RNA splicing ; fibroblast growth factor receptor signaling pathway ; RNA metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	3187
	59013
	ENSG00000169045
	ENSMUSG00000007850
	P31943
	O35737
	NM_001257293 ; NM_005520 ; NM_001363572
	NM_021510 ; NM_001347487
NP_001244222 ; NP_005511 ; NP_001350501 ; NP_001351154 ; NP_001351155 ;
	NP_001351156 ; NP_001351157 ; NP_001351158 ; NP_001351159 ; NP_001351160 ; NP_001351161 ; NP_001351162 ; NP_001351163 ; NP_001351164 ; NP_001351165 ; NP_001351166 ; NP_001351167 ; NP_001351168 ; NP_001351169 ; NP_001351170 ; NP_001351171 ; NP_001351172 ; NP_001351173 ; NP_001351174 ; NP_001351175 ; NP_001351176 ; NP_001351177 ; NP_001351179 ; NP_001351180 ; NP_001351181 ; NP_001351182 ; NP_001351183 ; NP_001351184
NP_001334416 ; NP_067485 ; NP_001349451 ; NP_001349452 ; NP_001349453 ;
	NP_001349454 ; NP_001349455 ; NP_001349456 ; NP_001349457 ; NP_001349458 ; NP_001349459 ; NP_001349461 ; NP_001349462 ; NP_001349463
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 03, 2024

Heterogeneous nuclear ribonucleoprotein H is a protein ^[5] that in humans is encoded by the HNRNPH1 gene.^[6]^[7]

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. It is very similar to the family member HNRPF. This gene is thought to be potentially involved in hereditary lymphedema type I phenotype.^[7]

Related Research Articles

<span class="mw-page-title-main">Heterogeneous ribonucleoprotein particle</span>

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are complexes of RNA and protein present in the cell nucleus during gene transcription and subsequent post-transcriptional modification of the newly synthesized RNA (pre-mRNA). The presence of the proteins bound to a pre-mRNA molecule serves as a signal that the pre-mRNA is not yet fully processed and therefore not ready for export to the cytoplasm. Since most mature RNA is exported from the nucleus relatively quickly, most RNA-binding protein in the nucleus exist as heterogeneous ribonucleoprotein particles. After splicing has occurred, the proteins remain bound to spliced introns and target them for degradation.

Heterogeneous nuclear ribonucleoprotein A1 is a protein that in humans is encoded by the HNRNPA1 gene. Mutations in hnRNP A1 are causative of amyotrophic lateral sclerosis and the syndrome multisystem proteinopathy.

Heterogeneous nuclear ribonucleoprotein K is a protein that in humans is encoded by the HNRNPK gene. It is found in the cell nucleus that binds to pre-messenger RNA (mRNA) as a component of heterogeneous ribonucleoprotein particles. The simian homolog is known as protein H16. Both proteins bind to single-stranded DNA as well as to RNA and can stimulate the activity of RNA polymerase II, the protein responsible for most gene transcription. The relative affinities of the proteins for DNA and RNA vary with solution conditions and are inversely correlated, so that conditions promoting strong DNA binding result in weak RNA binding.

Heterogeneous nuclear ribonucleoproteins A2/B1 is a protein that in humans is encoded by the HNRNPA2B1 gene.

Heterogeneous nuclear ribonucleoprotein U is a protein that in humans is encoded by the HNRNPU gene.

Poly(rC)-binding protein 1 is a protein that in humans is encoded by the PCBP1 gene.

Poly(rC)-binding protein 2 is a protein that in humans is encoded by the PCBP2 gene.

Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) also known as AU-rich element RNA-binding protein 1 (AUF1) is a protein that in humans is encoded by the HNRNPD gene. Alternative splicing of this gene results in four transcript variants.

Heterogeneous nuclear ribonucleoproteins C1/C2 is a protein that in humans is encoded by the HNRNPC gene.

Scaffold attachment factor B, also known as SAFB, is a gene with homologs that have been studied in humans and mice.

Nucleolar phosphoprotein p130 is a protein that in humans is encoded by the NOLC1 gene.

Heterogeneous nuclear ribonucleoprotein F is a protein that in humans is encoded by the HNRNPF gene.

Heterogeneous nuclear ribonucleoprotein U-like protein 1 is a protein that in humans is encoded by the HNRNPUL1 gene.

Heterogeneous nuclear ribonucleoprotein L is a protein that in humans is encoded by the HNRNPL gene.

Heterogeneous nuclear ribonucleoprotein A/B, also known as HNRNPAB, is a protein which in humans is encoded by the HNRNPAB gene. Although this gene is named HNRNPAB in reference to its first cloning as an RNA binding protein with similarity to HNRNP A and HNRNP B, it is not a member of the HNRNP A/B subfamily of HNRNPs, but groups together closely with HNRNPD/AUF1 and HNRNPDL.

Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.

Heterogeneous nuclear ribonucleoprotein H3 is a protein that in humans is encoded by the HNRNPH3 gene.

Heterogeneous nuclear ribonucleoprotein H2 is a protein that in humans is encoded by the HNRNPH2 gene.

Heterogeneous nuclear ribonucleoprotein D-like, also known as HNRPDL, is a protein which in humans is encoded by the HNRPDL gene.

Polypyrimidine tract-binding protein 1 is a protein that in humans is encoded by the PTBP1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000169045 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000007850 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Penumutchu S, Chiu LY, Meagher JL, Hansen AL, Stuckey JA, Tolbert BS (2018-08-18). "Differential Conformational Dynamics Encoded by the Inter-qRRM linker of hnRNP H". Journal of the American Chemical Society. 140 (37): 11661–11673. doi:10.1021/jacs.8b05366. ISSN 0002-7863. PMC 6648666 . PMID 30122033.
↑ Honore B, Rasmussen HH, Vorum H, Dejgaard K, Liu X, Gromov P, Madsen P, Gesser B, Tommerup N, Celis JE (Jan 1996). "Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes". J Biol Chem. 270 (48): 28780–9. doi: 10.1074/jbc.270.48.28780 . PMID 7499401.
1 2 "Entrez Gene: HNRPH1 heterogeneous nuclear ribonucleoprotein H1 (H)".

Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Matunis MJ, Xing J, Dreyfuss G (1994). "The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization". Nucleic Acids Res. 22 (6): 1059–67. doi:10.1093/nar/22.6.1059. PMC 307930 . PMID 7512260.
Gamberi C, Izaurralde E, Beisel C, Mattaj IW (1997). "Interaction between the human nuclear cap-binding protein complex and hnRNP F." Mol. Cell. Biol. 17 (5): 2587–97. doi:10.1128/MCB.17.5.2587. PMC 232108 . PMID 9111328.
Chou MY, Rooke N, Turck CW, Black DL (1999). "hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells". Mol. Cell. Biol. 19 (1): 69–77. doi:10.1128/MCB.19.1.69. PMC 83866 . PMID 9858532.
Evans AL, Brice G, Sotirova V, et al. (1999). "Mapping of primary congenital lymphedema to the 5q35.3 region". Am. J. Hum. Genet. 64 (2): 547–55. doi:10.1086/302248. PMC 1377764 . PMID 9973292.
Honoré B, Vorum H, Baandrup U (1999). "hnRNPs H, H' and F behave differently with respect to posttranslational cleavage and subcellular localization". FEBS Lett. 456 (2): 274–80. doi: 10.1016/S0014-5793(99)00911-4 . PMID 10456323. S2CID 7617501.
Markovtsov V, Nikolic JM, Goldman JA, et al. (2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300 . PMID 11003644.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID 11790298. S2CID 14132033.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266 . PMID 11991638.
Angenstein F, Evans AM, Settlage RE, et al. (2002). "A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons". J. Neurosci. 22 (20): 8827–37. doi:10.1523/JNEUROSCI.22-20-08827.2002. PMC 6757688 . PMID 12388589.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616 . PMID 14559993.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Honoré B, Baandrup U, Vorum H (2004). "Heterogeneous nuclear ribonucleoproteins F and H/H' show differential expression in normal and selected cancer tissues". Exp. Cell Res. 294 (1): 199–209. doi:10.1016/j.yexcr.2003.11.011. PMID 14980514.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. CiteSeerX 10.1.1.323.5263 . doi: 10.1016/j.cub.2004.07.051 . PMID 15324660. S2CID 2371325.
Lin KT, Lu RM, Tarn WY (2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo". Mol. Cell. Biol. 24 (20): 9176–85. doi:10.1128/MCB.24.20.9176-9185.2004. PMC 517884 . PMID 15456888.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000169045 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000007850 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Penumutchu S, Chiu LY, Meagher JL, Hansen AL, Stuckey JA, Tolbert BS (2018-08-18). "Differential Conformational Dynamics Encoded by the Inter-qRRM linker of hnRNP H". Journal of the American Chemical Society. 140 (37): 11661–11673. doi:10.1021/jacs.8b05366. ISSN 0002-7863. PMC 6648666 . PMID 30122033.

[pmid7499401-6] Honore B, Rasmussen HH, Vorum H, Dejgaard K, Liu X, Gromov P, Madsen P, Gesser B, Tommerup N, Celis JE (Jan 1996). "Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes". J Biol Chem. 270 (48): 28780–9. doi: 10.1074/jbc.270.48.28780 . PMID 7499401.

[entrez-7] 1 2 "Entrez Gene: HNRPH1 heterogeneous nuclear ribonucleoprotein H1 (H)".

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HNRPH1

Related Research Articles

References

Further reading